00812-A: Investigation of the Canine Cathepsin L Gene (CTSL) as a Candidate for Alopecia X in Keeshonden and Pomeranians

Grant Status: Closed

Grant Amount: $12,600
Tosso Leeb, PhD; University of Bern
December 1, 2006 - May 31, 2007

Sponsor(s): Pug Dog Club of America, Inc.

Breed(s): Pomeranian, Keeshond, Samoyed, Chow Chow, Alaskan Malamute
Research Program Area: Dermatology and Allergic Disease
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Project Summary

Alopecia X is a noninflammatory, progressive, bilateral symmetric alopecia in dogs. The disease is mainly found in Nordic breeds. The breed predisposition and a strong familial accumulation suggest a hereditary background. We analyzed the cathepsin L2 gene (CTSL2) as a candidate for alopecia X. The comparative sequencing of 14 affected and 18 control animals revealed ten polymorphisms; however, none of these polymorphisms affected the coding sequence. Haplotype analysis did not reveal an association of one particular CTSL2 haplotype with the disease phenotype; therefore, we conclude that the CTSL2 gene is probably not the causative gene for alopecia X.

Publication(s)

Mausberg, E.-M., Drögemüller, C., Dolf, G., Leeb, T., Rüfenacht, S., & Welle, M. (2007). Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden. Animal Biotechnology, 18(4), 291–296. https://doi.org/10.1080/10495390701547461

Mausberg, E.-M., Drogemuller, C., Dolf, G., Rufenacht, S., Welle, M., & Leeb, T. (2008). Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden. Veterinary Record, 163(4), 121–123. https://doi.org/10.1136/vr.163.4.121

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