Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02071 Research Program Area: Oncology |
Development of a Therapeutic Brain Tumor Vaccine Olin, M. R., Pluhar, G. E., Andersen, B. M., Shaver, R., Waldron, N. N., & Moertel, C. L. (2014). Victory and Defeat in the Induction of a Therapeutic Response through Vaccine Therapy for Human and Canine Brain Tumors: A Review of the State of the Art. Critical Reviews in Immunology, 34(5), 399–432. https://doi.org/10.1615/CritRevImmunol.2014011577 Pluhar, G. E., Pennell, C. A., & Olin, M. R. (2015). CD8+ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity. Critical Reviews in Immunology, 35(2), 153–172. https://doi.org/10.1615/CritRevImmunol.2015013607 |
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Grant Number: 01704-A Research Program Area: Oncology - Osteosarcoma |
Expression and distribution of Receptor Activator of Nuclear factor kB Ligand (RANK-L) and its receptor RANK in canine osteosarcoma Marley, K., Bracha, S., & Seguin, B. (2015). Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL. Experimental Cell Research, 338(1), 32–38. https://doi.org/10.1016/j.yexcr.2015.08.001
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Grant Number: 01533-A Research Program Area: Musculoskeletal Conditions and Disease |
Development of a Canine Stifle Computer Model for Evaluation of Cranial Cruciate Ligament Deficiency >Brown, N. P., Bertocci, G. E., & Marcellin-Little, D. J. (2013). Development of a Canine Stifle Computer Model to Evaluate Cranial Cruciate Ligament Deficiency. Journal of Mechanics in Medicine and Biology, 13(02), 1350043. https://doi.org/10.1142/S0219519413500437 Brown, N. P., Bertocci, G. E., & Marcellin-Little, D. J. (2014). Evaluation of varying morphological parameters on the biomechanics of a cranial cruciate ligament–deficient or intact canine stifle joint with a computer simulation model. American Journal of Veterinary Research, 75(1), 26–33. https://doi.org/10.2460/ajvr.75.1.26 Brown, N. P., Bertocci, G. E., & Marcellin-Little, D. J. (2015). Influence of biomechanical parameters on cranial cruciate ligament–deficient or –intact canine stifle joints assessed by use of a computer simulation model. American Journal of Veterinary Research, 76(11), 952–958. https://doi.org/10.2460/ajvr.76.11.952 |
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Grant Number: 01726-A Research Program Area: Oncology - Osteosarcoma |
Identifying Growth Factors That Promote the Spread of Osteosarcoma JM Gullaba, SC Helfand, K Marley: Effects of crizotinib on canine osteosarcoma migration and invasion. Abstract O-14 in: J Vet Int Medicine 27:685, 2013. Marley, K., Gullaba, J., Seguin, B., Gelberg, H. B., & Helfand, S. C. (2015). Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs. Translational Oncology, 8(4), 231–238. https://doi.org/10.1016/j.tranon.2015.03.006
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Grant Number: 02193-A Research Program Area: Reproductive Conditions |
Identifying the Genetic Basis of Fetal Anasarca in Bulldogs/Canines Hekman, J. P., Johnson, J. L., & Kukekova, A. V. (2015). Transcriptome Analysis in Domesticated Species: Challenges and Strategies. Bioinformatics and Biology Insights, 9S4, BBI.S29334. https://doi.org/10.4137/BBI.S29334 |
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Grant Number: 372 Research Program Area: Endocrinology |
Determination of Breed-Specific Reference Ranges for Assessing Thyroid Function in Several Breeds Hegstad-Davies, R. L., Torres, S. M. F., Sharkey, L. C., Gresch, S. C., Muñoz-Zanzi, C. A., & Davies, P. R. (2015). Breed-specific reference intervals for assessing thyroid function in seven dog breeds. Journal of Veterinary Diagnostic Investigation, 27(6), 716–727. https://doi.org/10.1177/1040638715606953
Sharkey, L., Gjevre, K., Hegstad-Davies, R., Torres, S., & Muñoz-Zanzi, C. (2009). Breed-associated variability in serum biochemical analytes in four large-breed dogs. Veterinary Clinical Pathology, 38(3), 375–380. https://doi.org/10.1111/j.1939-165X.2009.00134.x
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Grant Number: 01168-A Research Program Area: Oncology - Hemangiosarcoma |
Identifying Mutations in Genes Associated with Canine Hemangiosarcoma: Denser Fine Mapping of the Associated Locus in Chromosome 5 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
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Grant Number: 01503-A Research Program Area: Oncology - Osteosarcoma |
Rational Development of Targeted Therapy - Aurora Kinase Inhibition in Osteosarcoma
Cannon, C. M., Pozniak, J., Scott, M. C., Ito, D., Gorden, B. H., Graef, A. J., & Modiano, J. F. (2015). Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors. Veterinary and Comparative Oncology, 13(1), 48–59. https://doi.org/10.1111/vco.12018 |
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Grant Number: 02092-A Research Program Area: Oncology - Lymphoma |
Developing the Use of a Novel Imaging Technique to Define a Dog's Potential Responsiveness to Chemotherapy
Custead, M. R., An, R., Turek, J. J., Moore, G. E., Nolte, D. D., & Childress, M. O. (2015). Predictive value of ex vivo biodynamic imaging in determining response to chemotherapy in dogs with spontaneous non-Hodgkin’s lymphomas: a preliminary study. Convergent Science Physical Oncology, 1(1), 015003. https://doi.org/10.1088/2057-1739/1/1/015003
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Grant Number: 01911-A Research Program Area: Oncology - Hemangiosarcoma |
Enhanced Hemangiosarcoma Therapy Using a Novel Combination of Drugs That Target Tumor Proliferation Andersen, N. J., Nickoloff, B. J., Dykema, K. J., Boguslawski, E. A., Krivochenitser, R. I., Froman, R. E., … Duesbery, N. S. (2013). Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma. Molecular Cancer Therapeutics, 12(9), 1701–1714. https://doi.org/10.1158/1535-7163.MCT-12-0893
Andersen, Nicholas J., Boguslawski, E. B., Kuk, C. Y., Chambers, C. M., & Duesbery, N. S. (2015). Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts. International Journal of Oncology, 47(1), 71–80. https://doi.org/10.3892/ijo.2015.2989
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Grant Number: 01924-A Research Program Area: Blood Disorders |
Creation of Platelet Function Testing Guidelines to Enhance Diagnosis and Prognosis of Bleeding Disorders in Dogs Blois, S. L., Lang, S. T., Wood, R. D., & Monteith, G. (2015). Biologic variability and correlation of platelet function testing in healthy dogs. Veterinary Clinical Pathology, 44(4), 503–510. |
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Grant Number: 00848-A Research Program Area: Oncology |
Evaluation of Neutrophil Function in Treated Tumor-Bearing Dogs LeBlanc, A. K., LeBlanc, C. J., Rohrbach, B. W., & Kania, S. A. (2015). Serial evaluation of neutrophil function in tumour-bearing dogs undergoing chemotherapy. Veterinary and Comparative Oncology, 13(1), 20–27. https://doi.org/10.1111/vco.12015 |
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Grant Number: 01868-A Research Program Area: General Canine Health |
Development of a Novel System for Controlled Drug Delivery in the Dog Jia, H., & Kerr, L. L. (2013). Sustained Ibuprofen Release Using Composite Poly(Lactic-co-Glycolic Acid)/Titanium Dioxide Nanotubes from Ti Implant Surface. Journal of Pharmaceutical Sciences, 102(7), 2341–2348. https://doi.org/10.1002/jps.23580
Jia, H., & Kerr, L. L. (2015). Kinetics of drug release from drug carrier of polymer/TiO 2 nanotubes composite-pH dependent study. Journal of Applied Polymer Science, 132(7), n/a-n/a. https://doi.org/10.1002/app.41570 |
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Grant Number: 2447 Research Program Area: Endocrinology |
Genetic Determinants of Susceptibility to Hypothyroid Disease in Dogs Bianchi, M., Dahlgren, S., Massey, J., Dietschi, E., Kierczak, M., Lund-Ziener, M., … Rosengren Pielberg, G. (2015). A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12. PLOS ONE, 10(8), e0134720. https://doi.org/10.1371/journal.pone.0134720
Kennedy, L. J., Barnes, A., Short, A., Brown, J. J., Seddon, J., Fleeman, L., … Ollier, W. E. R. (2007). Canine DLA diversity: 3. Disease studies. Tissue Antigens, 69, 292–296. https://doi.org/10.1111/j.1399-0039.2006.00781.x
Kennedy, L. J., Huson, H. J., Leonard, J., Angles, J. M., Fox, L. E., Wojciechowski, J. W., … Happ, G. M. (2006). Association of hypothyroid disease in Doberman Pinscher dogs with a rare major histocompatibility complex DLA class II haplotype. Tissue Antigens, 67(1), 53–56. https://doi.org/10.1111/j.1399-0039.2005.00518.x
Kennedy, L. J., Quarmby, S., Happ, G. M., Barnes, A., Ramsey, I. K., Dixon, R. M., … Ollier, W. E. R. (2006). Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele. Tissue Antigens, 68(1), 82–86. https://doi.org/10.1111/j.1399-0039.2006.00614.x
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Grant Number: 00593B Research Program Area: Oncology - Hemangiosarcoma |
Mapping Genes Associated with Canine Hemangiosarcoma Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
