Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01147 Research Program Area: Oncology - Hemangiosarcoma |
Identifying Mutations in Genes Associated with Canine Hemangiosarcoma >Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
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Grant Number: 01684-A Research Program Area: Endocrinology |
Improved Method for Early Diagnosis of Atypical Cushing's Disease Frank, L. A., Henry, G. A., Whittemore, J. C., Enders, B. D., Mawby, D. I., & Rohrbach, B. W. (2015). Serum Cortisol Concentrations in Dogs with Pituitary-Dependent Hyperadrenocorticism and Atypical Hyperadrenocorticism. Journal of Veterinary Internal Medicine, 29(1), 193–199. https://doi.org/10.1111/jvim.12500 |
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Grant Number: 01949-A Research Program Area: Oncology - Osteosarcoma |
Targeting the Cell's Activation Machinery to Halt Tumor Metastasis in Canine Osteosarcoma Marley, K., Bracha, S., & Seguin, B. (2015). Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL. Experimental Cell Research, 338(1), 32–38. https://doi.org/10.1016/j.yexcr.2015.08.001
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Grant Number: 01169-A Research Program Area: Oncology - Hemangiosarcoma |
Identifying Mutations in Genes Associated with Canine Hemangiosarcoma: Denser Fine Mapping of the Associated Locus in Chromosome 26 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
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Grant Number: 1424 Research Program Area: Musculoskeletal Conditions and Disease |
Genetic Analysis of Cleft Palate/Lip Wolf, Z. T., Brand, H. A., Shaffer, J. R., Leslie, E. J., Arzi, B., Willet, C. E., … Bannasch, D. L. (2015). Genome-Wide Association Studies in Dogs and Humans Identify ADAMTS20 as a Risk Variant for Cleft Lip and Palate. PLOS Genetics, 11(3), e1005059. https://doi.org/10.1371/journal.pgen.1005059
Wolf, Z. T., Leslie, E. J., Arzi, B., Jayashankar, K., Karmi, N., Jia, Z., … Bannasch, D. L. (2014). A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. PLoS Genetics, 10(4), e1004257. https://doi.org/10.1371/journal.pgen.1004257
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Grant Number: 1612 Research Program Area: Ophthalmology |
Regulation of Inflammation to Prevent Cataract Surgery Complications Chandler, H. L., Gervais, K. J., Lutz, E. A., Curto, E. M., Matusow, R. B., Wilkie, D. A., & Gemensky-Metzler, A. J. (2015). Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death. Experimental Eye Research, 134, 63–72. https://doi.org/10.1016/j.exer.2015.03.020 |
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Grant Number: 01924-A Research Program Area: Blood Disorders |
Creation of Platelet Function Testing Guidelines to Enhance Diagnosis and Prognosis of Bleeding Disorders in Dogs Blois, S. L., Lang, S. T., Wood, R. D., & Monteith, G. (2015). Biologic variability and correlation of platelet function testing in healthy dogs. Veterinary Clinical Pathology, 44(4), 503–510. |
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Grant Number: 00848-A Research Program Area: Oncology |
Evaluation of Neutrophil Function in Treated Tumor-Bearing Dogs LeBlanc, A. K., LeBlanc, C. J., Rohrbach, B. W., & Kania, S. A. (2015). Serial evaluation of neutrophil function in tumour-bearing dogs undergoing chemotherapy. Veterinary and Comparative Oncology, 13(1), 20–27. https://doi.org/10.1111/vco.12015 |
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Grant Number: 01854-A Research Program Area: Behavior |
Identifying the Cause of Canine Compulsive Disorder Hall, N. J., Protopopova, A., & Wynne, C. D. L. (2015). The role of environmental and owner-provided consequences in canine stereotypy and compulsive behavior. Journal of Veterinary Behavior, 10(1), 24–35. https://doi.org/10.1016/j.jveb.2014.10.005
Protopopova, A., Hall, N. J., & Wynne, C. D. L. (2014). Association between increased behavioral persistence and stereotypy in the pet dog. Behavioural Processes, 106, 77–81. https://doi.org/10.1016/j.beproc.2014.04.009 |
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Grant Number: 02092-A Research Program Area: Oncology - Lymphoma |
Developing the Use of a Novel Imaging Technique to Define a Dog's Potential Responsiveness to Chemotherapy
Custead, M. R., An, R., Turek, J. J., Moore, G. E., Nolte, D. D., & Childress, M. O. (2015). Predictive value of ex vivo biodynamic imaging in determining response to chemotherapy in dogs with spontaneous non-Hodgkin’s lymphomas: a preliminary study. Convergent Science Physical Oncology, 1(1), 015003. https://doi.org/10.1088/2057-1739/1/1/015003
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Grant Number: 01911-A Research Program Area: Oncology - Hemangiosarcoma |
Enhanced Hemangiosarcoma Therapy Using a Novel Combination of Drugs That Target Tumor Proliferation Andersen, N. J., Nickoloff, B. J., Dykema, K. J., Boguslawski, E. A., Krivochenitser, R. I., Froman, R. E., … Duesbery, N. S. (2013). Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma. Molecular Cancer Therapeutics, 12(9), 1701–1714. https://doi.org/10.1158/1535-7163.MCT-12-0893
Andersen, Nicholas J., Boguslawski, E. B., Kuk, C. Y., Chambers, C. M., & Duesbery, N. S. (2015). Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts. International Journal of Oncology, 47(1), 71–80. https://doi.org/10.3892/ijo.2015.2989
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Grant Number: 02081-A Research Program Area: Oncology - Hemangiosarcoma |
Integrating Cutting Edge Science with Scientific Training to Defeat Hemangiosarcoma Rodriguez, A. M., Graef, A. J., LeVine, D. N., Cohen, I. R., Modiano, J. F., & Kim, J.-H. (2015). Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma. Journal of Veterinary Internal Medicine, 29(4), 1088–1097. https://doi.org/10.1111/jvim.13570
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Grant Number: 1594 Research Program Area: Ophthalmology |
Identifying the Genes Associated with Glaucoma Ahram, D. F., Cook, A. C., Kecova, H., Grozdanic, S. D., & Kuehn, M. H. (2014). Identification of genetic loci associated with primary angle-closure. Molecular Vision, 14.
Ahram, D. F., Grozdanic, S. D., Kecova, H., Henkes, A., Collin, R. W. J., & Kuehn, M. H. (2015). Variants in Nebulin (NEB) Are Linked to the Development of Familial Primary Angle Closure Glaucoma in Basset Hounds. PLOS ONE, 10(5), e0126660. https://doi.org/10.1371/journal.pone.0126660 |
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Grant Number: 01524-A Research Program Area: Oncology - Lymphoma |
Leukocyte Oxidative Burst Activity in Peripheral Blood of Dogs with Lymphoma Axiak-Bechtel, S., Fowler, B., Yu, D. H., Amorim, J., Tsuruta, K., & DeClue, A. (2014). Chemotherapy and remission status do not alter pre-existing innate immune dysfunction in dogs with lymphoma. Research in Veterinary Science, 97(2), 230–237. https://doi.org/10.1016/j.rvsc.2014.07.009 Axiak-Bechtel, S. M., Tsuruta, K., Amorim, J., Donaldson, R., Lino, G., Honaker, A., … DeClue, A. (2015). Effects of tramadol and o-desmethyltramadol on canine innate immune system function. Veterinary Anaesthesia and Analgesia, 42(3), 260–268. https://doi.org/10.1111/vaa.12201 |
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Grant Number: 02111-A Research Program Area: Dermatology and Allergic Disease |
Evaluating the Contribution of Fungal Infection to the Pathogenesis of Atopic Dermatitis: Putting Evidence under the Use of Antifungal Medication
Meason-Smith, C., Diesel, A., Patterson, A. P., Older, C. E., Mansell, J. M., Suchodolski, J. S., & Rodrigues Hoffmann, A. (2015). What is living on your dog’s skin? Characterization of the canine cutaneous mycobiota and fungal dysbiosis in canine allergic dermatitis. FEMS Microbiology Ecology, 91(12), fiv139. https://doi.org/10.1093/femsec/fiv139 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
