Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 954 Research Program Area: Neurology |
Identification of Genes Causing Chiari I Malformation with Syringomelia in the Cavalier King Charles Spaniel Lemay, P., Knowler, S. P., Bouasker, S., Nédélec, Y., Platt, S., Freeman, C., … Kibar, Z. (2014). Quantitative Trait Loci (QTL) Study Identifies Novel Genomic Regions Associated to Chiari-Like Malformation in Griffon Bruxellois Dogs. PLoS ONE, 9(4), e89816. https://doi.org/10.1371/journal.pone.0089816 |
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Grant Number: 01545-A Research Program Area: Oncology - Lymphoma |
Pilot Study to Assess Folate Receptor Expression in Canine High-Grade Multicentric Lymphoma Childress, M. O., Dhawan, D., Leamon, C. P., Miller, M. A., Ramos-Vara, J. A., Naughton, J. F., … Knapp, D. W. (2014). Assessment of folate receptor expression and folate uptake in multicentric lymphomas in dogs. American Journal of Veterinary Research, 75(2), 187–194. https://doi.org/10.2460/ajvr.75.2.187
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Grant Number: 1455 Research Program Area: Neurology |
Identification of Genes That Confer Risk for Inflammation of the Brain Barber, Renee M., Schatzberg, S. J., Corneveaux, J. J., Allen, A. N., Porter, B. F., Pruzin, J. J., … Huentelman, M. J. (2011). Identification of Risk Loci for Necrotizing Meningoencephalitis in Pug Dogs. Journal of Heredity, 102(Suppl_1), S40–S46. https://doi.org/10.1093/jhered/esr048
Barber, R.M., Porter, B. F., Li, Q., May, M., Claiborne, M. K., Allison, A. B., … Schatzberg, S. J. (2012). Broadly Reactive Polymerase Chain Reaction for Pathogen Detection in Canine Granulomatous Meningoencephalomyelitis and Necrotizing Meningoencephalitis. Journal of Veterinary Internal Medicine, 26(4), 962–968. https://doi.org/10.1111/j.1939-1676.2012.00954.x
Schrauwen, I., Barber, R. M., Schatzberg, S. J., Siniard, A. L., Corneveaux, J. J., Porter, B. F., … Huentelman, M. J. (2014). Identification of Novel Genetic Risk Loci in Maltese Dogs with Necrotizing Meningoencephalitis and Evidence of a Shared Genetic Risk across Toy Dog Breeds. PLoS ONE, 9(11), e112755. https://doi.org/10.1371/journal.pone.0112755 |
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Grant Number: 01159-A Research Program Area: Immunology and Infectious Disease |
Detection of Brucellosis canis DNA in Canine Blood Via qPCR Analysis Kauffman, L. K., Bjork, J. K., Gallup, J. M., Boggiatto, P. M., Bellaire, B. H., & Petersen, C. A. (2014). Early detection of Brucella canis via quantitative polymerase chain reaction analysis. Zoonoses and Public Health, 61(1), 48–54. https://doi.org/10.1111/zph.12041
Petersen, C. A. (2009). New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown. Interdisciplinary Perspectives on Infectious Diseases, 2009, 1–5. https://doi.org/10.1155/2009/802712
Petersen, C. A., & Barr, S. C. (2009). Canine Leishmaniasis in North America: Emerging or Newly Recognized? Veterinary Clinics of North America: Small Animal Practice, 39(6), 1065–1074. https://doi.org/10.1016/j.cvsm.2009.06.008 |
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Grant Number: 01064-A Research Program Area: Oncology |
Immunocytochemical Detection and siRNA-Mediated Knockdown of Survivin in Canine Lymphoma Shoeneman, J. K., Ehrhart, E. J., Charles, J. B., & Thamm, D. H. (2014). Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma. Veterinary and Comparative Oncology, 14(2), e45–e57. https://doi.org/10.1111/vco.12104 Shoeneman, J. K., Ehrhart, E. J., Eickhoff, J. C., Charles, J. B., Powers, B. E., & Thamm, D. H. (2012). Expression and Function of Survivin in Canine Osteosarcoma. Cancer Research, 72(1), 249–259. https://doi.org/10.1158/0008-5472.CAN-11-2315 |
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Grant Number: 01480 Research Program Area: Immunology and Infectious Disease |
Leptospirosis: An Emerging Health Concern for Field Trial and Hunting Dogs Hennebelle, J. H., Sykes, J. E., Carpenter, T. E., & Foley, J. (2013). Spatial and temporal patterns of Leptospira infection in dogs from northern California: 67 cases (2001–2010). Journal of the American Veterinary Medical Association, 242(7), 941–947. https://doi.org/10.2460/javma.242.7.941 Hennebelle, J. H., Sykes, J. E., & Foley, J. (2014). Risk Factors Associated with Leptospirosis in Dogs from Northern California: 2001–2010. Vector-Borne and Zoonotic Diseases, 14(10), 733–739. https://doi.org/10.1089/vbz.2014.1624 |
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Grant Number: 1418 Research Program Area: Oncology - Lymphoma |
Harnessing a Dog's Own Immune System to Kill Lymphoma Tumor Cells O’Connor, C. M., & Wilson-Robles, H. (2014). Developing T Cell Cancer Immunotherapy in the Dog with Lymphoma. ILAR Journal, 55(1), 169–181. https://doi.org/10.1093/ilar/ilu020
O’Connor, Colleen M., Sheppard, S., Hartline, C. A., Huls, H., Johnson, M., Palla, S. L., … Cooper, L. J. N. (2012). Adoptive T-cell therapy improves treatment of canine non–Hodgkin lymphoma post chemotherapy. Scientific Reports, 2(1). https://doi.org/10.1038/srep00249
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Grant Number: 407 Research Program Area: Neurology |
The Genetics of Canine Cerebellar Degeneration Agler, C., Nielsen, D. M., Urkasemsin, G., Singleton, A., Tonomura, N., Sigurdsson, S., … Olby, N. J. (2014). Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24. PLoS Genetics, 10(2), e1003991. https://doi.org/10.1371/journal.pgen.1003991 |
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Grant Number: 00841-A Research Program Area: Oncology |
Pharmacokinetics and Phase I Clinical Trial of High-Dose Intermittent Oral Artemisinin in Dogs with Spontaneous Tumors Hosoya, K., Couto, C. G., London, C. A., Kisseberth, W. C., Phelps, M. A., & Dalton, J. T. (2014). Comparison of High-Dose Intermittent and Low-Dose Continuous Oral Artemisinin in Dogs With Naturally Occurring Tumors. Journal of the American Animal Hospital Association, 50(6), 390–395. https://doi.org/10.5326/JAAHA-MS-6145 |
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Grant Number: 01529-A Research Program Area: Cardiology |
Platelet, myocardial, and valvular serotonin concentrations in healthy dogs and dogs with mitral valve disease Cremer, S. E., Singletary, G. E., Olsen, L. H., Wallace, K., Häggström, J., Ljungvall, I., … Oyama, M. A. (2014). Serotonin Concentrations in Platelets, Plasma, Mitral Valve Leaflet, and Left Ventricular Myocardial Tissue in Dogs with Myxomatous Mitral Valve Disease. Journal of Veterinary Internal Medicine, 28(5), 1534–1540. https://doi.org/10.1111/jvim.12420 |
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Grant Number: 01472 Research Program Area: Oncology |
Enhanced Killing of Malignant Histiocytosis with a Novel Combination of Anti-Tumor Drugs Hafeman, S. D., Varland, D., & Dow, S. W. (2012). Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Veterinary and Comparative Oncology, 10(1), 44–56. https://doi.org/10.1111/j.1476-5829.2011.00274.x
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Grant Number: 01753 Research Program Area: Cardiology |
Identification of Genetic Factors That Alter the Severity of Cardiomyopathy Meurs, K. M., Stern, J. A., Reina-Doreste, Y., Spier, A. W., Koplitz, S. L., & Baumwart, R. D. (2014). Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study. Journal of Veterinary Internal Medicine, 28(4), 1214–1220. https://doi.org/10.1111/jvim.12385 |
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Grant Number: 00582-A Research Program Area: Ophthalmology |
Identification of Canine Microsatellites Associated with Genes Known to Cause Inherited Cataract Conditions in Humans Mellersh, C. S. (2014). The genetics of eye disorders in the dog. Canine Genetics and Epidemiology, 1(1), 3. https://doi.org/10.1186/2052-6687-1-3
Mellersh, C. S., Pettitt, L., Forman, O. P., Vaudin, M., & Barnett, K. C. (2006). Identification of mutations in HSF4 in dogs of three different breeds with hereditary cataracts. Veterinary Ophthalmology, 9(5), 369–378. https://doi.org/10.1111/j.1463-5224.2006.00496.x |
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Grant Number: 01651 Research Program Area: Oncology - Lymphoma |
Serum Antibody Reactivity Profiling for Canine Lymphoma Detection and Monitoring Johnston, S. A., Thamm, D. H., & Legutki, J. B. (2014). The immunosignature of canine lymphoma: characterization and diagnostic application. BMC Cancer, 14(1). https://doi.org/10.1186/1471-2407-14-657
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Grant Number: 580 Research Program Area: Musculoskeletal Conditions and Disease |
Patella Luxation in Dogs: A Molecular Approach Lavrijsen, I. C. M., Heuven, H. C. M., Breur, G. J., Leegwater, P. A. J., Meutstege, F. J., & Hazewinkel, H. A. W. (2013). Phenotypic and genetic trends of patellar luxation in Dutch Flat-Coated Retrievers. Animal Genetics, 44(6), 736–741. https://doi.org/10.1111/age.12077
Lavrijsen, Ineke C M, Leegwater, P. A. J., Wangdee, C., van Steenbeek, F. G., Schwencke, M., Breur, G. J., … Hazewinkel, H. A. W. (2014). Genome-wide survey indicates involvement of loci on canine chromosomes 7 and 31 in patellar luxation in Flat-Coated Retrievers. BMC Genetics, 15(1), 64. https://doi.org/10.1186/1471-2156-15-64
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Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
