Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02123-A Research Program Area: Reproductive Conditions |
Identifying the Gene Responsible For Inherited Infertility and Sterility in 28 Breeds Meyers-Wallen, V. N., Boyko, A. R., Danko, C. G., Grenier, J. K., Mezey, J. G., Hayward, J. J., … Sinclair, A. H. (2017). XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris). PLOS ONE, 12(10), e0186331. https://doi.org/10.1371/journal.pone.0186331 |
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Grant Number: 01995 Research Program Area: Behavior |
Understanding the Flexibility and Limitations of How Dogs Acquire Knowledge and Understanding: Application to Service Dog Emotional Health and Selection Bray, E. E., MacLean, E. L., & Hare, B. A. (2015). Increasing arousal enhances inhibitory control in calm but not excitable dogs. Animal Cognition, 18(6), 1317–1329. https://doi.org/10.1007/s10071-015-0901-1 MacLean, E. L., & Hare, B. (2018). Enhanced Selection of Assistance and Explosive Detection Dogs Using Cognitive Measures. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00236 MacLean, E. L., Herrmann, E., Suchindran, S., & Hare, B. (2017). Individual differences in cooperative communicative skills are more similar between dogs and humans than chimpanzees. Animal Behaviour, 126, 41–51. https://doi.org/10.1016/j.anbehav.2017.01.005 |
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Grant Number: 01900-A Research Program Area: Immunology and Infectious Disease, Tick-Borne Disease Initiative |
Prevalence of Vector Borne Disease in Dogs with Clinical Signs of Immune Mediated Disease Kidd, L., Qurollo, B., Lappin, M., Richter, K., Hart, J. R., Hill, S., … Breitschwerdt, E. B. (2017). Prevalence of Vector-Borne Pathogens in Southern California Dogs With Clinical and Laboratory Abnormalities Consistent With Immune-Mediated Disease. Journal of Veterinary Internal Medicine, 31(4), 1081–1090. https://doi.org/10.1111/jvim.14735 |
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Grant Number: 00652-A Research Program Area: Immunology and Infectious Disease |
A New Bartonella Infection in Domestic Dogs from Northern California Harms, A., Segers, F. H. I. D., Quebatte, M., Mistl, C., Manfredi, P., Körner, J., … Dehio, C. (2017). Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella. Genome Biology and Evolution, 9(3), 761–776. https://doi.org/10.1093/gbe/evx042
Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Koehler, J. E., MacDonald, K. A., … Chomel, B. B. (2009). Infective Endocarditis in a Dog and the Phylogenetic Relationship of the Associated “Bartonella rochalimae” Strain with Isolates from Dogs, Gray Foxes, and a Human. Journal of Clinical Microbiology, 47(3), 787–790. https://doi.org/10.1128/JCM.01351-08
Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Theis, J. H., Foley, J. E., & Chomel, B. B. (2007). Gray Foxes (Urocyon cinereoargenteus) as a Potential Reservoir of a Bartonella clarridgeiae-Like Bacterium and Domestic Dogs as Part of a Sentinel System for Surveillance of Zoonotic Arthropod-Borne Pathogens in Northern California. Journal of Clinical Microbiology, 45(8), 2411–2418. https://doi.org/10.1128/JCM.02539-06
Henn, Jennifer B., Chomel, B. B., Boulouis, H.-J., Kasten, R. W., Murray, W. J., Bar-Gal, G. K., … Baneth, G. (2009). Bartonella rochalimae in Raccoons, Coyotes, and Red Foxes. Emerging Infectious Diseases, 15(12), 1984–1987. https://doi.org/10.3201/eid1512.081692 |
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Grant Number: 02238-A Research Program Area: Blood Disorders |
Effect of Platelet Count on Platelet Function Tests in Dogs Nash, K. J., Bacek, L. M., Christopherson, P. W., & Spangler, E. A. (2017). In vitro effect of blood cell counts on multiple-electrode impedance aggregometry in dogs. American Journal of Veterinary Research, 78(12), 1380–1386. https://doi.org/10.2460/ajvr.78.12.1380 |
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Grant Number: 01894-A Research Program Area: Immunology and Infectious Disease, Tick-Borne Disease Initiative |
Documentation of Disease-Causing Ticks in a Field Trial Environment for the Purpose of Developing Practical and Cost-Effective Strategies for Tick Control Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016a). Comparison of novel and conventional methods of trapping ixodid ticks in the southeastern U.S.A. Medical and Veterinary Entomology, 30(2), 123–134. https://doi.org/10.1111/mve.12160
Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016b). Specifying Pathogen Associations of Amblyomma maculatum (Acari: Ixodidae) in Western Tennessee. Journal of Medical Entomology, 53(2), 435–440. https://doi.org/10.1093/jme/tjv238
Mays, Sarah E, Hendricks, B. M., Paulsen, D. J., Houston, A. E., & Fryxell, R. T. T. (2014). Prevalence of five tick-borne bacterial genera in adult Ixodes scapularis removed from white-tailed deer in western Tennessee. Parasites and Vectors, 7, 473.
Trout Fryxell, R. T., Moore, J. E., Collins, M. D., Kwon, Y., Jean-Philippe, S. R., Schaeffer, S. M., … Houston, A. E. (2015). Habitat and Vegetation Variables Are Not Enough When Predicting Tick Populations in the Southeastern United States. PLOS ONE, 10(12), e0144092. https://doi.org/10.1371/journal.pone.0144092
Trout Fryxell, Rebecca T., Hendricks, B. M., Pompo, K., Mays, S. E., Paulsen, D. J., Operario, D. J., & Houston, A. E. (2017). Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma , Ehrlichia , and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. Vector-Borne and Zoonotic Diseases, 17(8), 527–538. https://doi.org/10.1089/vbz.2016.2091 |
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Grant Number: 01188-A Research Program Area: Lung and Respiratory Disease |
Capacity for Respiratory-Based Thermoregulation in Brachycephalic Breeds Davis, M. S., Cummings, S. L., & Payton, M. E. (2017). Effect of brachycephaly and body condition score on respiratory thermoregulation of healthy dogs. Journal of the American Veterinary Medical Association, 251(10), 1160–1165. https://doi.org/10.2460/javma.251.10.1160 |
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Grant Number: 02142-A Research Program Area: Musculoskeletal Conditions and Disease |
Development of Magnetic Resonance Imaging as a Non-Invasive Tool to Accurately Evaluate Elbow Dysplasia Franklin, S. P., Burke, E. E., & Holmes, S. P. (2017). Utility of MRI for Characterizing Articular Cartilage Pathology in Dogs with Medial Coronoid Process Disease. Frontiers in Veterinary Science, 4. https://doi.org/10.3389/fvets.2017.00025 |
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Grant Number: 01893-A Research Program Area: Musculoskeletal Conditions and Disease |
A Novel, Practical, and Cost-Effective Treatment for Canine Arthritis Sherwood, J. M., Roush, J. K., Armbrust, L. J., & Renberg, W. C. (2017). Prospective Evaluation of Intra-Articular Dextrose Prolotherapy for Treatment of Osteoarthritis in Dogs. Journal of the American Animal Hospital Association, 53(3), 135–142. https://doi.org/10.5326/JAAHA-MS-6508 |
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Grant Number: 927 Research Program Area: Neurology |
Gene Discovery in Hereditary Cerebellar Abiotrophy of Scottish Terriers Urkasemsin, G., Linder, K. E., Bell, J. S., De Lahunta, A., & Olby, N. J. (2010). Hereditary Cerebellar Degeneration in Scottish Terriers. Journal of Veterinary Internal Medicine, 24(3), 565–570. https://doi.org/10.1111/j.1939-1676.2010.0499.x
Urkasemsin, G., Linder, K. E., Bell, J. S., de Lahunta, A., & Olby, N. J. (2012). Mapping of Purkinje Neuron Loss and Polyglucosan Body Accumulation in Hereditary Cerebellar Degeneration in Scottish Terriers. Veterinary Pathology, 49(5), 852–859. https://doi.org/10.1177/0300985811412622
Urkasemsin, G., Nielsen, D. M., Singleton, A., Arepalli, S., Hernandez, D., Agler, C., & Olby, N. J. (2017). Genetics of Hereditary Ataxia in Scottish Terriers. Journal of Veterinary Internal Medicine, 31(4), 1132–1139. https://doi.org/10.1111/jvim.14738 |
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Grant Number: 01866-A Research Program Area: Cardiology |
Enhancing Treatment of Mitral Valve Disease through the Identification of Biological Markers of Disease Winter, R. L., Saunders, A. B., Gordon, S. G., Miller, M. W., Fosgate, G. T., Suchodolski, J. S., & Steiner, J. M. (2017). Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high-sensitivity immunoassays. Veterinary Clinical Pathology, 46(2), 299–307. http://doi.org/10.1111/vcp.12495 Winter, R. L., Saunders, A. B., Gordon, S. G., Buch, J. S., & Miller, M. W. (2017). Winter, R. L., Saunders, A. B., Gordon, S. G., Buch, J. S., & Miller, M. W. (2017). Biologic variability of N-terminal pro-brain natriuretic peptide in healthy dogs and dogs with myxomatous mitral valve disease. Journal of Veterinary Cardiology, 19(2), 124–131. http://doi.org/https://doi.org/10.1016/j.jvc.2016.11.001 |
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Grant Number: 01912-A Research Program Area: Oncology |
Enhancing the Safety and Efficacy of Anti-Cancer Drugs in Dogs Ferguson, D. C., Cheng, Q., & Blanco, J. G. (2015). Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218. Drug Metabolism and Disposition, 43(7), 922–927. https://doi.org/10.1124/dmd.115.064295 Quiñones-Lombraña, A., Cheng, Q., Ferguson, D. C., & Blanco, J. G. (2016). Transcriptional regulation of the canine carbonyl reductase 1 gene ( cbr1 ) by the specificity protein 1 (Sp1). Gene, 592(1), 209–214. https://doi.org/10.1016/j.gene.2016.08.005 |
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Grant Number: 00993-A Research Program Area: Neurology |
Dynactin Mutations in Canine Idiopathic Laryngeal Paralysis Holt, D. E., Brown, D. C., & Henthorn, P. S. (2016). Evaluation of the dynactin 1 gene in Leonbergers and Labrador Retrievers with laryngeal paralysis. American Journal of Veterinary Research, 77(10), 1114–1120. https://doi.org/10.2460/ajvr.77.10.1114 |
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Grant Number: 1718 Research Program Area: Epilepsy Initiative |
Molecular Genetic Basis of Epilepsy in Standard Schnauzers and English Springer Spaniels McConkey, M. J., Valenzano, D. M., Wei, A., Li, T., Thompson, M. S., Mohammed, H. O., … Krotscheck, U. (2016). Effect of the Proximal Abducting Ulnar Osteotomy on Intra-Articular Pressure Distribution and Contact Mechanics of Congruent and Incongruent Canine Elbows Ex Vivo. Veterinary Surgery, 45(3), 347–355. https://doi.org/10.1111/vsu.12456 |
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Grant Number: 01975-A Research Program Area: Neurology |
Development of a Technique to Treat Nerve and Spinal Cord Damage Through Transplantation of Cells That Support the Repair of Damaged Neurons Lim, J.-H., & Olby, N. J. (2016). Generation of pure cultures of autologous Schwann cells by use of biopsy specimens of the dorsal cutaneous branches of the cervical nerves of young adult dogs. American Journal of Veterinary Research, 77(10), 1166–1174. https://doi.org/10.2460/ajvr.77.10.1166 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
