Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 00876-A Research Program Area: Endocrinology |
Performing a whole genome screen on Rhodesian Ridgebacks with thyroglobulin antibody positive hypothyroid disease Ke, X., Kennedy, L. J., Short, A. D., Seppälä, E. H., Barnes, A., Clements, D. N., … Ollier, W. E. R. (2011). Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. Animal Genetics, 42(2), 181–190. https://doi.org/10.1111/j.1365-2052.2010.02132.x
Quilez, J., Short, A. D., Martínez, V., Kennedy, L. J., Ollier, W., Sanchez, A., … Francino, O. (2011). A selective sweep of >8 Mb on chromosome 26 in the Boxer genome. BMC Genomics, 12(1). https://doi.org/10.1186/1471-2164-12-339 |
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Grant Number: 00762 Research Program Area: Epilepsy Initiative |
The Mapping and Characterization of Canine Epilepsy Loci Katz, M. L., Farias, F. H., Sanders, D. N., Zeng, R., Khan, S., Johnson, G. S., & O’Brien, D. P. (2011). A Missense Mutation in Canine CLN6 in an Australian Shepherd with Neuronal Ceroid Lipofuscinosis. Journal of Biomedicine and Biotechnology, 2011, 1–6. https://doi.org/10.1155/2011/198042 Packer, R. A., Patterson, E. E., Taylor, J. F., Coates, J. R., Schnabel, R. D., & O’Brien, D. P. (2010). Characterization and Mode of Inheritance of a Paroxysmal Dyskinesia in Chinook Dogs: Paroxysmal Dyskinesia. Journal of Veterinary Internal Medicine, 24(6), 1305–1313. https://doi.org/10.1111/j.1939-1676.2010.0629.x Sanders, D. N., Farias, F. H., Johnson, G. S., Chiang, V., Cook, J. R., O’Brien, D. P., … Katz, M. L. (2010). A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund. Molecular Genetics and Metabolism, 100(4), 349–356. https://doi.org/10.1016/j.ymgme.2010.04.009 |
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Grant Number: 01244-A Research Program Area: Neurology |
DRB, DQA, and DQB Gene Sequencing and Allele Determination in the Pug Dog Greer, K. A., Wong, A. K., Liu, H., Famula, T. R., Pedersen, N. C., Ruhe, A., … Neff, M. W. (2010). Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens. https://doi.org/10.1111/j.1399-0039.2010.01484.x
Pedersen, N., Liu, H., Millon, L., & Greer, K. (2011). Dog Leukocyte Antigen Class II–Associated Genetic Risk Testing for Immune Disorders of Dogs: Simplified Approaches Using Pug Dog Necrotizing Meningoencephalitis as a Model. Journal of Veterinary Diagnostic Investigation, 23(1), 68–76. https://doi.org/10.1177/104063871102300110 |
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Grant Number: 976 Research Program Area: Oncology - Osteosarcoma |
Investigating the Role of STAT3 Activation in Canine Osteosarcoma Fossey, S. L., Bear, M. D., Kisseberth, W. C., Pennell, M., & London, C. A. (2011). Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-125 Fossey, S. L., Bear, M. D., Lin, J., Li, C., Schwartz, E. B., Li, P.-K., … London, C. A. (2011). The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-112 Fossey, S. L., Liao, A. T., McCleese, J. K., Bear, M. D., Lin, J., Li, P.-K., … London, C. A. (2009). Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer, 9(1). https://doi.org/10.1186/1471-2407-9-81 |
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Grant Number: 594 Research Program Area: Endocrinology |
Effect of Melatonin on Adrenal Steroids in Dogs with Aberrant Adrenocortical Disease Fecteau, K. A., Eiler, H., & Oliver, J. W. (2011). Effect of combined lignan phytoestrogen and melatonin treatment on secretion of steroid hormones by adrenal carcinoma cells. American Journal of Veterinary Research, 72(5), 675–680. https://doi.org/10.2460/ajvr.72.5.675 |
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Grant Number: 01220-A Research Program Area: Immunology and Infectious Disease |
Determination of Leishmania infantum Infection Rates in U.S. Foxhounds and Neapolitan Mastiffs via Serology and qPCR and Survey of Risk Factors for Visceral Leishmaniasis Boggiatto, P. M., Ramer-Tait, A. E., Metz, K., Kramer, E. E., Gibson-Corley, K., Mullin, K., … Petersen, C. A. (2010). Immunologic Indicators of Clinical Progression during Canine Leishmania infantum Infection. Clinical and Vaccine Immunology, 17(2), 267–273. https://doi.org/10.1128/CVI.00456-09 Boggiatto, Paola Mercedes, Gibson-Corley, K. N., Metz, K., Gallup, J. M., Hostetter, J. M., Mullin, K., & Petersen, C. A. (2011). Transplacental Transmission of Leishmania infantum as a Means for Continued Disease Incidence in North America. PLoS Neglected Tropical Diseases, 5(4), e1019. https://doi.org/10.1371/journal.pntd.0001019
Petersen, C. A. (2009a). Leishmaniasis, an Emerging Disease Found in Companion Animals in the United States. Topics in Companion Animal Medicine, 24(4), 182–188. https://doi.org/10.1053/j.tcam.2009.06.006
Petersen, C. A. (2009b). New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown. Interdisciplinary Perspectives on Infectious Diseases, 2009, 1–5. https://doi.org/10.1155/2009/802712
Petersen, C. A., & Barr, S. C. (2009). Canine Leishmaniasis in North America: Emerging or Newly Recognized? Veterinary Clinics of North America: Small Animal Practice, 39(6), 1065–1074. https://doi.org/10.1016/j.cvsm.2009.06.008
Vida, B., Toepp, A., Schaut, R. G., Esch, K. J., Juelsgaard, R., Shimak, R. M., & Petersen, C. A. (2016). Immunologic progression of canine leishmaniosis following vertical transmission in United States dogs. Veterinary Immunology and Immunopathology, 169, 34–38. https://doi.org/10.1016/j.vetimm.2015.11.008
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Grant Number: 01233-A Research Program Area: Endocrinology |
Examining Hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers Utilizing Whole Genome SNP Association Hughes, A. M., Bannasch, D. L., Kellett, K., & Oberbauer, A. M. (2011). Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. The Veterinary Journal, 187(2), 212–216. https://doi.org/10.1016/j.tvjl.2009.10.012
Wilbe, M., Jokinen, P., Truvé, K., Seppala, E. H., Karlsson, E. K., Biagi, T., … Lindblad-Toh, K. (2010). Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nature Genetics, 42(3), 250–254. https://doi.org/10.1038/ng.525 |
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Grant Number: 01232-A Research Program Area: Oncology - Lymphoma |
Investigation of NF-kB as a Therapeutic Target in Canine Lymphoma
Gaurnier-Hausser, A., Patel, R., Baldwin, A. S., May, M. J., & Mason, N. J. (2011). NEMO-Binding Domain Peptide Inhibits Constitutive NF- B Activity and Reduces Tumor Burden in a Canine Model of Relapsed, Refractory Diffuse Large B-Cell Lymphoma. Clinical Cancer Research, 17(14), 4661–4671. https://doi.org/10.1158/1078-0432.CCR-10-3310 |
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Grant Number: 01018-A Research Program Area: Reproductive Conditions |
Comparative Gene Discovery for Canine Cryptorchidism Zhao, X., Du, Z.-Q., & Rothschild, M. F. (2010). An association study of 20 candidate genes with cryptorchidism in Siberian Husky dogs: Association study of candidate genes with cryptorchidism. Journal of Animal Breeding and Genetics, 127(4), 327–331. https://doi.org/10.1111/j.1439-0388.2010.00859.x |
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Grant Number: 279 Research Program Area: General Canine Health |
Whole Genome Scans Using Multiplexed Microsatellite Markers Greer, K. A., Wong, A. K., Liu, H., Famula, T. R., Pedersen, N. C., Ruhe, A., … Neff, M. W. (2010). Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens. https://doi.org/10.1111/j.1399-0039.2010.01484.x |
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Grant Number: 00395-A Research Program Area: Hepatic Disease |
Elevated Serum Alkaline Phosphatase Activity in Scottish Terriers: Benign Hyperphosphatasemia or an Indicator of Disease? Zimmerman, K. L., Panciera, D. L., Panciera, R. J., Oliver, J. W., Hoffmann, W. E., Binder, E. M., … Kinnarney, J. H. (2010). Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers. Journal of the American Veterinary Medical Association, 237(2), 178–186. https://doi.org/10.2460/javma.237.2.178 |
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Grant Number: 01063-A Research Program Area: Musculoskeletal Conditions and Disease |
Knee Kinematics, Kinetics and Neuromuscular Patterns in Labrador Retrievers at Low Risk to Cranial Cruciate Disease Griffon, D. J. (2010). A Review of the Pathogenesis of Canine Cranial Cruciate Ligament Disease as a Basis for Future Preventive Strategies. Veterinary Surgery, 39(4), 399–409. https://doi.org/10.1111/j.1532-950X.2010.00654.x
Mostafa, A. A., Griffon, D. J., Thomas, M. W., & Constable, P. D. (2010). Morphometric Characteristics of the Pelvic Limb Musculature of Labrador Retrievers with and without Cranial Cruciate Ligament Deficiency. Veterinary Surgery, 39(3), 380–389. https://doi.org/10.1111/j.1532-950X.2010.00657.x
Ragetly, C. A., Griffon, D. J., Mostafa, A. A., Thomas, J. E., & Hsiao-Wecksler, E. T. (2010). Inverse Dynamics Analysis of the Pelvic Limbs in Labrador Retrievers With and Without Cranial Cruciate Ligament Disease. Veterinary Surgery, 39(4), 513–522. https://doi.org/10.1111/j.1532-950X.2010.00680.x
Unis, M. D., Johnson, A. L., Griffon, D. J., Schaeffer, D. J., Ragetly, G. R., Hoffer, M. J., & Ragetly, C. A. (2010). Evaluation of Intra- and Interobserver Variability and Repeatability of Tibial Plateau Angle Measurements with Digital Radiography Using a Novel Digital Radiographic Program. Veterinary Surgery, 39(2), 187–194. https://doi.org/10.1111/j.1532-950X.2009.00641.x |
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Grant Number: 752 Research Program Area: Musculoskeletal Conditions and Disease |
Tissue Expression and Breed-Related Pharmocogenetics of Cytochrome P450 3A12 Akey, J. M., Ruhe, A. L., Akey, D. T., Wong, A. K., Connelly, C. F., Madeoy, J., … Neff, M. W. (2010). Tracking footprints of artificial selection in the dog genome. Proceedings of the National Academy of Sciences, 107(3), 1160–1165. https://doi.org/10.1073/pnas.0909918107
Mealey, K. L., Jabbes, M., Spencer, E., & Akey, J. M. (2008). Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine. Xenobiotica, 38(10), 1305–1312. https://doi.org/10.1080/00498250802446146
Nicholas, T. J., Cheng, Z., Ventura, M., Mealey, K., Eichler, E. E., & Akey, J. M. (2008). The genomic architecture of segmental duplications and associated copy number variants in dogs. Genome Research, 19(3), 491–499. https://doi.org/10.1101/gr.084715.108 |
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Grant Number: 00935B Research Program Area: Oncology |
Positional Cloning of Two Genes for Malignant Histiocytosis (MH) in the Bernese Mountain Dog Abadie, J., Hedan, B., Cadieu, E., De Brito, C., Devauchelle, P., Bourgain, C., … Andre, C. (2009). Epidemiology, Pathology, and Genetics of Histiocytic Sarcoma in the Bernese Mountain Dog Breed. Journal of Heredity, 100(Supplement 1), S19–S27. https://doi.org/10.1093/jhered/esp039
Shearin, A. L., & Ostrander, E. A. (2010). Leading the way: canine models of genomics and disease. Disease Models & Mechanisms, 3(1–2), 27–34. https://doi.org/10.1242/dmm.004358
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Grant Number: 1654 Research Program Area: Musculoskeletal Conditions and Disease |
Mediodistal to Lateroproximal Radiographic View for Early Diagnosis of Fragmentation of the Medial Coronoid Process in Dogs Chanoit, G., Singhani, N. N., Marcellin-Little, D. J., & Osborne, J. A. (2010). Comparison of five radiographic views for assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. American Journal of Veterinary Research, 71(7), 780–783. https://doi.org/10.2460/ajvr.71.7.780
Haudiquet, P. R., Marcellin-Little, D. J., & Stebbins, M. E. (2002). Use of the distomedial-proximolateral oblique radiographic view of the elbow joint for examination of the medial coronoid process in dogs. American Journal of Veterinary Research, 63(7), 1000–1005. https://doi.org/10.2460/ajvr.2002.63.1000 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
