01063-A: Knee Kinematics, Kinetics and Neuromuscular Patterns in Labrador Retrievers at Low Risk to Cranial Cruciate Disease

Grant Status: Closed

Grant Amount: $12,960
Dr. Dominique J. Griffon, DVM PhD, University of Illinois
August 1, 2008 - January 31, 2010
Breed(s): Labrador Retriever
Research Program Area: Prevention

Project Summary

Dual energy X-ray absorptiometry (DEXA), radiographs of the rear limbs under sedation and gait analysis of adult Labrador Retrievers was performed to document mechanical characteristics of the canine gait that may explain predisposition to cranial cruciate ligament (CCL) disease. Repartition between non-predisposed or predisposed to CCL disease group is based on the femoral anterversion angle and the tibial plateau slope measured on radiographs. Twenty-three Labrador Retrievers, between 12 and 130 month-old were recruited. Unfortunately, canine hip dysplasia was diagnosed on hip radiographs in two dogs which were excluded from the study and one dog was not able to completely perform the gait analysis section. Therefore, the gait analysis data were collected in twenty trotting dogs over ground and over a treadmill. The large quantity of data is still being analyzed to compare the mechanical characteristics of the canine gait between dogs pre-disposed to CCL and controls.

Publication(s)

Mostafa, A.A., Griffon, D.J., Thomas, M.W., Constable, P.D., 2010, Morphometric Characteristics of the Pelvic Limb Musculature of Labrador Retrievers with and without Cranial Cruciate Ligament Deficiency. Veterinary Surgery 39, 380-389. Griffon, D.J., 2010, A Review of the Pathogenesis of Canine Cranial Cruciate Ligament Disease as a Basis for Future Preventive Strategies. Veterinary Surgery 39, 399-409. Ragetly, C.A., Griffon, D.J., Mostafa, A.A., Thomas, J.E., Hsiao-Wecksler, E.T., 2010, Inverse Dynamics Analysis of the Pelvic Limbs in Labrador Retrievers With and Without Cranial Cruciate Ligament Disease. Veterinary Surgery 39, 513-522. Unis, M.D., Johnson, A.L., Griffon, D.J., Schaeffer, D.J., Ragetly, G.R., Hoffer, M.J., Ragetly, C.A., 2010, Evaluation of Intra- and Interobserver Variability and Repeatability of Tibial Plateau Angle Measurements with Digital Radiography Using a Novel Digital Radiographic Program. Veterinary Surgery 39, 187-194.

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