Hemangiosarcoma Research Initiative

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|What is Hemangiosarcoma?| Why Study it?| CHF Studies | AKC Match Challenge | Publications | Webinars | Sponsors of the Hemangiosarcoma Initiative |

What is Hemangiosarcoma? 

  • An aggressive and common cancer in dogs.
  • While the cause of the disease is unknown, certain breeds (Golden Retriever, Portuguese Water Dog, Boxer, German Shepherd Dog) are considered to be high-risk. This suggests that heritable traits, while not singularly responsible, may contribute to the disease.
  • Hemangiosarcoma can develop in any tissue or organ, but the most common primary sites for these tumors include spleen, right atrium of the heart, and the skin.

Why study it? 

  • While cutaneous masses (affecting the skin) are often treatable by tumor excision, tumors affecting internal organs are associated with poorer prognosis and are almost always incurable.
  • Hemangiosarcoma is often called the “silent killer” because the tumors are often not detected until the later stages of the disease, and even dogs harboring large tumors may show no clinical signs or evidence that they have a life threatening disease.
  • Because treatments have not improved the overall survival times for dogs with this disease, tremendous efforts are being made through research funded by the CHF and its donors to gain a better understanding of the biology and progression of this disease with the goal to design new and effective approaches to treatment.

Current CHF Studies: 

02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
Principal Investigator: Erin B. Dickerson, PhD; University of Minnesota
Co-investigators: David R. Brown, PhD; University of Minnesota, Michael O. Childress, DVM, MS; Purdue University, Jennifer Mahoney, DVM and Pascale Salah; University of Pennsylvania
Total Grant Amount: $310,790; Grant Period: 7/1/2019 - 6/30/2022

02234-MOU: A Novel Approach for Prevention of Canine Hemangiosarcoma
Principal Investigator: Jaime F Modiano, VMD, PhD; University of Minnesota
Total Grant Amount: $432,000; Grant Period: 3/1/2016 - 2/29/2020

02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations
Principal Investigator: Edward B Breitschwerdt, DVM; Matthew Breen, PhD; North Carolina State University
Total Grant Amount: $219,026; Grant Period: 2/1/2018 - 1/31/2020

02510: Identification of Novel Synthetic Lethal Partners to Optimize PI3K Targeted Therapies in Canine Hemangiosarcoma
Principal Investigator: Cheryl A. London, DVM PhD; Tufts Medical Center
Total Grant Amount: $168,857; Grant Period: 3/1/2018 - 2/28/2021 

Previous CHF Studies:

02217: A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma
Principal Investigator: Erin B. Dickerson, PhD; University of Minnesota
Total Grant Amount: $86,206.00; Grant Period: 1/1/2016 - 6/30/2018

 

AKC Match Challenge

You’ve helped us meet the $250,000 AKC Canine Cancer Research Initiative match for 2019!

 

GOOD NEWS! Staring October 1, 2019, the American German Shepherd Dog Charitable Foundation will generously match donations the Hemangiosarcoma Research Initiative up to $33,500 as part of a three-year, $100,000 pledge to fight this devastating cancer.

Learn more at akcchf.org/match.


 

 

Publications on Hemangiosarcoma from CHF Studies:

Watch the January 9, 2019 AKC.TV Ask the Expert interview with AKC Canine Health Foundation CEO, Dr. Diane Brown, discussing our Hemangiosarcoma Research Initiative here.

 

Webinars:

Prevention Strategies for Canine Hemangiosarcoma?

See what Douglas H. Thamm, VMD, DACVIM (Oncology) has to say about cancer prevention as well as what we know about the connection between the use of vaccines, flea, tick and heartworm preventatives and cancer risk in dogs.

Update on Canine Hemangiosarcoma

Douglas H. Thamm, VMD, DACVIM (Oncology) presents on:

  •     The clinical presentation, staging, therapy and prognosis in canine hemangiosarcoma
  •     Recent findings about the biology of the disease
  •     Early diagnosis and new treatment strategies
 

Thank you to the sponsors of the Hemangiosarcoma Initiative!

Champion Sponsors ($50,000+)

 

 

 

 

 

Sponsors ($2,500+)

Alaskan Malamute Club of America, Inc.
American Belgian Tervuren Club, Inc.
American Bloodhound Club
American Bullmastiff Association
American Pointer Club
Australian Shepherd Health & Genetics Institute, Inc.
Australian Terrier Trust
Basset Hound Club of America, Inc.
Bedlington Terrier Club of America
Bernese Mountain Dog Club of America
Bouvier Health Foundation
Briard Club of America Health & Education Trust
Chesapeake Kennel Club of Maryland, Inc.
Clumber Spaniel Health Foundation
Dachshund Club of America, Inc.
Flat-Coated Retriever Foundation
French Bulldog Club of America
Golden Retriever Club of San Diego County
German Shorthaired Pointer Club of America, Inc.
German Wirehaired Pointer Club of America
Gordon Setter Club of America, Inc.
Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America
Irish Setter Club of America Foundation, Inc.
Irish Setter Club of Milwaukee
Irish Wolfhound Club of America, Inc.
Keeshond Club of America
Labrador Retriever Club, Inc.
Leonberger Health Foundation
Master National Retriever Club Foundation
Miranda Fund
Nespola Charitable Foundation
Newfoundland Club of America Charitable Trust
Poodle Club of America Foundation
Rottweiler Health Foundation
Saluki Health Research, Inc.
Scottish Terrier Club of America Health Trust Fund
Soft Coated Wheaten Terrier Club of America Endowment, Inc.
Versatility in Poodles, Inc.
Vizsla Club of America Welfare Foundation
Weimaraner Foundation Fund Corporation

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Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

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