2458: Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests

Grant Status: Closed

Grant Amount: $68,972.91
Paula S. Henthorn, PhD; University of Pennsylvania
July 1, 2003 - June 30, 2005

Sponsor(s): Pug Dog Club of America, Inc.

Breed(s): Mastiff
Research Program Area: Kidney & Urological Disease
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Abstract

Cystinuria is an inherited disease that has been long recognized in dogs and has been documented in nearly 70 breeds. Our previous studies made significant progress with a form of cystinuria that is clinically manifested at an early age such that we can go from seeing an affected animal in the clinic to a DNA-based test in a matter of weeks. We now have access to sufficient pedigrees to make similar progress for cystinuria that presents at a later age, and probably represents a more common form of the disease. Genetic testing is even more important for a disease that has a later age of onset.

Publication(s)

Bannasch, D., & Henthorn, P. S. (2009). Changing Paradigms in Diagnosis of Inherited Defects Associated with Urolithiasis. Veterinary Clinics of North America: Small Animal Practice, 39(1), 111–125. https://doi.org/10.1016/j.cvsm.2008.09.006

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