00700-A: Widescale Genome Profiling in Great Danes with Dilated Cardiomyopathy

Grant Status: Closed

Grant Amount: $12,960
Mark A. Oyama, DVM; University of Pennsylvania
April 1, 2006 - March 31, 2007


Breed(s): Great Dane
Research Program Area: Cardiology
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A previous study involving widescale genomic profiling in dogs with heart disease has provided a large amount of useful data regarding the pathophysiology and potential etiology of disease. We propose performing oligonucleotide microarray analysis of over 25,000 genes in Great Danes with advanced dilated cardiomyopathy. Microarray studies evaluate of a large proportion of the total canine genome and produce a molecular portrait of the disease process. The proposed study will reveal the transcriptional activity of genes suspected to be involved in the development of DCM, as well as identify new candidate genes that merit further study.


Oyama, M. A., Chittur, S. V., & Reynolds, C. A. (2009). Decreased Triadin and Increased Calstabin2 Expression in Great Danes with Dilated Cardiomyopathy. Journal of Veterinary Internal Medicine, 23(5), 1014–1019. https://doi.org/10.1111/j.1939-1676.2009.0360.x

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