Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 403 Research Program Area: General Canine Health |
Application of the 7.5X Canine Genome Assembly to Generate a 1Mb Cytogenetic BAC-Map of the Canine Genome Thomas, R., Duke, S. E., Karlsson, E. K., Evans, A., Ellis, P., Lindblad-Toh, K., … Breen, M. (2008). A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis. Cytogenetic and Genome Research, 122(2), 110–121. https://doi.org/10.1159/000163088
Thomas, Rachael, Duke, S. E., Bloom, S. K., Breen, T. E., Young, A. C., Feiste, E., … Breen, M. (2007). A Cytogenetically Characterized, Genome-Anchored 10-Mb BAC Set and CGH Array for the Domestic Dog. Journal of Heredity, 98(5), 474–484. https://doi.org/10.1093/jhered/esm053
Thomas, Rachael, Duke, S. E., Wang, H. J., Breen, T. E., Higgins, R. J., Linder, K. E., … Breen, M. (2009). ‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors. Journal of Neuro-Oncology, 94(3), 333–349. https://doi.org/10.1007/s11060-009-9877-5 |
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Grant Number: 00795-A Research Program Area: Musculoskeletal Conditions and Disease |
Efficacy of Coxofemoral Denervation for the Treatment of Chronic Hip Dysplasia and Pain in Dogs: An Objective Analysis Using Ground Reaction Forces Lister, S. A., Roush, J. K., Renberg, W. C., & Stephens, C. L. (2009). Ground reaction force analysis of unilateral coxofemoral denervation for the treatment of canine hip dysplasia. Veterinary and Comparative Orthopaedics and Traumatology, 22(02), 137–141. https://doi.org/10.3415/VCOT-08-02-0024 |
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Grant Number: 01212-A Research Program Area: Neurology |
Phenotypic Characterization of Peripheral Nerve Disease in Degenerative Myelopathy Dogs Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106 |
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Grant Number: 1946 Research Program Area: Kidney & Urological Disease |
Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests Bannasch, D., & Henthorn, P. S. (2009). Changing Paradigms in Diagnosis of Inherited Defects Associated with Urolithiasis. Veterinary Clinics of North America: Small Animal Practice, 39(1), 111–125. https://doi.org/10.1016/j.cvsm.2008.09.006
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Grant Number: 248 Research Program Area: Kidney & Urological Disease |
Use of an Artificial Urethral Sphincter in Dogs with Urethral Sphincter Mechanism Incompetence Rose, S. A., Adin, C. A., Ellison, G. W., Sereda, C. W., & Archer, L. L. (2009). Long-Term Efficacy of a Percutaneously Adjustable Hydraulic Urethral Sphincter for Treatment of Urinary Incontinence in Four Dogs. Veterinary Surgery, 38(6), 747–753. https://doi.org/10.1111/j.1532-950X.2009.00560.x |
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Grant Number: 00700-A Research Program Area: Cardiology |
Widescale Genome Profiling in Great Danes with Dilated Cardiomyopathy Oyama, M. A., Chittur, S. V., & Reynolds, C. A. (2009). Decreased Triadin and Increased Calstabin2 Expression in Great Danes with Dilated Cardiomyopathy. Journal of Veterinary Internal Medicine, 23(5), 1014–1019. https://doi.org/10.1111/j.1939-1676.2009.0360.x |
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Grant Number: 00570-A Research Program Area: General Canine Health |
Capping Chromosome Ends with de Novo Genetic Markers to Ensure Closure of the Canine Linkage Map Wong, A. K., & Neff, M. W. (2009). DOGSET?: pre-designed primer sets for fine-scale mapping and DNA sequence interrogation in the dog. Animal Genetics, 40(4), 569–571. https://doi.org/10.1111/j.1365-2052.2009.01875.x |
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Grant Number: 2303 Research Program Area: Cardiology |
Molecular Analysis of Familial Ventricular Arrhythmias in the Boxer Dog Scansen, B. A., Meurs, K. M., Spier, A. W., Koplitz, S., & Baumwart, R. D. (2009). Temporal Variability of Ventricular Arrhythmias in Boxer Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy. Journal of Veterinary Internal Medicine, 23(5), 1020–1024. https://doi.org/10.1111/j.1939-1676.2009.0366.x
Spier, A. W., & Meurs, K. M. (2004). Assessment of heart rate variability in Boxers with arrhythmogenic right ventricular cardiomyopathy. Journal of the American Veterinary Medical Association, 224(4), 534–537. https://doi.org/10.2460/javma.2004.224.534
Stern, J. A., Meurs, K. M., Spier, A. W., Koplitz, S. L., & Baumwart, R. D. (2010). Ambulatory electrocardiographic evaluation of clinically normal adult Boxers. Journal of the American Veterinary Medical Association, 236(4), 430–433. https://doi.org/10.2460/javma.236.4.430 |
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Grant Number: 247 Research Program Area: Musculoskeletal Conditions and Disease |
The Study of the Genetics of Cranial Cruciate Ligament Disease in the Dog Wilke, V. L., Conzemius, M. C., & Rothschild, M. F. (2005). SNP detection and association analyses of candidate genes for rupture of the cranial cruciate ligament in the dog: Brief note. Animal Genetics, 36(6), 519–521. https://doi.org/10.1111/j.1365-2052.2005.01355.x
Wilke, Vicki L., Conzemius, M. G., Kinghorn, B. P., Macrossan, P. E., Cai, W., & Rothschild, M. F. (2006). Inheritance of rupture of the cranial cruciate ligament in Newfoundlands. Journal of the American Veterinary Medical Association, 228(1), 61–64. https://doi.org/10.2460/javma.228.1.61
Wilke, Vicki L., Zhang, S., Evans, R. B., Conzemius, M. G., & Rothschild, M. F. (2009). Identification of chromosomal regions associated with cranial cruciate ligament rupture in a population of Newfoundlands. American Journal of Veterinary Research, 70(8), 1013–1017. https://doi.org/10.2460/ajvr.70.8.1013
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Grant Number: 00812-A Research Program Area: Dermatology and Allergic Disease |
Investigation of the Canine Cathepsin L Gene (CTSL) as a Candidate for Alopecia X in Keeshonden and Pomeranians Mausberg, E.-M., Drögemüller, C., Dolf, G., Leeb, T., Rüfenacht, S., & Welle, M. (2007). Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden. Animal Biotechnology, 18(4), 291–296. https://doi.org/10.1080/10495390701547461
Mausberg, E.-M., Drogemuller, C., Dolf, G., Rufenacht, S., Welle, M., & Leeb, T. (2008). Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden. Veterinary Record, 163(4), 121–123. https://doi.org/10.1136/vr.163.4.121
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Grant Number: 00803-A Research Program Area: Gastrointestinal Disease |
Toll-Like Receptors in Dogs And Their Role in Intestinal Inflammation Burgener, I. A., König, A., Allenspach, K., Sauter, S. N., Boisclair, J., Doherr, M. G., & Jungi, T. W. (2008). Upregulation of Toll-Like Receptors in Chronic Enteropathies in Dogs. Journal of Veterinary Internal Medicine, 22(3), 553–560. https://doi.org/10.1111/j.1939-1676.2008.0093.x |
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Grant Number: 00457-A Research Program Area: Immunology and Infectious Disease |
Canine Idiopathic Rhinitis is Associated with Bartonellosis Hawkins, E. C., Johnson, L. R., Guptill, L., Marr, H. S., Breitschwerdt, E. B., & Birkenheuer, A. J. (2008). Failure to identify an association between serologic or molecular evidence of Bartonella infection and idiopathic rhinitis in dogs. Journal of the American Veterinary Medical Association, 233(4), 597-599. https://doi.org/10.2460/javma.233.4.597 |
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Grant Number: 2227 Research Program Area: Ophthalmology |
Defining the Mode of Inheritance for Primary Lens Luxation and Juvenile Cataracts in the Jack Russell Terrier Oberbauer, A. M., Hollingsworth, S. R., Belanger, J. M., Regan, K. R., & Famula, T. R. (2008). Inheritance of cataracts and primary lens luxation in Jack Russell Terriers. American Journal of Veterinary Research, 69(2), 222–227. https://doi.org/10.2460/ajvr.69.2.222 |
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Grant Number: 960 Research Program Area: Hepatic Disease |
Identification of Genes That Cause Liver Copper Toxicosis Coronado, V. A., Bonneville, J. A., Nazer, H., Roberts, E. A., & Cox, D. W. (2005). COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology. Clinical Genetics, 68(6), 548–551. https://doi.org/10.1111/j.1399-0004.2005.00524.x
Coronado, Veronica A., Damaraju, D., Kohijoki, R., & Cox, D. W. (2003). New haplotypes in the Bedlington terrier indicate complexity in copper toxicosis. Mammalian Genome: Official Journal of the International Mammalian Genome Society, 14(7), 483–491. https://doi.org/10.1007/s00335-002-2255-3
Coronado, Veronica A., O’Neill, B., Nanji, M., & Cox, D. W. (2008). Polymorphisms in canine ATP7B: Candidate modifier of copper toxicosis in the Bedlington Terrier. The Veterinary Journal, 177(2), 293–296. https://doi.org/10.1016/j.tvjl.2007.04.012 |
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Grant Number: 00754B Research Program Area: Oncology |
Mapping of the Gene for Transitional Cell Carcinoma in the Scottish Terrier and West Highland White Terrier Cadieu, E., & Ostrander, E. A. (2007). Canine Genetics Offers New Mechanisms for the Study of Human Cancer. Cancer Epidemiology Biomarkers & Prevention, 16(11), 2181–2183. https://doi.org/10.1158/1055-9965.EPI-07-2667
Dhawan, D., Ramos-Vara, J. A., Stewart, J. C., Zheng, R., & Knapp, D. W. (2009). Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer. Urologic Oncology: Seminars and Original Investigations, 27(3), 284–292. https://doi.org/10.1016/j.urolonc.2008.02.015
Fleischer, S., Sharkey, M., Mealey, K., Ostrander, E. A., & Martinez, M. (2008). Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model. The AAPS Journal, 10(1), 110–119. https://doi.org/10.1208/s12248-008-9011-1
Quignon, P., Herbin, L., Cadieu, E., Kirkness, E. F., Hédan, B., Mosher, D. S., … Hitte, C. (2007). Canine Population Structure: Assessment and Impact of Intra-Breed Stratification on SNP-Based Association Studies. PLoS ONE, 2(12), e1324. https://doi.org/10.1371/journal.pone.0001324
Wayne, R. K., & Ostrander, E. A. (2007). Lessons learned from the dog genome. Trends in Genetics, 23(11), 557–567. https://doi.org/10.1016/j.tig.2007.08.013 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
