279: Whole Genome Scans Using Multiplexed Microsatellite Markers

Grant Status: Closed

Grant Amount: $100,000
Niels C Pedersen, PhD; University of California, Davis
July 1, 2004 - June 30, 2008


Breed(s): -All Dogs
Research Program Area: General Canine Health
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Veterinary clinicians, usually in concert with their breeder clients, are the first people to recognize novel deleterious traits in purebred dogs and to suspect their genetic origin. Some of these clinicians and breeders have access to necessary scientific expertise and sophisticated genetic testing through their home or local institutions. However, many of them have no such access and the identification of genetic disorders is either greatly delayed or does not occur. The objective of this proposal is to promote collaboration within the canine scientific community by pairing the resources of the VGL with researchers and veterinarians who have identified normal or abnormal canine traits of a possible genetic nature, but who lack the scientific or laboratory expertise to confirm their findings. The VGL has extensive experience in animal genetic testing, the technical infrastructure to perform large scale genotyping, and now has a genome screening set optimized for efficient linkage analysis. The VGL proposes to match its strengths with the phenotyping expertise of researchers or veterinarians. Successful collaborations will lead to DNA tests and/or the discovery of causal genes that in turn will improve the health of dogs.


Greer, K. A., Wong, A. K., Liu, H., Famula, T. R., Pedersen, N. C., Ruhe, A., … Neff, M. W. (2010). Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens. https://doi.org/10.1111/j.1399-0039.2010.01484.x

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