Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01876-A Research Program Area: Oncology |
Ensuring That Emerging Stem Cell Treatments Do Not Activate or Exacerbate Cancer in Dogs Volk, S. W., & Theoret, C. (2013). Translating stem cell therapies: The role of companion animals in regenerative medicine: Stem cell therapies in veterinary medicine. Wound Repair and Regeneration, 21(3), 382–394. https://doi.org/10.1111/wrr.12044 |
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Grant Number: 01194-A Research Program Area: Oncology |
Role of Hypoxia-Related Factors in Dog Glioblastoma Invasion Stoica, G., Levine, J., Wolff, J., & Murphy, K. (2011). Canine Astrocytic Tumors: A Comparative Review. Veterinary Pathology, 48(1), 266–275. https://doi.org/10.1177/0300985810389543
Stoica, G., Lungu, G., Martini-STOICA, H., Waghela, S., Levine, J., & Smith, R. (2009). Identification of Cancer Stem Cells in Dog Glioblastoma. Veterinary Pathology, 46(3), 391–406. https://doi.org/10.1354/vp.08-VP-0218-S-FL |
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Grant Number: 00757A Research Program Area: Oncology - Osteosarcoma |
Hereditary Mutations in Genes Associated with Osteosarcoma in Large Dog Breeds Karlsson, E. K., Baranowska, I., Wade, C. M., Salmon Hillbertz, N. H. C., Zody, M. C., Anderson, N., … Lindblad-Toh, K. (2007). Efficient mapping of mendelian traits in dogs through genome-wide association. Nature Genetics, 39(11), 1321–1328. https://doi.org/10.1038/ng.2007.10
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
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Grant Number: 00768 Research Program Area: Oncology - Lymphoma |
A Collaborative Study by Veterinary Oncologists, Pathologists and Diagnostic Laboratories to Enhance the Detection, Diagnosis and Treatment of Canine Lymphoma Valli, V. E., Kass, P. H., Myint, M. S., & Scott, F. (2013). Canine Lymphomas: Association of Classification Type, Disease Stage, Tumor Subtype, Mitotic Rate, and Treatment With Survival. Veterinary Pathology, 50(5), 738–748. https://doi.org/10.1177/0300985813478210 Valli, V. E., Myint, M. S., Barthel, A., Bienzle, D., Caswell, J., Colbatzky, F., … Vernau, W. (2011). Classification of Canine Malignant Lymphomas According to the World Health Organization Criteria. Veterinary Pathology, 48(1), 198–211. https://doi.org/10.1177/0300985810379428 |
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Grant Number: 00373A Research Program Area: Oncology - Osteosarcoma |
Mapping Genes Associated with Osteosarcoma in Large Dog Breeds Karlsson, E. K., Baranowska, I., Wade, C. M., Salmon Hillbertz, N. H. C., Zody, M. C., Anderson, N., … Lindblad-Toh, K. (2007). Efficient mapping of mendelian traits in dogs through genome-wide association. Nature Genetics, 39(11), 1321–1328. https://doi.org/10.1038/ng.2007.10 Karlsson, E. K., & Lindblad-Toh, K. (2008). Leader of the pack: Gene mapping in dogs and other model organisms. Nature Reviews Genetics, 9(9), 713–725.https://doi.org/10.1038/nrg2382 Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132 Salmon Hillbertz, N. H. C., Isaksson, M., Karlsson, E. K., Hellmén, E., Pielberg, G. R., Savolainen, P., … Andersson, G. (2007). Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback Dogs. Nature Genetics, 39(11), 1318–1320.https://doi.org/10.1038/ng.2007.4 |
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Grant Number: 00978-A Research Program Area: Oncology |
Isolation of the Canine Telomerase Reverse Transcriptase (TERT) Subunit and Generation of Dominant-Negative Mutants for Telomerase Inhibition Milne, M. E., Anderson, G. A., Chow, K. E., O’Brien, T. J., Moffat, B. A., & Long, S. N. (2013). Description of technique and lower reference limit for magnetic resonance imaging of hippocampal volumetry in dogs. American Journal of Veterinary Research, 74(2), 224–231. https://doi.org/10.2460/ajvr.74.2.224 |
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Grant Number: 01535-A Research Program Area: Kidney & Urological Disease |
DNA Sequence Examination of a Gene Region Associated with Mastiff Cystine Stone Formation Brons, A.-K., Henthorn, P. S., Raj, K., Fitzgerald, C. A., Liu, J., Sewell, A. C., & Giger, U. (2013). SLC3A1 and SLC7A9 Mutations in Autosomal Recessive or Dominant Canine Cystinuria: A New Classification System. Journal of Veterinary Internal Medicine, 27(6), 1400–1408. https://doi.org/10.1111/jvim.12176
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Grant Number: 01497-A Research Program Area: Oncology - Lymphoma |
Dog leukocyte antigen 88 typing in German Shepherd Dogs having pancreatic insufficiency Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y |
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Grant Number: 01052-A Research Program Area: Oncology |
Whole Genome Association Mapping of Squamous Cell Carcinoma (SCC) of the Digit in the Standard Poodle Karyadi, D. M., Karlins, E., Decker, B., vonHoldt, B. M., Carpintero-Ramirez, G., Parker, H. G., … Ostrander, E. A. (2013). A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit. PLoS Genetics, 9(3), e1003409. https://doi.org/10.1371/journal.pgen.1003409 |
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Grant Number: 934 Research Program Area: Neurology |
Investigation of Inherited Diseases of the German Shepherd Dog Using the SNP Array Tsai, K. L., Noorai, R. E., Starr-Moss, A. N., Quignon, P., Rinz, C. J., Ostrander, E. A., … Clark, L. A. (2012). Genome-wide association studies for multiple diseases of the German Shepherd Dog. Mammalian Genome, 23(1–2), 203–211. https://doi.org/10.1007/s00335-011-9376-9
Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y
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Grant Number: 00947A Research Program Area: Oncology |
Heritable and Sporadic Genetic Lesions in Canine Osteosarcoma Angstadt, A. Y., Motsinger-Reif, A., Thomas, R., Kisseberth, W. C., Guillermo Couto, C., Duval, D. L., … Breen, M. (2011). Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: Signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart. Genes, Chromosomes and Cancer, 50(11), 859–874. https://doi.org/10.1002/gcc.20908
Angstadt, A. Y., Thayanithy, V., Subramanian, S., Modiano, J. F., & Breen, M. (2012). A genome-wide approach to comparative oncology: High-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. Cancer Genetics, 205(11), 572–587. https://doi.org/10.1016/j.cancergen.2012.09.005
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A.-M., Hogendoorn, P. C., Modiano, J. F., & Subramanian, S. (2013). MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. Orphanet Journal of Rare Diseases, 8(1), 7. https://doi.org/10.1186/1750-1172-8-7
Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., … Modiano, J. F. (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone, 49(3), 356–367. https://doi.org/10.1016/j.bone.2011.05.008 |
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Grant Number: 00613 Research Program Area: Oncology - Lymphoma |
The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma Seiser, E. L., Thomas, R., Richards, K. L., Kathryn Kelley, M., Moore, P., Suter, S. E., & Breen, M. (2013). Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines. Veterinary and Comparative Oncology, 11(1), 30–50. https://doi.org/10.1111/j.1476-5829.2011.00299.x Thomas, R., Seiser, E. L., Motsinger-Reif, A., Borst, L., Valli, V. E., Kelley, K., … Breen, M. (2011). Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leukemia & Lymphoma, 52(7), 1321–1335. https://doi.org/10.3109/10428194.2011.559802 |
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Grant Number: 01531-A Research Program Area: Immunology and Infectious Disease |
Potential Role of Pericytes in Bartonella-induced Vasoproliferation Varanat, M., Maggi, R. G., Linder, K. E., & Breitschwerdt, E. B. (2013). Infection of human brain vascular pericytes (HBVPs) by Bartonella henselae. Medical Microbiology and Immunology, 202(2), 143–151. https://doi.org/10.1007/s00430-012-0279-5 |
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Grant Number: 00970 Research Program Area: General Canine Health |
Tissue Regeneration Using Canine Mesenchymal Stem Cells: Effects of Donor Characteristics and ex vivo Expansion on Cell Pluripotency Volk, S. W., & Theoret, C. (2013). Translating stem cell therapies: The role of companion animals in regenerative medicine. Wound Repair and Regeneration, 21(3), 382–394. https://doi.org/10.1111/wrr.12044 Volk, S. W., Wang, Y., & Hankenson, K. D. (2012). Effects of Donor Characteristics and Ex Vivo Expansion on Canine Mesenchymal Stem Cell Properties: Implications for MSC-Based Therapies. Cell Transplantation, 21(10), 2189–2200. https://doi.org/10.3727/096368912X636821 |
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Grant Number: 1272 Research Program Area: General Canine Health |
Isolation and Characterization of Canine Induced Pluripotential Stem Cells (iPS)
Koh, S., Thomas, R., Tsai, S., Bischoff, S., Lim, J.-H., Breen, M., … Piedrahita, J. A. (2013). Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts. Stem Cells and Development, 22(6), 951–963. https://doi.org/10.1089/scd.2012.0393 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
