Tick-borne Disease Initiative

About the Tick-Borne Disease Research Initiative


The AKC Canine Health Foundation (CHF) Tick-Borne Disease Research Initiative was created in 2016 to address the growing threat of tick-borne disease to canine and human health. Disease occurs when ticks infected with a pathogen directly bites a dog or human and transmit the pathogen into the body. Many tick-borne pathogens infect dogs and can also infect humans. The geographic distribution of ticks is spreading and can change yearly by season and region of the United States. CHF is taking a One Health action to address the prevalence, diagnosis, and treatment of tick-borne disease. The most important tick-borne diseases of dogs are Ehrlichiosis, Anaplasmosis, Rocky Mountain spotted fever, Hepatozoonosis, Babesiosis, Bartonellosis, Hemotropic Mycoplasmosis, and Lyme disease. All can have serious health consequences, and infection rates have been on the rise over the past five years. The feeding time required for disease transmission from a tick to a dog or person can be as little as 3 – 6 hours!

Since 1995, CHF and its donors have invested more than $754,000 in 10 grants to study tick-borne disease. Current grants explore better methods to detect tick-borne diseases and recognize new pathogens, plus improve our understanding of how ticks locate dog hosts and how the canine immune system responds to tick-borne infections.

$754K invested in tick-borne disease research since 1995.

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Learn More about the Initiative

Learn more about the Tick-Borne Disease Research Initiative (starting 7:50) by AKCtv's Ask the Expert: Epilepsy and Tick-borne Disease with former CHF CEO, Dr. Diane Brown.

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Why Study It?

    • The geographical range of tick species in North America is expanding
    • The incidence of tick-borne diseases reported in dogs and humans continues to rise
    • To understand why some infected dogs remain asymptomatic, while others develop life-threatening illness
    • Dogs infected with tick-borne disease agents can act as sentinels for the same diseases in people
    • Accurate diagnosis of co-infections (simultaneous infection with multiple vector-borne organisms) will facilitate early and comprehensive treatment
    • Understanding which immune cells are responsible for the successful cure of a tick-borne infection may provide a target for treatment in all infected dogs
    • Prevention is key for tick-borne disease; Strategies to improve tick control will improve the health of dogs and humans living in at-risk areas



    Our Progress So Far


    Current CHF-Funded Studies

    The AKC Canine Health Foundation (CHF) believes in the advancement of science to meet the unmet medical needs of the dogs that are such an important part of our daily lives. Here we list the important active studies in this research program area.

     02831 Mechanisms of NK(T) Cell Mediated Inflammation during Canine Lyme Disease
     02819 Identification of Bartonella henselae In Vivo Induced Antigens for Development of a Reliable Serodiagnostic Assay for Canine Bartonelloses
     02553 Targeted next generation sequencing panel for comprehensive testing of vector-borne pathogens
     02528 Developing a Next Generation Sequencing Diagnostic Platform for Tickborne Diseases
     02386-A Surveillance of Hepatozoon americanum In Populations of the Gulf Coast Tick Vector



     02383 Identifying Cellular Mechanisms of Inflammation During Canine Tick‐Borne Diseases
     02292 Broad-Range Detection of Canine Tick-Borne Disease and Improved Diagnostics Using Next-Generation Sequencing
     02287 Enhanced Testing for the Diagnosis of Bartonellosis in Dogs
     01780 Defining the Mechanism by Which Ticks Locate Dogs in Order to Better Prevent Disease Transmission
     02295-A The Role of Lymphocytes in Canine Monocytic Ehrlichiosis
     02285-A Thrombocytopenia and Occult Vector-Borne Disease in Greyhound Dogs: Implications for Clinical Cases and Blood Donors
     02284-A Lyme Disease in Dogs: Prevalence, Clinical Illness, and Prognosis

    Resources

    Webinars:

     

    Podcast: Dr. Diane Brown, CHF CEO, spoke with Pure Dog Talk in 2018 for this podcast on Researching Connections Between Ticks and Cancer. Listen to the podcast here.

    Center for Disease Control and Prevention: Ticks

    Pet Health Network: Keep your dog safe from tick-borne disease. Learn about the ticks and diseases in your area from the Pet Health Network.

     

    Associated publications:

    • A Cross-sectional Study of Vector-borne Pathogens in Canadian Dogs. Read this publication from our colleagues and CHF-funded investigators Drs. Evason and Stull.
    • Luck, Labor, and a Labrador Retriever: A Veterinarian’s Journey into Bartonella Research. An interview with Dr. Ed Breitschwerdt conducted by Sam Lin, July 2017.
    • Protecting Dogs Against Ticks. Featured in Today’s Breeder – Issue 95, courtesy of Purina Pro Plan.
    • Tick-Borne Disease: Prevalence, Prevention and Treatment. Read CHF's whitepaper to learn more about ticks, tick-borne diseases, and how to keep your dog safe.
    • Lyme-Bearing Ticks More Widespread in U.S. Than Thought. Read HealthDay's 2018 article on tick prevalence and distribution.

    Articles

    Publications

    Researchers awarded grants through CHF continue to produce a wealth of publications contributing to scientific knowledge. These scientific articles, grouped by publication date, are a result of CHF-funded tick-borne disease research!


    • Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology. https://doi.org/10.1128/JCM.01335-19
    • Duncan, A. W., Marr, H. S., Birkenheuer, A. J., Maggi, R. G., Williams, L. E., Correa, M. T., & Breitschwerdt, E. B. (2008). Bartonella DNA in the Blood and Lymph Nodes of Golden Retrievers with Lymphoma and in Healthy Controls. Journal of Veterinary Internal Medicine, 22(1), 89–95. https://doi.org/10.1111/j.1939-1676.2007.0018.x
    • Neupane, P., Hegarty, B. C., Marr, H. S., Maggi, R. G., Birkenheuer, A. J., & Breitschwerdt, E. B. (2018). Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15301
    • Kidd, L., Qurollo, B., Lappin, M., Richter, K., Hart, J. R., Hill, S., Osmond, C., & Breitschwerdt, E. B. (2017). Prevalence of Vector-Borne Pathogens in Southern California Dogs With Clinical and Laboratory Abnormalities Consistent With Immune-Mediated Disease. Journal of Veterinary Internal Medicine, 31(4), 1081–1090. https://doi.org/10.1111/jvim.14735
    • Trout Fryxell, Rebecca T., Hendricks, B. M., Pompo, K., Mays, S. E., Paulsen, D. J., Operario, D. J., & Houston, A. E. (2017). Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma, Ehrlichia, and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. Vector-Borne and Zoonotic Diseases, 17(8), 527–538. https://doi.org/10.1089/vbz.2016.2091
    • Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016). Specifying Pathogen Associations of Amblyomma maculatum (Acari: Ixodidae) in Western Tennessee. Journal of Medical Entomology, 53(2), 435–440. https://doi.org/10.1093/jme/tjv238
    • Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016). Comparison of novel and conventional methods of trapping ixodid ticks in the southeastern U.S.A. Medical and Veterinary Entomology, 30(2), 123–134. https://doi.org/10.1111/mve.12160
    • Trout Fryxell, R. T., Moore, J. E., Collins, M. D., Kwon, Y., Jean-Philippe, S. R., Schaeffer, S. M., Odoi, A., Kennedy, M., & Houston, A. E. (2015). Habitat and Vegetation Variables Are Not Enough When Predicting Tick Populations in the Southeastern United States. PLOS ONE, 10(12), e0144092. https://doi.org/10.1371/journal.pone.0144092


    • Mays, Sarah E, Hendricks, B. M., Paulsen, D. J., Houston, A. E., & Fryxell, R. T. T. (2014). Prevalence of five tick-borne bacterial genera in adult Ixodes scapularis removed from white-tailed deer in western Tennessee. Parasites and Vectors, 7, 473. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207311/
    • Barber, R. M., Li, Q., Diniz, P. P. V. P., Porter, B. F., Breitschwerdt, E. B., Claiborne, M. K., Birkenheuer, A. J., Levine, J. M., Levine, G. J., Chandler, K., Kenny, P., Nghiem, P., Wei, S., Greene, C. E., Kent, M., Platt, S. R., Greer, K., & Schatzberg, S. J. (2010). Evaluation of Brain Tissue or Cerebrospinal Fluid with Broadly Reactive Polymerase Chain Reaction for Ehrlichia, Anaplasma , Spotted Fever Group Rickettsia, Bartonella, and Borrelia Species in Canine Neurological Diseases (109 Cases). Journal of Veterinary Internal Medicine, 24(2), 372–378. https://doi.org/10.1111/j.1939-1676.2009.0466.x
    • Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Koehler, J. E., MacDonald, K. A., Kittleson, M. D., Thomas, W. P., & Chomel, B. B. (2009). Infective Endocarditis in a Dog and the Phylogenetic Relationship of the Associated “Bartonella rochalimae” Strain with Isolates from Dogs, Gray Foxes, and a Human. Journal of Clinical Microbiology, 47(3), 787–790. https://doi.org/10.1128/JCM.01351-08
    • Henn, Jennifer B., Chomel, B. B., Boulouis, H.-J., Kasten, R. W., Murray, W. J., Bar-Gal, G. K., King, R., Courreau, J.-F., & Baneth, G. (2009). Bartonella rochalimae in Raccoons, Coyotes, and Red Foxes. Emerging Infectious Diseases, 15(12), 1984–1987. https://doi.org/10.3201/eid1512.081692
    • Hawkins, E. C., Johnson, L. R., Guptill, L., Marr, H. S., Breitschwerdt, E. B., & Birkenheuer, A. J. (2008). Failure to identify an association between serologic or molecular evidence of Bartonella infection and idiopathic rhinitis in dogs. Journal of the American Veterinary Medical Association, 233(4), 597–599. https://doi.org/10.2460/javma.233.4.597
    • Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Theis, J. H., Foley, J. E., & Chomel, B. B. (2007). Gray Foxes (Urocyon cinereoargenteus) as a Potential Reservoir of a Bartonella clarridgeiae-Like Bacterium and Domestic Dogs as Part of a Sentinel System for Surveillance of Zoonotic Arthropod-Borne Pathogens in Northern California. Journal of Clinical Microbiology, 45(8), 2411–2418. https://doi.org/10.1128/JCM.02539-06



    How to Get Involved


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    Sponsor the Tick-Borne Disease Research Initiative

    Sponsor today at a $2,500+ level!

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    Thank you to the Sponsors of the Tick-Borne Disease Research Initiative!

    Champion Sponsors ($50,000+)

       
    Ms. Kiki Courtelis

    Sponsors ($2,500+)

    Afghan Hound Club of America, Inc.
    Alaskan Malmute Club of America, Inc.
    American Brittany Club
    American Boxer Charitable Foundation
    American Field Pointer Association
    American Field Setter Association
    American Pointer Club
    American Shih Tzu Club Charitable Trust
    American Shih Tzu Club, Inc.
    American Whippet Club, Inc.
    Australian Terrier Club of America
    Basset Hound Club of America
    Bearded Collie Club of America
    Border Terrier Club of America
    Bull Terrier Club of America
    Clumber Spaniel Health Foundation
    Cyclone County Kennel Club of Ames, Inc.
    Eastern German Shorthaired Pointer Club, Inc.
    English Setter Association of America, Inc.
    Field Spaniel Society of America
    German Shorthaired Pointer Club of America, Inc.
    Golden Retriever Foundation
    Gordon Setter Club of America, Inc.
    Great Pyrenees Club of America
    Greater Swiss Mountain Dog Club of America, Inc.
    Greyhound Club of America
    Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America
    Irish Setter Club of America Foundation, Inc.
    Irish Wolfhound Club of America, Inc.
    Keeshond Club of America,
    Labrador Retriever Club, Inc.
    LEAP Agility
    National Amateur Retriever Club
    National Springer Spaniel Field Trial Association
    Newfoundland Club of America Charitable Trust
    Norwegian Elkhound Association of America, Inc.
    Parson Russell Terrier Association of America
    Pembroke Welsh Corgi Club of America
    Pembroke Welsh Corgi Club of America Charitable Trust
    Portuguese Water Dog Foundation Inc.
    Retriever News / Entry Express
    Rhodesian Ridgeback Charitable Foundation
    Rottweiler Health Foundation
    Samoyed Club of America Education & Research
    Scottish Terrier Club of America
    Siberian Husky Club of America, Inc.
    Soft Coated Wheaten Terrier Club of America, Inc.
    Staffordshire Terrier Club of America, Inc.
    TarTan Gordon Setter Club
    Tibetan Terrier Club of America/Tibetan Terrier Health & Welfare Foundation
    Treeing Walker Breeders & Fanciers Association
    United States Australian Shepherd Foundation
    Welsh Springer Spaniel Club of America, Inc.

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