Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 1291 Research Program Area: General Canine Health |
Development of the Genetic Map of the Dog Genome Neff, M. W., Broman, K. W., Mellersh, C. S., Ray, K., Acland, G. M., Aguirre, G. D., … Rine, J. (1999). A Second-Generation Genetic Linkage Map of the Domestic Dog, Canis familiaris. Genetics, 151, 803–820. Retrieved from https://www.genetics.org/content/151/2/803 |
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Grant Number: 0001808A Research Program Area: General Canine Health |
An Integrated Linkage and Radiation Hybrid Map of the Dog: A Collaborative Project Genomics, 84(3), 550–554. https://doi.org/10.1016/j.ygeno.2004.06.006
Mammalian Genome, 15(7). https://doi.org/10.1007/s00335-004-2365-5
Davis, B. W., & Ostrander, E. A. (2014). Domestic Dogs and Cancer Research: A Breed-Based Genomics Approach. ILAR Journal, 55(1), 59–68. https://doi.org/10.1093/ilar/ilu017
Gordon, D. (2003). Establishing Appropriate Genome-Wide Significance Levels for Canine Linkage Analyses. Journal of Heredity, 94(1), 1–7. https://doi.org/10.1093/jhered/esg009
Guyon, R., Lorentzen, T. D., Hitte, C., Kim, L., Cadieu, E., Parker, H. G., … Ostrander, E. A. (2003). A 1-Mb resolution radiation hybrid map of the canine genome. Proceedings of the National Academy of Sciences, 100(9), 5296–5301. https://doi.org/10.1073/pnas.0831002100
Hitte, C. (2003). Comparison of MultiMap and TSP/CONCORDE for Constructing Radiation Hybrid Maps. Journal of Heredity, 94(1), 9–13. https://doi.org/10.1093/jhered/esg012
Hitte, Christophe, Kirkness, E. F., Ostrander, E. A., & Galibert, F. (2008). Survey Sequencing and Radiation Hybrid Mapping to Construct Comparative Maps. Phylogenomics. Methods in Molecular Biology, 422, 65–77. https://doi.org/10.1007/978-1-59745-581-7_5
Hitte, Christophe, Madeoy, J., Kirkness, E. F., Priat, C., Lorentzen, T. D., Senger, F., … Galibert, F. (2005). Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping. Nature Reviews Genetics, 6(8), 643–648. https://doi.org/10.1038/nrg1658
Lingaas, F. (2003). A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Human Molecular Genetics, 12(23), 3043–3053. https://doi.org/10.1093/hmg/ddg336
Miller, A. B., Lowe, J. K., Ostrander, E. A., Galibert, F., & Murphy, K. E. (2001). Cloning, sequence analysis and radiation hybrid mapping of a mammalian KRT 2p gene. Functional & Integrative Genomics, 1(5), 305–311. https://doi.org/10.1007/s101420100038
Murphy, W. J. (2005). Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps. Science, 309(5734), 613–617. https://doi.org/10.1126/science.1111387
Quignon, P., Schoenebeck, J. J., Chase, K., Parker, H. G., Mosher, D. S., Johnson, G. S., … Ostrander, E. A. (2009). Fine Mapping a Locus Controlling Leg Morphology in the Domestic Dog. Cold Spring Harbor Symposia on Quantitative Biology, 74(0), 327–333. https://doi.org/10.1101/sqb.2009.74.009
Richman, M., Mellersh, C. S., André, C., Galibert, F., & Ostrander, E. A. (2001). Characterization of a minimal screening set of 172 microsatellite markers for genome-wide screens of the canine genome. Journal of Biochemical and Biophysical Methods, 47(1–2), 137–149. https://doi.org/10.1016/S0165-022X(00)00160-3
Sargan, D. R., Aguirre-Hernandez, J., Galibert, F., & Ostrander, E. A. (2007). An Extended Microsatellite Set for Linkage Mapping in the Domestic Dog. Journal of Heredity, 98(3), 221–231. https://doi.org/10.1093/jhered/esm006
Sutter, N. B., Bustamante, C. D., Chase, K., Gray, M. M., Zhao, K., Zhu, L., … Ostrander, E. A. (2007). A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs. Science, 316(5821), 112–115. https://doi.org/10.1126/science.1137045 |
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Grant Number: 01054-A Research Program Area: Oncology |
Adult NeurogenesisA Source of Dog Glioblastoma Multiforme (GBMs) Brain Tumor Development Stoica, G., Lungu, G., Martini-STOICA, H., Waghela, S., Levine, J., & Smith, R. (2009). Identification of Cancer Stem Cells in Dog Glioblastoma. Veterinary Pathology, 46(3), 391–406. https://doi.org/10.1354/vp.08-VP-0218-S-FL |
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Grant Number: 919 Research Program Area: Kidney & Urological Disease |
Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests Bannasch, D., & Henthorn, P. S. (2009). Changing Paradigms in Diagnosis of Inherited Defects Associated with Urolithiasis. Veterinary Clinics of North America: Small Animal Practice, 39(1), 111–125. https://doi.org/10.1016/j.cvsm.2008.09.006
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Grant Number: 2458 Research Program Area: Kidney & Urological Disease |
Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests Bannasch, D., & Henthorn, P. S. (2009). Changing Paradigms in Diagnosis of Inherited Defects Associated with Urolithiasis. Veterinary Clinics of North America: Small Animal Practice, 39(1), 111–125. https://doi.org/10.1016/j.cvsm.2008.09.006 |
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Grant Number: 01178-A Research Program Area: Oncology - Osteosarcoma |
Radiosensitization of Canine Osteosarcoma with Rapamycin Lurie, D. M., Gordon, I. K., Théon, A. P., Rodriguez, C. O., Suter, S. E., & Kent, M. S. (2009). Sequential low-dose rate half-body irradiation and chemotherapy for the treatment of canine multicentric lymphoma. Journal of Veterinary Internal Medicine, 23(5), 1064–1070. https://doi.org/10.1111/j.1939-1676.2009.0353.x
Lurie, D. M., Kent, M. S., Fry, M. M., & Théon, A. P. (2008, December 1). A toxicity study of low?dose rate half?body irradiation and chemotherapy in dogs with lymphoma. https://doi.org/10.1111/j.1476-5829.2008.00164.x |
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Grant Number: 678 Research Program Area: Oncology |
Generation and Analysis of Canine Bone Marrow Derived Mast Cells Lin, T., Rush, L. J., & London, C. A. (2006). Generation and characterization of bone marrow-derived cultured canine mast cells. Veterinary Immunology and Immunopathology, 113(1–2), 37–52. https://doi.org/10.1016/j.vetimm.2006.03.024
Lin, T.-Y., & London, C. A. (2006). A functional comparison of canine and murine bone marrow derived cultured mast cells. Veterinary Immunology and Immunopathology, 114(3–4), 320–334. https://doi.org/10.1016/j.vetimm.2006.09.001
Lin, T.-Y., Thomas, R., Tsai, P.-C., Breen, M., & London, C. A. (2009). Generation and characterization of novel canine malignant mast cell line CL1. Veterinary Immunology and Immunopathology, 127(1–2), 114–124. https://doi.org/10.1016/j.vetimm.2008.09.027
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Grant Number: 1270 Research Program Area: Kidney & Urological Disease |
Hereditary Nephritis in English Cocker Spaniels Bell, R. J., Lees, G. E., & Murphy, K. E. (2008). X chromosome inactivation patterns in normal and X-linked hereditary nephropathy carrier dogs. Cytogenetic and Genome Research, 122(1), 37–40. https://doi.org/10.1159/000151314
Burkholder, W. J., Lees, G. E., LeBlanc, A. K., Slater, M. R., Bauer, J. E., Kashtan, C. E., … Hannah, S. S. (2004). Diet Modulates Proteinuria in Heterozygous Female Dogs with X-Linked Hereditary Nephropathy. Journal of Veterinary Internal Medicine, 18, 165–175. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15058767
Cox, M. L., Lees, G. E., Kashtan, C. E., & Murphy, K. E. (2003). Genetic cause of X-linked Alport syndrome in a family of domestic dogs. Mammalian Genome, 14(6), 396–403. https://doi.org/10.1007/s00335-002-2253-9
Cox, M., Quignon, P., Galibert, F., Lees, G., & E. Murphy, K. (2009). Sequencing and Radiation Hybrid Mapping of Canine Uromodulin. DNA Sequence, 14, 61–69. https://doi.org/10.1080/1042517021000056943
Davidson, A. G., Bell, R. J., Lees, G. E., Kashtan, C. E., Davidson, G. S., & Murphy, K. E. (2007). Genetic Cause of Autosomal Recessive Hereditary Nephropathy in the English Cocker Spaniel. Journal of Veterinary Internal Medicine, 21, 394–401. Retrieved from https://doi.org/10.1111/j.1939-1676.2007.tb02981.x
Greer, K. A., Higgins, M. A., Cox, M. L., Ryan, T. P., Berridge, B. R., Kashtan, C. E., … Murphy, K. E. (2006). Gene expression analysis in a canine model of X-linked Alport syndrome. Mammalian Genome, 17(9), 976–990. https://doi.org/10.1007/s00335-005-0179-8
Kashtan, C. E., Kim, Y., Lees, G. E., Thorner, P. S., Virtanen, I., & Miner, J. H. (2001). Abnormal Glomerular Basement Membrane Laminins in Murine, Canine, and Human Alport Syndrome. Journal of the American Society of Nephrology, 12(2), 252–260. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/11158215
Lees, G. E., Helman, R. G., Kashtan, C. E., Michael, A. F., Homco, L. D., Millichamp, N. J., … Kim, Y. (1999). New form of X-linked dominant hereditary nephritis in dogs. American Journal of Veterinary Research, 60(3), 373–383. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10188823
Lees, George E. (1996). Congenital Renal Diseases. Veterinary Clinics of North America: Small Animal Practice, 26(6), 1379–1399. https://doi.org/10.1016/S0195-5616(96)50133-6
Lees, George E. (2004). Early diagnosis of renal disease and renal failure. Veterinary Clinics of North America: Small Animal Practice, 34(4), 867–885. https://doi.org/10.1016/j.cvsm.2004.03.004
Lees, George E., Helman, R. G., Kashtan, C. E., Michael, A. F., Homco, L. D., Millichamp, N. J., … Kim, Y. (1998). A model of autosomal recessive Alport syndrome in English cocker spaniel dogs. Kidney International, 54(3), 706–719. https://doi.org/10.1046/j.1523-1755.1998.00062.x
Lees, George E., Kashtan, C. E., Michael, A. F., Helman, R. G., Naito, I., Ninomiya, Y., … Kim, Y. (2000). Expression of the α6 chain of type IV collagen in glomerular basement membranes of healthy adult dogs. American Journal of Veterinary Research, 61(1), 38–41. https://doi.org/10.2460/ajvr.2000.61.38 |
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Grant Number: 00683-A Research Program Area: Blood Disorders |
Evaluation of Laboratory Methods to Improve Characterization of Dogs With von Willebrand Disease Burgess, H. J., Woods, J. P., Abrams-Ogg, A. C. G., & Wood, R. D. (2009). Use of a questionnaire to predict von Willebrand disease status and characterize hemorrhagic signs in a population of dogs and evaluation of a diagnostic profile to predict risk of bleeding. The Canadian Journal of Veterinary Research, 73, 241–251.
Burgess, H. J., Woods, J. P., Abrams-Ogg, A. C. G., & Wood, R. D. (n.d.). Evaluation of laboratory methods to improve characterization of dogs with von Willebrand disease. 8.
Burgess, H., & Wood, D. (2008). Validation of a von Willebrand factor antigen enzyme-linked immunosorbent assay and newly developed collagen-binding assay. The Canadian Journal of Veterinary Research, 72, 420–427. |
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Grant Number: 01197-A Research Program Area: Dermatology and Allergic Disease |
Genetic Analysis of Alopecia X in Pomeranians and Keeshonden Fatima Wingeier (2009) Alopecia X in Pomeranians - A Genome Wide Association Analysis. Master Thesis. Faculty of Natural Sciences, University of Bern. Mausberg, E.-M., Drögemüller, C., Dolf, G., Leeb, T., Rüfenacht, S., & Welle, M. (2007). Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden. Animal Biotechnology, 18(4), 291–296. https://doi.org/10.1080/10495390701547461
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Grant Number: 00858-A Research Program Area: Cardiology |
Evaluation of Novel Diagnostic and Therapeutic Modalities for Treatment of Canine Pulmonary Hypertension Atkinson, K. J., Fine, D. M., Thombs, L. A., Gorelick, J. J., & Durham, H. E. (2009). Evaluation of Pimobendan and N-Terminal Probrain Natriuretic Peptide in the Treatment of Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease in Dogs. Journal of Veterinary Internal Medicine, 23(6), 1190–1196. https://doi.org/10.1111/j.1939-1676.2009.0390.x |
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Grant Number: 00986-A Research Program Area: General Canine Health |
Human and Pet Canine Nutrition Relationships Heuberger, R. A., & Glassman, K. D. (2009). Survey of dietary patterns and health in community dwelling canines. Journal of Animal Physiology and Animal Nutrition, 93(2), 143–144. https://doi.org/10.1111/j.1439-0396.2009.00921_5.x |
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Grant Number: 00718-A Research Program Area: Oncology |
Ras Mutations in Canine Lymphoid and Myeloid Leukemias Usher, S. G., Radford, A. D., Villiers, E. J., & Blackwood, L. (2009). RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias. Experimental Hematology, 37(1), 65–77. https://doi.org/10.1016/j.exphem.2008.09.005 |
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Grant Number: 00640T Research Program Area: Neurology |
Linkage Disequilibrium Analysis of Markers Associated with Pug Dog Encephalitis Greer, K. A., Wong, A. K., Liu, H., Famula, T. R., Pedersen, N. C., Ruhe, A., … Neff, M. W. (2010). Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens. https://doi.org/10.1111/j.1399-0039.2010.01484.x
Greer, Kimberly A., Schatzberg, S. J., Porter, B. F., Jones, K. A., Famula, T. R., & Murphy, K. E. (2009). Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug. Research in Veterinary Science, 86(3), 438–442. https://doi.org/10.1016/j.rvsc.2008.10.002
Levine, J. M., Fosgate, G. T., Porter, B., Schatzberg, S. J., & Greer, K. (2008). Epidemiology of Necrotizing Meningoencephalitis in Pug Dogs. Journal of Veterinary Internal Medicine, 22(4), 961–968. https://doi.org/10.1111/j.1939-1676.2008.0137.x
Young, B. D., Levine, J. M., Fosgate, G. T., de Lahunta, A., Flegel, T., Matiasek, K., … Schatzberg, S. J. (2009). Magnetic Resonance Imaging Characteristics of Necrotizing Meningoencephalitis in Pug Dogs. Journal of Veterinary Internal Medicine, 23(3), 527–535. https://doi.org/10.1111/j.1939-1676.2009.0306.x |
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Grant Number: 01213-A Research Program Area: Neurology |
Determination of Outcome Measures for Clinical Progression and Morphometric Studies of Spinal Cord Disease in Degenerative Myelopathy Dogs Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
