Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01698-A Research Program Area: Oncology |
Immunohistochemical quantification of the transcobalamin II protein and receptor in naturally occurring canine tumors. Sysel, A. M., Valli, V. E., & Bauer, J. A. (2015). Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues. Oncotarget, 6(4), 2331–2348. https://doi.org/10.18632/oncotarget.3206 |
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Grant Number: 00294-A Research Program Area: Musculoskeletal Conditions and Disease |
Enhancement of Current Background Information and DNA Material Necessary for the Future Development of a Molecular Genetics Study in Collies and Shetland Sheepdogs with Dermatomyositis Clark, L. A., Credille, K. M., Murphy, K. E., & Rees, C. A. (2005). Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35. Veterinary Dermatology, 16(6), 392–394. https://doi.org/10.1111/j.1365-3164.2005.00469.x
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Grant Number: 01683-A Research Program Area: Oncology |
Improving Resection of Tumors through Enhanced Imaging Holt, D., Parthasarathy, A. B., Okusanya, O., Keating, J., Venegas, O., Deshpande, C., … Singhal, S. (2015). Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds. Journal of Biomedical Optics, 20(7), 076002. https://doi.org/10.1117/1.JBO.20.7.076002 Madajewski, B., Judy, B. F., Mouchli, A., Kapoor, V., Holt, D., Wang, M. D., … Singhal, S. (2012). Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease. Clinical Cancer Research, 18(20), 5741–5751. https://doi.org/10.1158/1078-0432.CCR-12-1188 |
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Grant Number: 01674-A Research Program Area: Endocrinology |
Molecular Basis of Congenital Hypothyroidism with Goiter in Spanish Water Dogs Fyfe, J. C., Lynch, M., Olsen, J., & Lou?r, E. (2013). A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure. Mammalian Genome, 24(3–4), 127–133. https://doi.org/10.1007/s00335-012-9442-y
Major, S., Pettigrew, R. W., & Fyfe, J. C. (2015). Molecular Genetic Characterization of Thyroid Dyshormonogenesis in a French Bulldog. Journal of Veterinary Internal Medicine, 29(6), 1534–1540. https://doi.org/10.1111/jvim.13651 |
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Grant Number: 01362-A Research Program Area: Neurology |
Investigation of the Genetics of Scottie Cramp: DNA Sample Collection Urkasemsin, G., & Olby, N. J. (2015). Clinical characteristics of Scottie Cramp in 31 cases. Journal of Small Animal Practice, 56(4), 276–280. https://doi.org/10.1111/jsap.12317 |
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Grant Number: 01684-A Research Program Area: Endocrinology |
Improved Method for Early Diagnosis of Atypical Cushing's Disease Frank, L. A., Henry, G. A., Whittemore, J. C., Enders, B. D., Mawby, D. I., & Rohrbach, B. W. (2015). Serum Cortisol Concentrations in Dogs with Pituitary-Dependent Hyperadrenocorticism and Atypical Hyperadrenocorticism. Journal of Veterinary Internal Medicine, 29(1), 193–199. https://doi.org/10.1111/jvim.12500 |
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Grant Number: 01949-A Research Program Area: Oncology - Osteosarcoma |
Targeting the Cell's Activation Machinery to Halt Tumor Metastasis in Canine Osteosarcoma Marley, K., Bracha, S., & Seguin, B. (2015). Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL. Experimental Cell Research, 338(1), 32–38. https://doi.org/10.1016/j.yexcr.2015.08.001
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Grant Number: 01169-A Research Program Area: Oncology - Hemangiosarcoma |
Identifying Mutations in Genes Associated with Canine Hemangiosarcoma: Denser Fine Mapping of the Associated Locus in Chromosome 26 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
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Grant Number: 1424 Research Program Area: Musculoskeletal Conditions and Disease |
Genetic Analysis of Cleft Palate/Lip Wolf, Z. T., Brand, H. A., Shaffer, J. R., Leslie, E. J., Arzi, B., Willet, C. E., … Bannasch, D. L. (2015). Genome-Wide Association Studies in Dogs and Humans Identify ADAMTS20 as a Risk Variant for Cleft Lip and Palate. PLOS Genetics, 11(3), e1005059. https://doi.org/10.1371/journal.pgen.1005059
Wolf, Z. T., Leslie, E. J., Arzi, B., Jayashankar, K., Karmi, N., Jia, Z., … Bannasch, D. L. (2014). A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. PLoS Genetics, 10(4), e1004257. https://doi.org/10.1371/journal.pgen.1004257
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Grant Number: 1612 Research Program Area: Ophthalmology |
Regulation of Inflammation to Prevent Cataract Surgery Complications Chandler, H. L., Gervais, K. J., Lutz, E. A., Curto, E. M., Matusow, R. B., Wilkie, D. A., & Gemensky-Metzler, A. J. (2015). Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death. Experimental Eye Research, 134, 63–72. https://doi.org/10.1016/j.exer.2015.03.020 |
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Grant Number: 01854-A Research Program Area: Behavior |
Identifying the Cause of Canine Compulsive Disorder Hall, N. J., Protopopova, A., & Wynne, C. D. L. (2015). The role of environmental and owner-provided consequences in canine stereotypy and compulsive behavior. Journal of Veterinary Behavior, 10(1), 24–35. https://doi.org/10.1016/j.jveb.2014.10.005
Protopopova, A., Hall, N. J., & Wynne, C. D. L. (2014). Association between increased behavioral persistence and stereotypy in the pet dog. Behavioural Processes, 106, 77–81. https://doi.org/10.1016/j.beproc.2014.04.009 |
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Grant Number: 1594 Research Program Area: Ophthalmology |
Identifying the Genes Associated with Glaucoma Ahram, D. F., Cook, A. C., Kecova, H., Grozdanic, S. D., & Kuehn, M. H. (2014). Identification of genetic loci associated with primary angle-closure. Molecular Vision, 14.
Ahram, D. F., Grozdanic, S. D., Kecova, H., Henkes, A., Collin, R. W. J., & Kuehn, M. H. (2015). Variants in Nebulin (NEB) Are Linked to the Development of Familial Primary Angle Closure Glaucoma in Basset Hounds. PLOS ONE, 10(5), e0126660. https://doi.org/10.1371/journal.pone.0126660 |
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Grant Number: 01524-A Research Program Area: Oncology - Lymphoma |
Leukocyte Oxidative Burst Activity in Peripheral Blood of Dogs with Lymphoma Axiak-Bechtel, S., Fowler, B., Yu, D. H., Amorim, J., Tsuruta, K., & DeClue, A. (2014). Chemotherapy and remission status do not alter pre-existing innate immune dysfunction in dogs with lymphoma. Research in Veterinary Science, 97(2), 230–237. https://doi.org/10.1016/j.rvsc.2014.07.009 Axiak-Bechtel, S. M., Tsuruta, K., Amorim, J., Donaldson, R., Lino, G., Honaker, A., … DeClue, A. (2015). Effects of tramadol and o-desmethyltramadol on canine innate immune system function. Veterinary Anaesthesia and Analgesia, 42(3), 260–268. https://doi.org/10.1111/vaa.12201 |
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Grant Number: 02111-A Research Program Area: Dermatology and Allergic Disease |
Evaluating the Contribution of Fungal Infection to the Pathogenesis of Atopic Dermatitis: Putting Evidence under the Use of Antifungal Medication
Meason-Smith, C., Diesel, A., Patterson, A. P., Older, C. E., Mansell, J. M., Suchodolski, J. S., & Rodrigues Hoffmann, A. (2015). What is living on your dog’s skin? Characterization of the canine cutaneous mycobiota and fungal dysbiosis in canine allergic dermatitis. FEMS Microbiology Ecology, 91(12), fiv139. https://doi.org/10.1093/femsec/fiv139 |
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Grant Number: 01147 Research Program Area: Oncology - Hemangiosarcoma |
Identifying Mutations in Genes Associated with Canine Hemangiosarcoma >Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
