Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 1004 Research Program Area: Neurology |
Syringomyelia in the Brussels Griffon: Magnetic Resonance Imaging Findings, Clinicopathology, and Prevalence Freeman, A. C., Platt, S. R., Kent, M., Huguet, E., Rusbridge, C., & Holmes, S. (2014). Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogs. Journal of Veterinary Internal Medicine, 28(5), 1551–1559. https://doi.org/10.1111/jvim.12421 Knowler, S. P., McFadyen, A. K., Freeman, C., Kent, M., Platt, S. R., Kibar, Z., & Rusbridge, C. (2014). Quantitative Analysis of Chiari-Like Malformation and Syringomyelia in the Griffon Bruxellois Dog. PLoS ONE, 9(2), e88120. https://doi.org/10.1371/journal.pone.0088120 |
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Grant Number: 920 Research Program Area: Neurology |
Genetic Basis of Polyneuropathy in Leonbergers Ekenstedt, K. J., Becker, D., Minor, K. M., Shelton, G. D., Patterson, E. E., Bley, T., … Mickelson, J. R. (2014). An ARHGEF10 Deletion Is Highly Associated with a Juvenile-Onset Inherited Polyneuropathy in Leonberger and Saint Bernard Dogs. PLoS Genetics, 10(10), e1004635. https://doi.org/10.1371/journal.pgen.1004635
Pemberton, T. J., Choi, S., Mayer, J. A., Li, F.-Y., Gokey, N., Svaren, J., … Duncan, I. D. (2014). A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination. Glia, 62(1), 39–51. https://doi.org/10.1002/glia.22582 |
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Grant Number: 1130 Research Program Area: Oncology - Lymphoma |
Measurement of Minimal Residual Disease Using Real Time PCR in Canine Lymphoma Johnston, S. A., Thamm, D. H., & Legutki, J. B. (2014). The immunosignature of canine lymphoma: Characterization and diagnostic application. BMC Cancer, 14(1).https://doi.org/10.1186/1471-2407-14-657 Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Research, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z |
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Grant Number: 00582-A Research Program Area: Ophthalmology |
Identification of Canine Microsatellites Associated with Genes Known to Cause Inherited Cataract Conditions in Humans Mellersh, C. S. (2014). The genetics of eye disorders in the dog. Canine Genetics and Epidemiology, 1(1), 3. https://doi.org/10.1186/2052-6687-1-3
Mellersh, C. S., Pettitt, L., Forman, O. P., Vaudin, M., & Barnett, K. C. (2006). Identification of mutations in HSF4 in dogs of three different breeds with hereditary cataracts. Veterinary Ophthalmology, 9(5), 369–378. https://doi.org/10.1111/j.1463-5224.2006.00496.x |
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Grant Number: 01505-A Research Program Area: Immunology and Infectious Disease |
Identification of Biological Marker of Idiopathic Immune-Mediated Polyarthropathy to Enable Non-Invasive Diagnosis and Prognosis Foster, J. D., Sample, S., Kohler, R., Watson, K., Muir, P., & Trepanier, L. A. (2014). Serum Biomarkers of Clinical and Cytologic Response in Dogs with Idiopathic Immune-Mediated Polyarthropathy. Journal of Veterinary Internal Medicine, 28(3), 905–911. https://doi.org/10.1111/jvim.12351 |
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Grant Number: 01495-A Research Program Area: Blood Disorders |
Comparison of cellular function in two canine platelet concentrates Hoareau, G. L., Jandrey, K. E., Burges, J., Bremer, D., & Tablin, F. (2014). Comparison of the platelet-rich plasma and buffy coat protocols for preparation of canine platelet concentrates. Veterinary Clinical Pathology, 43(4), 513–518.https://doi.org/10.1111/vcp.12195 |
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Grant Number: 821 Research Program Area: Neurology |
Phenotypic Characterization and Mapping Genes Associated with Canine Degenerative Myelopathy in the Boxer Dog Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106
Coates, J. R., March, P. A., Oglesbee, M., Ruaux, C. G., Olby, N. J., Berghaus, R. D., … Williams, D. A. (2007). Clinical Characterization of a Familial Degenerative Myelopathy in Pembroke Welsh Corgi Dogs. Journal of Veterinary Internal Medicine, 21, 1323–1331.
Crisp, M. J., Beckett, J., Coates, J. R., & Miller, T. M. (2013). Canine degenerative myelopathy: Biochemical characterization of superoxide dismutase 1 in the first naturally occurring non-human amyotrophic lateral sclerosis model. Experimental Neurology, 248, 1–9. https://doi.org/10.1016/j.expneurol.2013.05.009
March, P. A., Coates, J. R., Abyad, R. J., Williams, D. A., O’Brien, D. P., Olby, N. J., … Oglesbee, M. (2009). Degenerative Myelopathy in 18 Pembroke Welsh Corgi Dogs. Vet Pathol, 10.
Zeng, R., Coates, J. R., Johnson, G. C., Hansen, L., Awano, T., Kolicheski, A., … Johnson, G. S. (2014). Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy. Journal of Veterinary Internal Medicine, 28(2), 515–521. https://doi.org/10.1111/jvim.12317 |
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Grant Number: 945 Research Program Area: Gastrointestinal Disease |
Mucosal Gene Expression Profiles in Canine Inflammatory Bowel Disease Jergens, A., Young, J., Moore, D., Wang, C., Hostetter, J., Augustine, L., … Mosher, C. (2014). Bcl-2/Caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease. Veterinary Immunology and Immunopathology, 158(3–4), 167–174. https://doi.org/10.1016/j.vetimm.2014.01.004
Suchodolski, J. S., Dowd, S. E., Wilke, V., Steiner, J. M., & Jergens, A. E. (2012). 16S rRNA Gene Pyrosequencing Reveals Bacterial Dysbiosis in the Duodenum of Dogs with Idiopathic Inflammatory Bowel Disease. PLoS ONE, 7(6), e39333. https://doi.org/10.1371/journal.pone.0039333
Suchodolski, J. S., Xenoulis, P. G., Paddock, C. G., Steiner, J. M., & Jergens, A. E. (2010). Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease. Veterinary Microbiology, 142(3–4), 394–400. https://doi.org/10.1016/j.vetmic.2009.11.002
Wilke, V. L., Nettleton, D., Wymore, M. J., Gallup, J. M., Demirkale, C. Y., Ackermann, M. R., … Jergens, A. E. (2012). Gene expression in intestinal mucosal biopsy specimens obtained from dogs with chronic enteropathy. American Journal of Veterinary Research, 73(8), 1219–1229. https://doi.org/10.2460/ajvr.73.8.1219
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Grant Number: 01935-B Research Program Area: Gastrointestinal Disease |
Abnormalities in the Stomach's Ability to Contract Predisposes Large-Breed Dogs to Bloat Gazzola, K. M., & Nelson, L. L. (2014). The relationship between gastrointestinal motility and gastric dilatation-volvulus in dogs. Top Companion Anim Med, 29(3), 64-66. doi:10.1053/j.tcam.2014.09.006 |
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Grant Number: 00871-A Research Program Area: Gastrointestinal Disease |
Canine Anal Furunculosis Ke, X., Kennedy, L. J., Short, A. D., Seppälä, E. H., Barnes, A., Clements, D. N., … Ollier, W. E. R. (2011). Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. Animal Genetics, 42(2), 181–190. https://doi.org/10.1111/j.1365-2052.2010.02132.x
Massey, J., Short, A. D., Catchpole, B., House, A., Day, M. J., Lohi, H., … Kennedy, L. J. (2014). Genetics of canine anal furunculosis in the German Shepherd Dog. Immunogenetics, 66(5), 311–324. https://doi.org/10.1007/s00251-014-0766-5 |
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Grant Number: 01364-A Research Program Area: Musculoskeletal Conditions and Disease |
Heat shock protein 72 (HSP72) as a biomarker for acclimation to, and performance in high level physical activity in pure-bred military working dogs Bruchim, Y., Aroch, I., Eliav, A., Abbas, A., Frank, I., Kelmer, E., … Horowitz, M. (2014). Two years of combined high-intensity physical training and heat acclimatization affect lymphocyte and serum HSP70 in purebred military working dogs. Journal of Applied Physiology, 117(2), 112–118. https://doi.org/10.1152/japplphysiol.00090.2014 |
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Grant Number: 01429 Research Program Area: Oncology - Hemangiosarcoma |
Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma Kim, J.-H., Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020
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Grant Number: 1418 Research Program Area: Oncology - Lymphoma |
Harnessing a Dog's Own Immune System to Kill Lymphoma Tumor Cells O’Connor, C. M., & Wilson-Robles, H. (2014). Developing T Cell Cancer Immunotherapy in the Dog with Lymphoma. ILAR Journal, 55(1), 169–181. https://doi.org/10.1093/ilar/ilu020
O’Connor, Colleen M., Sheppard, S., Hartline, C. A., Huls, H., Johnson, M., Palla, S. L., … Cooper, L. J. N. (2012). Adoptive T-cell therapy improves treatment of canine non–Hodgkin lymphoma post chemotherapy. Scientific Reports, 2(1). https://doi.org/10.1038/srep00249
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Grant Number: 02091-A Research Program Area: Oncology |
Differentiating between Localized and Disseminated Histiocytic Sarcoma in Bernese Mountain Dogs Schoenebeck, J. J., & Ostrander, E. A. (2014). Insights into Morphology and Disease from the Dog Genome Project. Annual Review of Cell and Developmental Biology, 30(1), 535–560. https://doi.org/10.1146/annurev-cellbio-100913-012927 |
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Grant Number: 01865-A Research Program Area: Neurology |
Defining the Genes That Cause Fatal Degeneration of the Nervous System Gilliam, D., O’Brien, D. P., Coates, J. R., Johnson, G. S., Johnson, G. C., Mhlanga-Mutangadura, T., … Schnabel, R. D. (2014). A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both. Journal of Veterinary Internal Medicine, 28(3), 871–877. https://doi.org/10.1111/jvim.12355
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Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
