Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01180-A Research Program Area: Neurology |
The Prognostic Value of Various Cerebrospinal Fluid Biomarkers in Dogs with Acute Thoracolumbar Disk Herniation Jeffery, N. D., Levine, J. M., Olby, N. J., & Stein, V. M. (2013). Intervertebral Disk Degeneration in Dogs: Consequences, Diagnosis, Treatment, and Future Directions. Journal of Veterinary Internal Medicine, 27(6), 1318–1333. https://doi.org/10.1111/jvim.12183
Levine, G. J., Levine, J. M., Witsberger, T. H., Kerwin, S. C., Russell, K. E., Suchodolski, J., … Fosgate, G. T. (2010). Cerebrospinal Fluid Myelin Basic Protein as a Prognostic Biomarker in Dogs with Thoracolumbar Intervertebral Disk Herniation. Journal of Veterinary Internal Medicine, 24(4), 890–896. https://doi.org/10.1111/j.1939-1676.2010.0531.x
Witsberger, T. H., Levine, J. M., Fosgate, G. T., Slater, M. R., Kerwin, S. C., Russell, K. E., & Levine, G. J. (2012). Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation. Journal of the American Veterinary Medical Association, 240(5), 555–562. https://doi.org/10.2460/javma.240.5.555
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Grant Number: 00866-A Research Program Area: Ophthalmology |
Phenotypic Characterization Using Electroretinography in Hereditary Retinal Degeneration of English Springer Spaniels Narfström, K., Jeong, M., Hyman, J., Madsen, R. W., & Bergström, T. F. (2012). Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation. Stem Cells International, 2012, 1–12. https://doi.org/10.1155/2012/685901 |
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Grant Number: 00947B Research Program Area: Oncology - Osteosarcoma |
Heritable and Sporadic Genetic Lesions in Canine Osteosarcoma Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., … Subramanian, S. (2012). Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. Bone, 50(1), 171–181. https://doi.org/10.1016/j.bone.2011.10.012
Thomas, R., Wang, H. J., Tsai, P.-C., Langford, C. F., Fosmire, S. P., Jubala, C. M., … Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research, 17(3), 365–377. https://doi.org/10.1007/s10577-009-9028-z
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Grant Number: 982 Research Program Area: Oncology - Osteosarcoma |
Evaluation of Efficacy of Fasaret in Dogs with Osteosarcoma
Modiano, J. F., Bellgrau, D., Cutter, G. R., Lana, S. E., Ehrhart, N. P., Ehrhart, E., … Duke, R. C. (2012). Inflammation, Apoptosis, and Necrosis Induced by Neoadjuvant Fas Ligand Gene Therapy Improves Survival of Dogs With Spontaneous Bone Cancer. Molecular Therapy, 20(12), 2234–2243. https://doi.org/10.1038/mt.2012.149 |
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Grant Number: 0002214T Research Program Area: Oncology |
Identification of a 5-10Mb BAC Set as a Cytogenetic Resource and for the Development of an Ordered CGH Microarray for Cancer Studies in the Dog Breen, M., Hitte, C., Lorentzen, T. D., Thomas, R., Cadieu, E., Sabacan, L., … Ostrander, E. A. (2004). An integrated 4249 marker FISH/RH map of the canine genome. BMC Genomics, 5(65), 11.
Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467
Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613
Rebbeck, C. A., Thomas, R., Breen, M., Leroi, A. M., & Burt, A. (2009). ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER. Evolution, 63(9), 2340–2349. https://doi.org/10.1111/j.1558-5646.2009.00724.x
Thomas, R. (2005). Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Research, 15(12), 1831–1837. https://doi.org/10.1101/gr.3825705
Thomas, R., Bridge, W., Benke, K., & Breen, M. (2003). Isolation and chromosomal assignment of canine genomic BAC clones representing 25 cancer-related genes. Cytogenetic and Genome Research, 102(1–4), 249–253. https://doi.org/10.1159/000075757
Thomas, R., Fiegler, H., Ostrander, E. A., Galibert, F., Carter, N. P., & Breen, M. (2003). A canine cancer-gene microarray for CGH analysis of tumors. Cytogenetic and Genome Research, 102(1–4), 254–260. https://doi.org/10.1159/000075758
Thomas, R, Smith, K. C., Ostrander, E. A., Galibert, F., & Breen, M. (2003). Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes. British Journal of Cancer, 89(8), 1530–1537. https://doi.org/10.1038/sj.bjc.6601275
Thomas, Rachael, Duke, S. E., Bloom, S. K., Breen, T. E., Young, A. C., Feiste, E., … Breen, M. (2007). A Cytogenetically Characterized, Genome-Anchored 10-Mb BAC Set and CGH Array for the Domestic Dog. Journal of Heredity, 98(5), 474–484. https://doi.org/10.1093/jhered/esm053
Thomas, Rachael, Rebbeck, C., Leroi, A. M., Burt, A., & Breen, M. (2009). Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis. Chromosome Research, 17(7), 927–934. https://doi.org/10.1007/s10577-009-9080-8
Tsai, P.-C., & Breen, M. (2012). Array-based comparative genomic hybridization–guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs. American Journal of Veterinary Research, 73(9), 1335–1343. https://doi.org/10.2460/ajvr.73.9.1335 |
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Grant Number: 1312 Research Program Area: Musculoskeletal Conditions and Disease |
Association mapping study of Legg-Calve-Perthes Disease in the West Highland White Terrier, Yorkshire Terrier, and Cairn Terriers Starr-Moss, A. N., Nowend, K. L., Alling, K. M., Zepp, E. J., & Murphy, K. E. (2012). Exclusion of COL2A1 in canine Legg-Calve´- Perthes disease. Animal Genetics, 43(1), 112. https://doi.org/10.1111/j.1365-2052.2011.02215.x
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Grant Number: 1280 Research Program Area: Epilepsy Initiative |
Bromide as Sole Drug Therapy for Treatment of Canine Epilepsy Boothe, D. M., Dewey, C., & Carpenter, D. M. (2012). Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs. Journal of the American Veterinary Medical Association, 240(9), 1073–1083. https://doi.org/10.2460/javma.240.9.1073 |
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Grant Number: 01005-A Research Program Area: Epilepsy Initiative |
A Pilot Study of Intravenous Levetiracetam for Emergency Treatment of Seizures in Dogs Hardy, B. T., Patterson, E. E., Cloyd, J. M., Hardy, R. M., & Leppik, I. E. (2012). Double-Masked, Placebo-Controlled Study of Intravenous Levetiracetam for the Treatment of Status Epilepticus and Acute Repetitive Seizures in Dogs. Journal of Veterinary Internal Medicine, 26(2), 334–340. https://doi.org/10.1111/j.1939-1676.2011.00868.x
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Grant Number: 01365-A Research Program Area: Cardiology |
Multifaceted investigation into the characteristics of degenerative mitral valve disease in Norfolk Terriers: biomarkers, pedigree analysis, and DNA banking - PART 1 Trafny, D. J., Freeman, L. M., Bulmer, B. J., MacGregor, J. M., Rush, J. E., Meurs, K. M., & Oyama, M. A. (2012). Auscultatory, echocardiographic, biochemical, nutritional, and environmental characteristics of mitral valve disease in Norfolk Terriers. Journal of Veterinary Cardiology, 14(1), 261–267. https://doi.org/10.1016/j.jvc.2011.10.002 |
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Grant Number: 2222 Research Program Area: Oncology |
Molecular Control of Prostaglandin Synthesis in Canine Mammary Tumors Doré, M. (2011). Cyclooxygenase-2 Expression in Animal Cancers. Veterinary Pathology, 48(1), 254–265. https://doi.org/10.1177/0300985810379434
Doré, M., Lanthier, I., & Sirois, J. (2003). Cyclooxygenase-2 Expression in Canine Mammary Tumors. Veterinary Pathology, 40(2), 207–212. https://doi.org/10.1354/vp.40-2-207 |
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Grant Number: 01037-A Research Program Area: Musculoskeletal Conditions and Disease |
The Accuracy of Magnetic Resonance Imaging (MRI) for the Diagnosis of Meniscal Lesions in Dogs with Naturally Occurring Cranial Cruciate Ligament Insufficiency Harper, T. A. M., Jones, J. C., Saunders, G. K., Daniel, G. B., Leroith, T., & Rossmeissl, E. (2011). Sensitivity of Low-Field T2* Images for Detecting the Presence and Severity of Histopathologic Meniscal Lesions in Dogs. Veterinary Radiology & Ultrasound, 52(4), 428–435. https://doi.org/10.1111/j.1740-8261.2011.01818.x |
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Grant Number: 00765-A Research Program Area: Neurology |
Mapping the Mutation Responsible for Neuronal Ceroid Lipofuscinosis in Tibetan Terriers Farias, F. H. G., Zeng, R., Johnson, G. S., Wininger, F. A., Taylor, J. F., Schnabel, R. D., … Katz, M. L. (2011). A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan Terriers. Neurobiology of Disease, 42(3), 468–474. https://doi.org/10.1016/j.nbd.2011.02.009 |
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Grant Number: 02405-A Research Program Area: Oncology |
Transcriptome Based Diagnostics in Canine Soft Tissue Sarcoma None at this time. |
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Grant Number: 01077-A Research Program Area: Endocrinology |
Characterization of a P-Type ATPase, an Integral Membrane Protein in Dog Adipose Tissue: a Novel Target for Metabolic Diseases in Mammals Roshwalb, S., Gorman, S., Hurst, S., Bartges, J., Agarwal, S., Sommardahl, C., … Dhar, M. S. (2011). mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score. The Veterinary Journal, 190(1), 173–175. https://doi.org/10.1016/j.tvjl.2010.09.008 |
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Grant Number: 00741 Research Program Area: Musculoskeletal Conditions and Disease |
Polymicrobial Bacteria-Associated Inflammatory Stifle Arthritis/Degenerative Cranial Cruciate Ligament Rupture in Dogs Muir, P., Fox, R., Wu, Q., Baker, T. A., Zitzer, N. C., Hudson, A. P., … Hao, Z. (2010). Seasonal variation in detection of bacterial DNA in arthritic stifle joints of dogs with cranial cruciate ligament rupture using PCR amplification of the 16S rRNA gene. Veterinary Microbiology, 141(1–2), 127–133. https://doi.org/10.1016/j.vetmic.2009.08.015 Muir, P., Kelly, J. L., Marvel, S. J., Heinrich, D. A., Schaefer, S. L., Manley, P. A., … Plisch, E. (2011). Lymphocyte Populations in Joint Tissues from Dogs with Inflammatory Stifle Arthritis and Associated Degenerative Cranial Cruciate Ligament Rupture: Lymphocyte Populations in Joint Tissues. Veterinary Surgery, 40(6), 753–761. https://doi.org/10.1111/j.1532-950X.2011.00867.x Muir, P., Oldenhoff, W. E., Hudson, A. P., Manley, P. A., Schaefer, S. L., Markel, M. D., & Hao, Z. (2007). Detection of DNA from a range of bacterial species in the knee joints of dogs with inflammatory knee arthritis and associated degenerative anterior cruciate ligament rupture. Microbial Pathogenesis, 42(2–3), 47–55. https://doi.org/10.1016/j.micpath.2006.10.002 Schwartz, Z., Zitzer, N. C., Racette, M. A., Manley, P. A., Schaefer, S. L., Markel, M. D., … Muir, P. (2011). Are bacterial load and synovitis related in dogs with inflammatory stifle arthritis? Veterinary Microbiology, 148(2–4), 308–316. https://doi.org/10.1016/j.vetmic.2010.09.011 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
