01876-A: Ensuring That Emerging Stem Cell Treatments Do Not Activate or Exacerbate Cancer in Dogs
Grant Status: Open
Treatment with adult stem cells is showing promise for a variety of immune, inflammatory and degenerative diseases in dogs and humans. However, there is accumulating evidence that stem cells may promote tumor growth through direct stimulation of tumor cell proliferation, migration and invasion and suppression of programmed cell death (apoptosis), as well as indirectly through stimulation of blood vessel growth and suppression of the immune system. Cancer is generally a disease of older dogs, the same population of patients likely to receive stem cell therapy for other diseases. In this pilot study, Dr. Thamm proposes to investigate the effects of canine stem cell factors on proliferation, apoptosis, invasion and migration in a large panel of canine tumor and blood vessel cell lines. The knowledge of whether stem cells can promote tumor growth will address a key safety concern regarding the application of stem cell-based therapies in dogs with known or suspected cancer, and will inform decision making regarding stem cell use in an aged dog population at risk for tumor development.
Manuscript in preparation.
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