Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01410A Research Program Area: Oncology |
Positional Cloning of Histiocytic Sarcoma (HS) in the Bernese Mountain Dog (BMD) and Flat Coated Retriever (Part A - See also 01410B) Abadie, J., Hedan, B., Cadieu, E., De Brito, C., Devauchelle, P., Bourgain, C., … Andre, C. (2009). Epidemiology, Pathology, and Genetics of Histiocytic Sarcoma in the Bernese Mountain Dog Breed. Journal of Heredity, 100(Supplement 1), S19–S27. https://doi.org/10.1093/jhered/esp039
Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-201
Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Ostrander, E. A. (2012). The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer. Cancer Epidemiology Biomarkers & Prevention, 21(7), 1019–1027. https://doi.org/10.1158/1055-9965.EPI-12-0190-T |
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Grant Number: 01502-A Research Program Area: Oncology |
Myxoma Virus Oncolytic Therapy in Mouse Models of Canine Cancer Gentschev, I., Adelfinger, M., Josupeit, R., Rudolph, S., Ehrig, K., Donat, U., … Szalay, A. A. (2012). Preclinical Evaluation of Oncolytic Vaccinia Virus for Therapy of Canine Soft Tissue Sarcoma. PLoS ONE, 7(5), e37239. https://doi.org/10.1371/journal.pone.0037239 |
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Grant Number: 00866-A Research Program Area: Ophthalmology |
Phenotypic Characterization Using Electroretinography in Hereditary Retinal Degeneration of English Springer Spaniels Narfström, K., Jeong, M., Hyman, J., Madsen, R. W., & Bergström, T. F. (2012). Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation. Stem Cells International, 2012, 1–12. https://doi.org/10.1155/2012/685901 |
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Grant Number: 01336B Research Program Area: Oncology |
Finding the Mutations that Increase Susceptibility to Transitional Cell Carcinoma in the Scottish Terrier, West Highland Terrier, and Shetland Sheepdog Hahn, N. M., Bonney, P. L., Dhawan, D., Jones, D. R., Balch, C., Guo, Z., … Knapp, D. W. (2012). Subcutaneous 5-Azacitidine Treatment of Naturally Occurring Canine Urothelial Carcinoma: A Novel Epigenetic Approach to Human Urothelial Carcinoma Drug Development. Journal of Urology, 187(1), 302–309. https://doi.org/10.1016/j.juro.2011.09.010
Mellersh, C. S., Hitte, C., Richman, M., Vignaux, F., Priat, C., Jouquand, S., … Galibert, F. (2000). An integrated linkage-radiation hybrid map of the canine genome. Mammalian Genome, 11(2), 120–130. https://doi.org/10.1007/s003350010024
Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010). Man’s Best Friend Becomes Biology’s Best in Show: Genome Analyses in the Domestic Dog. Annual Review of Genetics, 44(1), 309–336. https://doi.org/10.1146/annurev-genet-102808-115200 |
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Grant Number: 01031-A Research Program Area: Immunology and Infectious Disease |
Determination of Target Antigens in Canine Primary Immune-Mediated Hemolytic Anemia Tan, E., Bienzle, D., Shewen, P., Kruth, S., & Wood, D. (2012). Potentially antigenic RBC membrane proteins in dogs with primary immune-mediated hemolytic anemia. Veterinary Clinical Pathology, n/a-n/a. https://doi.org/10.1111/j.1939-165X.2011.00391.x
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Grant Number: 01384-A Research Program Area: Oncology |
Improved Imaging to Monitor Therapy Response of Urinary Bladder Cancer Using 3D Volume Ultrasonography Naughton, J. F., Widmer, W. R., Constable, P. D., & Knapp, D. W. (2012). Accuracy of three-dimensional and two-dimensional ultrasonography for measurement of tumor volume in dogs with transitional cell carcinoma of the urinary bladder. American Journal of Veterinary Research, 73(12), 1919–1924. https://doi.org/10.2460/ajvr.73.12.1919 |
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Grant Number: 1312 Research Program Area: Musculoskeletal Conditions and Disease |
Association mapping study of Legg-Calve-Perthes Disease in the West Highland White Terrier, Yorkshire Terrier, and Cairn Terriers Starr-Moss, A. N., Nowend, K. L., Alling, K. M., Zepp, E. J., & Murphy, K. E. (2012). Exclusion of COL2A1 in canine Legg-Calve´- Perthes disease. Animal Genetics, 43(1), 112. https://doi.org/10.1111/j.1365-2052.2011.02215.x
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Grant Number: 0002214T Research Program Area: Oncology |
Identification of a 5-10Mb BAC Set as a Cytogenetic Resource and for the Development of an Ordered CGH Microarray for Cancer Studies in the Dog Breen, M., Hitte, C., Lorentzen, T. D., Thomas, R., Cadieu, E., Sabacan, L., … Ostrander, E. A. (2004). An integrated 4249 marker FISH/RH map of the canine genome. BMC Genomics, 5(65), 11.
Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467
Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613
Rebbeck, C. A., Thomas, R., Breen, M., Leroi, A. M., & Burt, A. (2009). ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER. Evolution, 63(9), 2340–2349. https://doi.org/10.1111/j.1558-5646.2009.00724.x
Thomas, R. (2005). Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Research, 15(12), 1831–1837. https://doi.org/10.1101/gr.3825705
Thomas, R., Bridge, W., Benke, K., & Breen, M. (2003). Isolation and chromosomal assignment of canine genomic BAC clones representing 25 cancer-related genes. Cytogenetic and Genome Research, 102(1–4), 249–253. https://doi.org/10.1159/000075757
Thomas, R., Fiegler, H., Ostrander, E. A., Galibert, F., Carter, N. P., & Breen, M. (2003). A canine cancer-gene microarray for CGH analysis of tumors. Cytogenetic and Genome Research, 102(1–4), 254–260. https://doi.org/10.1159/000075758
Thomas, R, Smith, K. C., Ostrander, E. A., Galibert, F., & Breen, M. (2003). Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes. British Journal of Cancer, 89(8), 1530–1537. https://doi.org/10.1038/sj.bjc.6601275
Thomas, Rachael, Duke, S. E., Bloom, S. K., Breen, T. E., Young, A. C., Feiste, E., … Breen, M. (2007). A Cytogenetically Characterized, Genome-Anchored 10-Mb BAC Set and CGH Array for the Domestic Dog. Journal of Heredity, 98(5), 474–484. https://doi.org/10.1093/jhered/esm053
Thomas, Rachael, Rebbeck, C., Leroi, A. M., Burt, A., & Breen, M. (2009). Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis. Chromosome Research, 17(7), 927–934. https://doi.org/10.1007/s10577-009-9080-8
Tsai, P.-C., & Breen, M. (2012). Array-based comparative genomic hybridization–guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs. American Journal of Veterinary Research, 73(9), 1335–1343. https://doi.org/10.2460/ajvr.73.9.1335 |
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Grant Number: 01152 Research Program Area: Oncology |
Liposomal Bisphosphonate Therapy for Malignant Histiocytosis
Hafeman, S. D., Varland, D., & Dow, S. W. (2012). Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Veterinary and Comparative Oncology, 10(1), 44–56. https://doi.org/10.1111/j.1476-5829.2011.00274.x |
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Grant Number: 01366-A Research Program Area: Cardiology |
Multifaceted investigation into the characteristics of degenerative mitral valve disease in Norfolk Terriers: nutritional and environmental characteristics - Part 2 Trafny, D. J., Freeman, L. M., Bulmer, B. J., MacGregor, J. M., Rush, J. E., Meurs, K. M., & Oyama, M. A. (2012). Auscultatory, echocardiographic, biochemical, nutritional, and environmental characteristics of mitral valve disease in Norfolk Terriers. Journal of Veterinary Cardiology, 14(1), 261–267. https://doi.org/10.1016/j.jvc.2011.10.002 |
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Grant Number: 01180-A Research Program Area: Neurology |
The Prognostic Value of Various Cerebrospinal Fluid Biomarkers in Dogs with Acute Thoracolumbar Disk Herniation Jeffery, N. D., Levine, J. M., Olby, N. J., & Stein, V. M. (2013). Intervertebral Disk Degeneration in Dogs: Consequences, Diagnosis, Treatment, and Future Directions. Journal of Veterinary Internal Medicine, 27(6), 1318–1333. https://doi.org/10.1111/jvim.12183
Levine, G. J., Levine, J. M., Witsberger, T. H., Kerwin, S. C., Russell, K. E., Suchodolski, J., … Fosgate, G. T. (2010). Cerebrospinal Fluid Myelin Basic Protein as a Prognostic Biomarker in Dogs with Thoracolumbar Intervertebral Disk Herniation. Journal of Veterinary Internal Medicine, 24(4), 890–896. https://doi.org/10.1111/j.1939-1676.2010.0531.x
Witsberger, T. H., Levine, J. M., Fosgate, G. T., Slater, M. R., Kerwin, S. C., Russell, K. E., & Levine, G. J. (2012). Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation. Journal of the American Veterinary Medical Association, 240(5), 555–562. https://doi.org/10.2460/javma.240.5.555
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Grant Number: 01271B Research Program Area: Neurology |
Mapping of Additional Genes Associated with Canine Degenerative Myelopathy Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106
Coates, J. R., & Wininger, F. A. (2010). Canine Degenerative Myelopathy. Veterinary Clinics of North America: Small Animal Practice, 40(5), 929–950. https://doi.org/10.1016/j.cvsm.2010.05.001
Shelton, G. D., Johnson, G. C., O’Brien, D. P., Katz, M. L., Pesayco, J. P., Chang, B. J., … Coates, J. R. (2012). Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and Boxers. Journal of the Neurological Sciences, 318(1–2), 55–64. https://doi.org/10.1016/j.jns.2012.04.003
Wininger, F. A., Zeng, R., Johnson, G. S., Katz, M. L., Johnson, G. C., Bush, W. W., … Coates, J. R. (2011). Degenerative Myelopathy in a Bernese Mountain Dog with a Novel SOD1 Missense Mutation. Journal of Veterinary Internal Medicine, 25(5), 1166–1170. https://doi.org/10.1111/j.1939-1676.2011.0760.x |
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Grant Number: 01142 Research Program Area: Cardiology |
Cutting Balloon Valvuloplasty for Dogs with Subaortic Stenosis Kleman, M. E., Estrada, A. H., Maisenbacher, H. W., Prošek, R., Pogue, B., Shih, A., & Paolillo, J. A. (2012). How to perform combined cutting balloon and high pressure balloon valvuloplasty for dogs with subaortic stenosis. Journal of Veterinary Cardiology, 14(2), 351–361. https://doi.org/10.1016/j.jvc.2011.11.008 |
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Grant Number: 00336B Research Program Area: Oncology |
Mapping of the Gene for Malignant Histiocytosis in the Bernese Mountain Dog Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-201
Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Ostrander, E. A. (2012). The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer. Cancer Epidemiology Biomarkers & Prevention, 21(7), 1019–1027. https://doi.org/10.1158/1055-9965.EPI-12-0190-T |
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Grant Number: 01226-A Research Program Area: Oncology - Lymphoma |
Evaluation of Multidrug Resistance Genes in Primary Canine Lymphoma Cells Exposed to Enrofloxacin and Prednisolone
Boudreaux, B. B., Smith, A. N., Lee, H. P., Boothe, D. M., Higginbotham, M. L., Whitley, E. M., … Behrend, E. N. (2012). In vitro Evaluation of ABCB1 After Exposure to Prednisolone and Enrofloxacin in Two Canine Lymphoid Cell Lines: A Pilot Study. International Journal of Applied Research in Veterinary Medicine, 10(1), 11. |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
