00718-A: Ras Mutations in Canine Lymphoid and Myeloid Leukemias

Grant Status: Closed

Grant Amount: $10,800
Dr. Laura Blackwood, Ph.D., University of Liverpool
March 1, 2006 - February 28, 2007
Breed(s): -All Dogs
Research Program Area: Treatment

Abstract

Ras is the most frequently mutated oncogene in human cancer, and ras mutations are seen in up to 20 percent of patients with acute lymphoid leukemia, and 20-44 percent of patients with acute myeloid leukaemia. These mutations provide a proliferative signal by activation of the RTK/ras signalling pathways, and in human patients the presence or absence of these mutations is associated with prognosis and chemosensitivity. The molecular genetics of canine leukemia are undefined. We hypothesize that ras mutations are likely to occur in canine leukemias and our objective is to identify and characterize these mutations and determine their frequency and significance.

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