Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 2219 Research Program Area: Gastrointestinal Disease |
Longitudinal Clinical Study, Mode of Inheritance and Therapeutic Trial of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers Allenspach, K., Vaden, S. L., Harris, T. S., Gröne, A., Doherr, M. G., Griot-Wenk, M. E., … Gaschen, F. (2006). Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions. Journal of Small Animal Practice, 47(1), 21–26. https://doi.org/10.1111/j.1748-5827.2006.00007.x
Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027 |
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Grant Number: 1285 Research Program Area: Gastrointestinal Disease |
Mode of Inheritance and Method for Early Detection of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027 |
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Grant Number: 01317 Research Program Area: Oncology - Osteosarcoma |
Mutation Detection and Functional Analysis of Multiple Loci for Osteosarcoma Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
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Grant Number: 0002254B Research Program Area: Oncology |
Heritable and Sporadic Genetic Lesions in Canine Lymphoma and Osteosarcoma Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., … Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Veterinary Pathology, 42(5), 618–632. https://doi.org/10.1354/vp.42-5-618
Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467
Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … Modiano, J. F. (2013). Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma. Veterinary Pathology, 50(4), 693–703. https://doi.org/10.1177/0300985812465325
Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., Fosmire, S. P., Coffey, D., … Modiano, J. F. (2005). CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Veterinary Pathology, 42(4), 468–476. https://doi.org/10.1354/vp.42-4-468
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613
Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A.-M., Hogendoorn, P. C., Modiano, J. F., & Subramanian, S. (2013). MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. Orphanet Journal of Rare Diseases, 8(1), 7. https://doi.org/10.1186/1750-1172-8-7
Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., … Modiano, J. F. (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone, 49(3), 356–367. https://doi.org/10.1016/j.bone.2011.05.008
Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., … Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619
Thayanithy, V., Park, C., Sarver, A. L., Kartha, R. V., Korpela, D. M., Graef, A. J., … Subramanian, S. (2012). Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines. PLoS ONE, 7(9), e43720. https://doi.org/10.1371/journal.pone.0043720
Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., … Subramanian, S. (2012). Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. Bone, 50(1), 171–181. https://doi.org/10.1016/j.bone.2011.10.012
Thomas, R., Wang, H. J., Tsai, P.-C., Langford, C. F., Fosmire, S. P., Jubala, C. M., … Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research, 17(3), 365–377. https://doi.org/10.1007/s10577-009-9028-z |
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Grant Number: 0276 Research Program Area: Cardiology |
Microarray Analysis for Cardiac Gene Expression in German Shepherd Dogs with Sudden Death Cruickshank, J., Quaas, R. L., Li, J., Hemsley, S., Gunn, T. M., & Moïse, N. S. (2009). Genetic Analysis of Ventricular Arrhythmia in Young German Shepherd Dogs. Journal of Veterinary Internal Medicine, 23(2), 264–270. https://doi.org/10.1111/j.1939-1676.2009.0265.x
Jesty, S. A., Jung, S. W., Cordeiro, J. M., Gunn, T. M., Di Diego, J. M., Hemsley, S., … Moïse, N. S. (2013). Cardiomyocyte calcium cycling in a naturally occurring German Shepherd Dog model of inherited ventricular arrhythmia and sudden cardiac death. Journal of Veterinary Cardiology, 15(1), 5–14. https://doi.org/10.1016/j.jvc.2012.07.005
Liu, W., Hackett, S. R., Cruickshank, J., Vikstrom, K. L., Moise, N. S., & Gunn, T. M. (2006). Canine microsatellites associated with genes implicated in cardiac development and function. Animal Genetics, 37(1), 87–88. https://doi.org/10.1111/j.1365-2052.2005.01410.x
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Grant Number: 01190-A Research Program Area: Neurology |
Frequency of the Exercise-Induced Collapse Gene in Diverse Breeds Furrow, E., Minor, K. M., Taylor, S. M., Mickelson, J. R., & Patterson, E. E. (2013). Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. Journal of the American Veterinary Medical Association, 242(6), 786–791. https://doi.org/10.2460/javma.242.6.786
Minor, K. M., Patterson, E. E., Keating, M. K., Gross, S. D., Ekenstedt, K. J., Taylor, S. M., & Mickelson, J. R. (2011). Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador Retrievers and other breeds. The Veterinary Journal, 189(2), 214–219. https://doi.org/10.1016/j.tvjl.2011.06.022
Patterson, E. E., Minor, K. M., Tchernatynskaia, A. V., Taylor, S. M., Shelton, G. D., Ekenstedt, K. J., & Mickelson, J. R. (2008). A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nature Genetics, 40(10), 1235–1239. https://doi.org/10.1038/ng.224 |
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Grant Number: 0002254A Research Program Area: Oncology |
Heritable and Sporadic Genetic Lesions in Canine Lymphoma and Osteosarcoma Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., … Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Veterinary Pathology, 42(5), 618–632. https://doi.org/10.1354/vp.42-5-618 Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467 Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … Modiano, J. F. (2013). Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma. Veterinary Pathology, 50(4), 693–703. https://doi.org/10.1177/0300985812465325 Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., Fosmire, S. P., Coffey, D., … Modiano, J. F. (2005). CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Veterinary Pathology, 42(4), 468–476. https://doi.org/10.1354/vp.42-4-468 Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132 Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613 Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A.-M., Hogendoorn, P. C., Modiano, J. F., & Subramanian, S. (2013). MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. Orphanet Journal of Rare Diseases, 8(1), 7. https://doi.org/10.1186/1750-1172-8-7 Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., … Modiano, J. F. (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone, 49(3), 356–367. https://doi.org/10.1016/j.bone.2011.05.008 Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., … Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619 Thayanithy, V., Park, C., Sarver, A. L., Kartha, R. V., Korpela, D. M., Graef, A. J., … Subramanian, S. (2012). Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines. PLoS ONE, 7(9), e43720. https://doi.org/10.1371/journal.pone.0043720 Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., … Subramanian, S. (2012). Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. Bone, 50(1), 171–181. https://doi.org/10.1016/j.bone.2011.10.012 Thomas, R., Wang, H. J., Tsai, P.-C., Langford, C. F., Fosmire, S. P., Jubala, C. M., … Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research, 17(3), 365–377. https://doi.org/10.1007/s10577-009-9028-z |
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Grant Number: 1485 Research Program Area: Gastrointestinal Disease |
Study of PLE/PLN (Protein-losing Enteropathy/Nephropathy) in Soft-Coated Wheaten Terriers Littman, M. P., Wiley, C. A., Raducha, M. G., & Henthorn, P. S. (2013). Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mammalian Genome, 24(3–4), 119–126. https://doi.org/10.1007/s00335-012-9445-8
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Grant Number: 00779 Research Program Area: Reproductive Conditions |
Characterization of the Canine Y Chromosome: Identifying Genes that Cause Male Infertility Li, G., Davis, B. W., Raudsepp, T., Pearks Wilkerson, A. J., Mason, V. C., Ferguson-Smith, M., … Murphy, W. J. (2013). Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution. Genome Research, 23(9), 1486–1495. https://doi.org/10.1101/gr.154286.112 |
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Grant Number: 00903-A Research Program Area: Ophthalmology |
Candidate Gene Investigation of Cairn Terrier Ocular Melanosis Winkler, P. A., Bartoe, J. T., Quinones, C. R., Venta, P. J., & Petersen-Jones, S. M. (2013). Exclusion of eleven candidate genes for ocular melanosis in Cairn Terriers. Journal of Negative Results in BioMedicine, 12(1). https://doi.org/10.1186/1477-5751-12-6 |
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Grant Number: 00369-A Research Program Area: Reproductive Conditions |
Analysis of the Ultrastructure of the Canine Zona Pellucida Lunn, M. O., & Wright, S. J. (2009). Imaging the Zona Pellucida of Canine and Feline Oocytes Using Scanning Electron Microscopy. Microscopy and Microanalysis, 15(01), 2–14. https://doi.org/10.1017/S1431927609090084
Lunn, M. O., & Wright, S. J. (2013). Distinct subtypes of zona pellucida morphology reflect canine oocyte viability and cumulus-oocyte complex quality. Theriogenology, 80(5), 498–506. https://doi.org/10.1016/j.theriogenology.2013.05.013
Lunn, M., & Wright, S. (2006). Analysis of the Ultrastructure of the Canine Zona Pellucida. Microscopy and Microanalysis, 12(S02), 270–271. https://doi.org/10.1017/S1431927606066281 |
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Grant Number: 02131 Research Program Area: Epilepsy Initiative |
Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy Milne, M. E., Anderson, G. A., Chow, K. E., O’Brien, T. J., Moffat, B. A., & Long, S. N. (2013). Description of technique and lower reference limit for magnetic resonance imaging of hippocampal volumetry in dogs. American Journal of Veterinary Research, 74(2), 224–231. https://doi.org/10.2460/ajvr.74.2.224 Milne, M. E., Steward, C., Firestone, S. M., Long, S. N., O’Brien, T. J., & Moffat, B. A. (2016). Development of representative magnetic resonance imaging–based atlases of the canine brain and evaluation of three methods for atlas-based segmentation. American Journal of Veterinary Research, 77(4), 395–403. https://doi.org/10.2460/ajvr.77.4.395 |
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Grant Number: 1601 Research Program Area: Hepatic Disease |
Identifying the Genetic Cause of Fatal Neonatal Liver Disease van Steenbeek, F. G., Spee, B., Penning, L. C., Kummeling, A., van Gils, I. H. M., Grinwis, G. C. M., … Leegwater, P. A. J. (2013). Altered Subcellular Localization of Heat Shock Protein 90 Is Associated with Impaired Expression of the Aryl Hydrocarbon Receptor Pathway in Dogs. PLoS ONE, 8(3), e57973. https://doi.org/10.1371/journal.pone.0057973
van Steenbeek, F. G., Van den Bossche, L., Grinwis, G. C. M., Kummeling, A., van Gils, I. H. M., Koerkamp, M. J. A. Groot., … Spee, B. (2013). Aberrant Gene Expression in Dogs with Portosystemic Shunts. PLoS ONE, 8(2), e57662. https://doi.org/10.1371/journal.pone.0057662
van Steenbeek, F. G., van den Bossche, L., Leegwater, P. A. J., & Rothuizen, J. (2012). Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein. Mammalian Genome, 23(1–2), 76–84. https://doi.org/10.1007/s00335-011-9364-0 |
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Grant Number: 760 Research Program Area: Oncology |
Cellular Genomics - Molecular Cytogenetic Investigation of Canine Soft Tissue Sarcomas Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-201
Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Ostrander, E. A. (2012). The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer. Cancer Epidemiology Biomarkers & Prevention, 21(7), 1019–1027. https://doi.org/10.1158/1055-9965.EPI-12-0190-T
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Grant Number: 1280 Research Program Area: Epilepsy Initiative |
Bromide as Sole Drug Therapy for Treatment of Canine Epilepsy Boothe, D. M., Dewey, C., & Carpenter, D. M. (2012). Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs. Journal of the American Veterinary Medical Association, 240(9), 1073–1083. https://doi.org/10.2460/javma.240.9.1073 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
