Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 225 Research Program Area: Endocrinology |
Establishing a Genetic Linkage Between Addison's Disease and DNA Markers Famula, T. R., Belanger, J. M., & Oberbauer, A. M. (2003). Heritability and complex segregation analysis of hypoadrenocorticism in the Standard Poodle. Journal of Small Animal Practice, 44(1), 8–12. https://doi.org/10.1111/j.1748-5827.2003.tb00096.x
Oberbauer, A., Bell, J., Belanger, J., & Famula, T. (2006). Genetic evaluation of Addison’s disease in the Portuguese Water Dog. BMC Veterinary Research, 2(15), 7. https://doi.org/doi:10.1186/1746-6148-2-15
Rincon, G., Tengvall, K., Belanger, J. M., Lagoutte, L., Medrano, J. F., André, C., … Oberbauer, A. M. (2011). Comparison of buccal and blood-derived canine DNA, either native or whole genome amplified, for array-based genome-wide association studies. BMC Research Notes, 4(1), 226. https://doi.org/10.1186/1756-0500-4-226
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Grant Number: 01231-A Research Program Area: Immunology and Infectious Disease |
Prevalence and Localization of Bartonella spp. in Vascular Tumors from Dogs
Varanat, M., Maggi, R. G., Linder, K. E., & Breitschwerdt, E. B. (2011). Molecular prevalence of Bartonella, Babesia, and Hemotropic Mycoplasma sp. in dogs with splenic disease. Journal of Veterinary Internal Medicine, 25(6), 1284–1291. https://doi.org/10.1111/j.1939-1676.2011.00811.x |
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Grant Number: 00615B Research Program Area: Oncology - Lymphoma |
Heritable and Sporadic Genetic Lesions in Canine Lymphoma Thomas, R., Seiser, E. L., Motsinger-Reif, A., Borst, L., Valli, V. E., Kelley, K., … Breen, M. (2011). Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leukemia & Lymphoma, 52(7), 1321–1335. https://doi.org/10.3109/10428194.2011.559802 |
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Grant Number: 598 Research Program Area: Epilepsy Initiative |
Candidate Gene Markers for Epilepsy in Beagles and Other Breeds Ekenstedt, K. J., Patterson, E. E., Minor, K. M., & Mickelson, J. R. (2011). Candidate genes for idiopathic epilepsy in four dog breeds. BMC Genetics, 12(1), 38. https://doi.org/10.1186/1471-2156-12-38 |
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Grant Number: 732 Research Program Area: Neurology |
Identification of Mutations Responsible for Hereditary Neurodegenerative Disorders in Dogs Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106
Chen, X., Johnson, G. S., Schnabel, R. D., Taylor, J. F., Johnson, G. C., Parker, H. G., … O’Brien, D. P. (2008). A neonatal encephalopathy with seizures in Standard Poodle Dogs with a missense mutation in the canine ortholog of ATF2. Neurogenetics, 9(1), 41–49. https://doi.org/10.1007/s10048-007-0112-2
Farias, F. H. G., Zeng, R., Johnson, G. S., Wininger, F. A., Taylor, J. F., Schnabel, R. D., … Katz, M. L. (2011). A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan Terriers. Neurobiology of Disease, 42(3), 468–474. https://doi.org/10.1016/j.nbd.2011.02.009
Katz, M. L., Coates, J. R., Cooper, J. J., O’Brien, D. P., Jeong, M., & Narfström, K. (2008). Retinal Pathology in a Canine Model of Late Infantile Neuronal Ceroid Lipofuscinosis. Investigative Ophthalmology & Visual Science, 49(6), 2686. https://doi.org/10.1167/iovs.08-1712
Katz, M. L., Farias, F. H., Sanders, D. N., Zeng, R., Khan, S., Johnson, G. S., & O’Brien, D. P. (2011). A Missense Mutation in Canine CLN6 in an Australian Shepherd with Neuronal Ceroid Lipofuscinosis. Journal of Biomedicine and Biotechnology, 2011, 1–6. https://doi.org/10.1155/2011/198042
O’Brien, D. P., & Katz, M. L. (2008). Neuronal Ceroid Lipofuscinosis in 3 Australian Shepherd Littermates. Journal of Veterinary Internal Medicine, 22(2), 472–475. https://doi.org/10.1111/j.1939-1676.2008.0079.x
Sanders, D. N., Farias, F. H., Johnson, G. S., Chiang, V., Cook, J. R., O’Brien, D. P., … Katz, M. L. (2010). A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund. Molecular Genetics and Metabolism, 100(4), 349–356. https://doi.org/10.1016/j.ymgme.2010.04.009 |
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Grant Number: 01093A Research Program Area: Oncology |
Positional Cloning of the Gene(s) for Gastric Cancer in the Chow Chow Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010). Man’s Best Friend Becomes Biology’s Best in Show: Genome Analyses in the Domestic Dog. Annual Review of Genetics, 44(1), 309–336. https://doi.org/10.1146/annurev-genet-102808-115200
Shearin, A. L., & Ostrander, E. A. (2010). Leading the way: canine models of genomics and disease. Disease Models & Mechanisms, 3(1–2), 27–34. https://doi.org/10.1242/dmm.004358
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Grant Number: 01066-A Research Program Area: Musculoskeletal Conditions and Disease |
Predictive Serum Biomarkers for Canine Endurance Exercise Love, S. B., Davis, M. S., Goad, C., Murphy, K., Aichele, D. B., & Fossum, T. W. (2011). Predictive haematological and serum biomarkers for canine endurance exercise. Comparative Exercise Physiology, 7(03), 109–115. https://doi.org/10.1017/S1755254010000310 |
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Grant Number: 00415 Research Program Area: Oncology - Lymphoma |
Anti-HLA-DR Antibody Therapy in Canine B-cell Lymphoma: Preliminary Clinical Evaluation Stein, R., Balkman, C., Chen, S., Rassnick, K., Mcentee, M., Page, R., & Goldenberg, D. M. (2011). Evaluation of anti-human leukocyte antigen-DR monoclonal antibody therapy in spontaneous canine lymphoma. Leukemia & Lymphoma, 52(2), 273–284. https://doi.org/10.3109/10428194.2010.535182 |
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Grant Number: 00859-A Research Program Area: Immunology and Infectious Disease |
Canine Immune-Mediated Hemolytic Anemia Ke, X., Kennedy, L. J., Short, A. D., Seppälä, E. H., Barnes, A., Clements, D. N., … Ollier, W. E. R. (2011). Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. Animal Genetics, 42(2), 181–190. https://doi.org/10.1111/j.1365-2052.2010.02132.x |
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Grant Number: 00888-A Research Program Area: Oncology |
Generation of Canine Single Chain Fragment Variable Antibody Libraries for the Identification and Targeting of Tumor-Associated Antigens in the Dog Braganza, A., Wallace, K., Pell, L., Parrish, C. R., Siegel, D. L., & Mason, N. J. (2011). Generation and validation of canine single chain variable fragment phage display libraries. Veterinary Immunology and Immunopathology, 139(1), 27–40. https://doi.org/10.1016/j.vetimm.2010.07.026
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Grant Number: 0002405 Research Program Area: Musculoskeletal Conditions and Disease |
Inhibition of Collagenolysis in Canine Cranial Cruciate Ligament During Rupture Barrett, J. G., Hao, Z., Graf, B. K., Kaplan, L. D., Heiner, J. P., & Muir, P. (2005). Inflammatory changes in ruptured canine cranial and human anterior cruciate ligaments. American Journal of Veterinary Research, 66(12), 2073–2080. https://doi.org/10.2460/ajvr.2005.66.2073 Bleedorn, J. A., Greuel, E. N., Manley, P. A., Schaefer, S. L., Markel, M. D., Holzman, G., & Muir, P. (2011). Synovitis in Dogs with Stable Stifle Joints and Incipient Cranial Cruciate Ligament Rupture: A Cross-Sectional Study. Veterinary Surgery, 40(5), 531–543. https://doi.org/10.1111/j.1532-950X.2011.00841.x Muir, P., Danova, N. A., Argyle, D. J., Manley, P. A., & Hao, Z. (2005). Collagenolytic Protease Expression in Cranial Cruciate Ligament and Stifle Synovial Fluid in Dogs with Cranial Cruciate Ligament Rupture. Veterinary Surgery, 34(5), 482–490. https://doi.org/10.1111/j.1532-950X.2005.00073.x Muir, P., Manley, P. A., & Hao, Z. (2006). Collagen fragmentation in ruptured canine cranial cruciate ligament explants. The Veterinary Journal, 172(1), 121–128. https://doi.org/10.1016/j.tvjl.2005.03.012 Muir, P., Manley, P. A., & Hao, Z. (2007). COL-3 inhibition of collagen fragmentation in ruptured cranial cruciate ligament explants from dogs with stifle arthritis. The Veterinary Journal, 174(2), 403–406. https://doi.org/10.1016/j.tvjl.2006.07.007 Muir, P., Schamberger, G. M., Manley, P. A., & Hao, Z. (2005). Localization of Cathepsin K and Tartrate-Resistant Acid Phosphatase in Synovium and Cranial Cruciate Ligament in Dogs with Cruciate Disease. Veterinary Surgery, 34(3), 239–246. https://doi.org/10.1111/j.1532-950X.2005.00036.x Muir, P., Schwartz, Z., Malek, S., Kreines, A., Cabrera, S. Y., Buote, N. J., … Hao, Z. (2011). Contralateral Cruciate Survival in Dogs with Unilateral Non-Contact Cranial Cruciate Ligament Rupture. PLoS ONE, 6(10), e25331. https://doi.org/10.1371/journal.pone.0025331 |
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Grant Number: 01083-A Research Program Area: Immunology and Infectious Disease |
Exfoliative Cutaneous Lupus Erythematosus (Lupoid Dermatosis) in the German Shorthaired Pointer Mauldin, E. A., Morris, D. O., Brown, D. C., & Casal, M. L. (2010). Exfoliative cutaneous lupus erythematosus in German Shorthaired Pointer dogs: disease development, progression and evaluation of three immunomodulatory drugs (ciclosporin, hydroxychloroquine, and adalimumab) in a controlled environment. Veterinary Dermatology. 2010;21(4):373-382. doi:10.1111/j.1365-3164.2010.00867.x. Wang, P., Zangerl, B., Werner, P., Mauldin, E. A., & Casal, M. L. (2011). Familial cutaneous lupus erythematosus (CLE) in the German shorthaired pointer maps to CFA18, a canine orthologue to human CLE. Immunogenetics. 2011;63(4):197-207. doi:10.1007/s00251-010-0499-z. |
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Grant Number: 01046-A Research Program Area: Oncology - Osteosarcoma |
The Relevance of Ezrin in the Metastatic Progression of Canine Osteosarcoma Hong, S.-H., Osborne, T., Ren, L., Briggs, J., Mazcko, C., Burkett, S. S., & Khanna, C. (2011). Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells. Veterinary and Comparative Oncology, 9(3), 207–218. https://doi.org/10.1111/j.1476-5829.2010.00249.x |
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Grant Number: 01227-A Research Program Area: Gastrointestinal Disease |
Specificity and Sensitivity of the Pancreatic Lipase Immunoreactivity (SPEC cPL) Test for the Diagnosis of Canine Pancreatitis Trivedi, S., Marks, S. L., Kass, P. H., Luff, J. A., Keller, S. M., Johnson, E. G., & Murphy, B. (2011). Sensitivity and Specificity of Canine Pancreas-Specific Lipase (cPL) and Other Markers for Pancreatitis in 70 Dogs with and without Histopathologic Evidence of Pancreatitis. Journal of Veterinary Internal Medicine, 25(6), 1241–1247. https://doi.org/10.1111/j.1939-1676.2011.00793.x |
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Grant Number: 01192-A Research Program Area: Oncology - Osteosarcoma |
Metabolism and Action of Gemcitabine in Canine Osteosarcoma Cell Lines Rodriguez, C. O., Crabbs, T. A., Wilson, D. W., Cannan, V. A., Skorupski, K. A., Gordon, N., … Anderson, P. M. (2010). Aerosol gemcitabine: preclinical safety and in vivo antitumor activity in osteosarcoma-bearing dogs. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(4), 197–206. https://doi.org/10.1089/jamp.2009.0773 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
