Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02138 Research Program Area: Endocrinology |
Development of Accurate Diagnostic Tests for Canine Hypothyroidism Pijnacker, T., Kooistra, H. S., Vermeulen, C. F., van der Vinne, M., Prins, M., Galac, S., & Mol, J. A. (2018). Use of basal and TRH-stimulated plasma growth hormone concentrations to differentiate between primary hypothyroidism and nonthyroidal illness in dogs. Journal of Veterinary Internal Medicine, 32(4), 1319–1324. https://doi.org/10.1111/jvim.15139 |
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Grant Number: 2011 Research Program Area: Endocrinology |
Identification of Novel Drugs to Halt the Metastasis of Tumors That Cause Cushing's Syndrome Galac, S., Kool, M. M. J., van den Berg, M. F., Mol, J. A., & Kooistra, H. S. (2014). Expression of steroidogenic factor 1 in canine cortisol-secreting adrenocortical tumors and normal adrenals. Domestic Animal Endocrinology, 49, 1–5. https://doi.org/10.1016/j.domaniend.2014.04.002
Galac, Sara. (2016). Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine. Molecular and Cellular Endocrinology, 421, 34–39. https://doi.org/10.1016/j.mce.2015.06.026
Galac, Sara, & Wilson, D. B. (2015). Animal Models of Adrenocortical Tumorigenesis. Endocrinology and Metabolism Clinics of North America, 44(2), 297–310. https://doi.org/10.1016/j.ecl.2015.02.003
Sanders, K., Mol, J. A., Kooistra, H. S., Slob, A., & Galac, S. (2016). New Insights in the Functional Zonation of the Canine Adrenal Cortex. Journal of Veterinary Internal Medicine, 30(3), 741–750. https://doi.org/10.1111/jvim.13946
Sanders, K., Mol, J. A., Slob, A., Kooistra, H. S., & Galac, S. (2018a). Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: In vitro study. Domestic Animal Endocrinology, 63, 23–30. https://doi.org/10.1016/j.domaniend.2017.11.001
Sanders, K., Mol, J. A., Slob, A., Kooistra, H. S., & Galac, S. (2018b). Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: In vitro study. Domestic Animal Endocrinology, 63, 23–30. https://doi.org/10.1016/j.domaniend.2017.11.001
Sanders, R. A., Kurosawa, T. A., & Sist, M. D. (2018). Ambulatory electrocardiographic evaluation of the occurrence of arrhythmias in healthy Salukis. Journal of the American Veterinary Medical Association, 252(8), 966–969. https://doi.org/10.2460/javma.252.8.966 |
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Grant Number: 01826 Research Program Area: Oncology |
A Novel Treatment for Brain Tumors Using a One Medicine Approach Freeman, A. C., Platt, S. R., Holmes, S., Kent, M., Robinson, K., Howerth, E., … Hadjipanayis, C. G. (2018). Convection-enhanced delivery of cetuximab conjugated iron-oxide nanoparticles for treatment of spontaneous canine intracranial gliomas. Journal of Neuro-Oncology, 137(3), 653–663. https://doi.org/10.1007/s11060-018-2764-1 |
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Grant Number: 02315-A Research Program Area: Oncology - Lymphoma |
Discovering Peptide Targets for Development of Adoptive Cell Therapy for Peripheral T-Cell Lymphoma Nemec, P. S., Kapatos, A., Holmes, J. C., & Hess, P. R. (2018). The prevalent Boxer MHC class Ia allotype dog leukocyte antigen (DLA)-88*034:01 preferentially binds nonamer peptides with a defined motif. HLA, 92(6), 403–407. https://doi.org/10.1111/tan.13398
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Grant Number: 01995 Research Program Area: Behavior |
Understanding the Flexibility and Limitations of How Dogs Acquire Knowledge and Understanding: Application to Service Dog Emotional Health and Selection Bray, E. E., MacLean, E. L., & Hare, B. A. (2015). Increasing arousal enhances inhibitory control in calm but not excitable dogs. Animal Cognition, 18(6), 1317–1329. https://doi.org/10.1007/s10071-015-0901-1 MacLean, E. L., & Hare, B. (2018). Enhanced Selection of Assistance and Explosive Detection Dogs Using Cognitive Measures. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00236 MacLean, E. L., Herrmann, E., Suchindran, S., & Hare, B. (2017). Individual differences in cooperative communicative skills are more similar between dogs and humans than chimpanzees. Animal Behaviour, 126, 41–51. https://doi.org/10.1016/j.anbehav.2017.01.005 |
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Grant Number: 01900-A Research Program Area: Immunology and Infectious Disease, Tick-Borne Disease Initiative |
Prevalence of Vector Borne Disease in Dogs with Clinical Signs of Immune Mediated Disease Kidd, L., Qurollo, B., Lappin, M., Richter, K., Hart, J. R., Hill, S., … Breitschwerdt, E. B. (2017). Prevalence of Vector-Borne Pathogens in Southern California Dogs With Clinical and Laboratory Abnormalities Consistent With Immune-Mediated Disease. Journal of Veterinary Internal Medicine, 31(4), 1081–1090. https://doi.org/10.1111/jvim.14735 |
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Grant Number: 00652-A Research Program Area: Immunology and Infectious Disease |
A New Bartonella Infection in Domestic Dogs from Northern California Harms, A., Segers, F. H. I. D., Quebatte, M., Mistl, C., Manfredi, P., Körner, J., … Dehio, C. (2017). Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella. Genome Biology and Evolution, 9(3), 761–776. https://doi.org/10.1093/gbe/evx042
Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Koehler, J. E., MacDonald, K. A., … Chomel, B. B. (2009). Infective Endocarditis in a Dog and the Phylogenetic Relationship of the Associated “Bartonella rochalimae” Strain with Isolates from Dogs, Gray Foxes, and a Human. Journal of Clinical Microbiology, 47(3), 787–790. https://doi.org/10.1128/JCM.01351-08
Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Theis, J. H., Foley, J. E., & Chomel, B. B. (2007). Gray Foxes (Urocyon cinereoargenteus) as a Potential Reservoir of a Bartonella clarridgeiae-Like Bacterium and Domestic Dogs as Part of a Sentinel System for Surveillance of Zoonotic Arthropod-Borne Pathogens in Northern California. Journal of Clinical Microbiology, 45(8), 2411–2418. https://doi.org/10.1128/JCM.02539-06
Henn, Jennifer B., Chomel, B. B., Boulouis, H.-J., Kasten, R. W., Murray, W. J., Bar-Gal, G. K., … Baneth, G. (2009). Bartonella rochalimae in Raccoons, Coyotes, and Red Foxes. Emerging Infectious Diseases, 15(12), 1984–1987. https://doi.org/10.3201/eid1512.081692 |
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Grant Number: 02238-A Research Program Area: Blood Disorders |
Effect of Platelet Count on Platelet Function Tests in Dogs Nash, K. J., Bacek, L. M., Christopherson, P. W., & Spangler, E. A. (2017). In vitro effect of blood cell counts on multiple-electrode impedance aggregometry in dogs. American Journal of Veterinary Research, 78(12), 1380–1386. https://doi.org/10.2460/ajvr.78.12.1380 |
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Grant Number: 01894-A Research Program Area: Immunology and Infectious Disease, Tick-Borne Disease Initiative |
Documentation of Disease-Causing Ticks in a Field Trial Environment for the Purpose of Developing Practical and Cost-Effective Strategies for Tick Control Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016a). Comparison of novel and conventional methods of trapping ixodid ticks in the southeastern U.S.A. Medical and Veterinary Entomology, 30(2), 123–134. https://doi.org/10.1111/mve.12160
Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016b). Specifying Pathogen Associations of Amblyomma maculatum (Acari: Ixodidae) in Western Tennessee. Journal of Medical Entomology, 53(2), 435–440. https://doi.org/10.1093/jme/tjv238
Mays, Sarah E, Hendricks, B. M., Paulsen, D. J., Houston, A. E., & Fryxell, R. T. T. (2014). Prevalence of five tick-borne bacterial genera in adult Ixodes scapularis removed from white-tailed deer in western Tennessee. Parasites and Vectors, 7, 473.
Trout Fryxell, R. T., Moore, J. E., Collins, M. D., Kwon, Y., Jean-Philippe, S. R., Schaeffer, S. M., … Houston, A. E. (2015). Habitat and Vegetation Variables Are Not Enough When Predicting Tick Populations in the Southeastern United States. PLOS ONE, 10(12), e0144092. https://doi.org/10.1371/journal.pone.0144092
Trout Fryxell, Rebecca T., Hendricks, B. M., Pompo, K., Mays, S. E., Paulsen, D. J., Operario, D. J., & Houston, A. E. (2017). Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma , Ehrlichia , and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. Vector-Borne and Zoonotic Diseases, 17(8), 527–538. https://doi.org/10.1089/vbz.2016.2091 |
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Grant Number: 01188-A Research Program Area: Lung and Respiratory Disease |
Capacity for Respiratory-Based Thermoregulation in Brachycephalic Breeds Davis, M. S., Cummings, S. L., & Payton, M. E. (2017). Effect of brachycephaly and body condition score on respiratory thermoregulation of healthy dogs. Journal of the American Veterinary Medical Association, 251(10), 1160–1165. https://doi.org/10.2460/javma.251.10.1160 |
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Grant Number: 00898-A Research Program Area: Cardiology |
Diagnosis and Progression of Acquired Mitral Valve Disease in Whippets Stepien, R. L., Kellihan, H. B., & Luis Fuentes, V. (2017). Prevalence and diagnostic characteristics of non-clinical mitral regurgitation murmurs in North American Whippets. Journal of Veterinary Cardiology, 19(4), 317–324. https://doi.org/10.1016/j.jvc.2017.04.004 |
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Grant Number: 02124-A Research Program Area: Reproductive Conditions |
Determining the Characteristics of Sperm That Accurately Predict Fertility of Stud Dogs Hesser, A., Darr, C., Gonzales, K., Power, H., Scanlan, T., Thompson, J., … Meyers, S. (2017). Semen evaluation and fertility assessment in a purebred dog breeding facility. Theriogenology, 87, 115–123. https://doi.org/10.1016/j.theriogenology.2016.08.012 |
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Grant Number: 02257 Research Program Area: Neurology, Epilepsy Initiative |
Identification of Genetic Risk Factors for Canine Epilepsy
Villani, N. A., Bullock, G., Michaels, J. R., Yamato, O., O’Brien, D. P., Mhlanga Mutangadura, T., … Katz, M. L. (2019). A mixed breed dog with neuronal ceroid lipofuscinosis is homozygous for a CLN5 nonsense mutation previously identified in border collies and Australian cattle dogs. Molecular Genetics and Metabolism. https://doi.org/10.1016/j.ymgme.2019.04.003 |
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Grant Number: 02118-A Research Program Area: Reproductive Conditions |
Targeting the Mechanism of Bacterial Adherence during Pyometra to Develop an Effective, Non-Invasive Treatment for Disease Gabriel, C., Becher-Deichsel, A., Hlavaty, J., Mair, G., & Walter, I. (2016). The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra. Theriogenology, 85(9), 1599-1609.e2. https://doi.org/10.1016/j.theriogenology.2016.01.021 Mair, G., Unger, H., & Gabriel, C. (2017). Combining RPL27 with OAZ1 or RPL8 as Universal Normalizers of Gene Expression in Canine Endometrial Studies. International Journal of Veterinary Science and Technology, 1(1), 23–24. |
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Grant Number: 1731 Research Program Area: Neurology |
A Novel Approach to Understanding How Meningoencephalomyelitis Develops In Dogs Jeffery, N. D., Barker, A. K., Alcott, C. J., Levine, J. M., Meren, I., Wengert, J., … Suchodolski, J. S. (2017). The Association of Specific Constituents of the Fecal Microbiota with Immune-Mediated Brain Disease in Dogs. PLOS ONE, 12(1), e0170589. https://doi.org/10.1371/journal.pone.0170589 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
