1291: Development of the Genetic Map of the Dog Genome

Grant Status: Closed

Grant Amount: $217,695
Jasper Rine, PhD; University of California, Berkeley
June 17, 1996 - June 16, 1999

Sponsor(s): Helen Chrysler Greene

Breed(s): -All Dogs
Research Program Area: General Canine Health
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Project Summary

In collaboration with other scientists, the researchers on this project published the second-generation dog genome map. That map nearly doubled the number of markers on its predecessor, and almost 90 percent of the new data on the second-generation map were generated by the principal investigator�s laboratory. Researchers also collected DNA from a variety of breeds and used the marker information gathered to expand the dog genome map and make it easier to use. They assembled 32 multiplex sets comprised of 187 markers and tested these sets on several breeds and several large families. These "kits" have been made available to colleagues. The kits facilitate linkage analysis by saving time and money while increasing productivity. The researchers used the marker sets to map chondrodysplasia in Beagles.

Publication(s)

Neff, M. W., Broman, K. W., Mellersh, C. S., Ray, K., Acland, G. M., Aguirre, G. D., … Rine, J. (1999). A Second-Generation Genetic Linkage Map of the Domestic Dog, Canis familiaris. Genetics, 151, 803–820. Retrieved from https://www.genetics.org/content/151/2/803

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