Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01390-A Research Program Area: Immunology and Infectious Disease |
The Use of Mycophenolate in the Treatment of Primary Immune Mediated Hemolytic Anemia West, L. D., & Hart, J. R. (2014). Treatment of idiopathic immune-mediated hemolytic anemia with mycophenolate mofetil in five dogs: Mycophenolate for treatment of IMHA in dogs. Journal of Veterinary Emergency and Critical Care, 24(2), 226–231. https://doi.org/10.1111/vec.12121
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Grant Number: 00871-A Research Program Area: Gastrointestinal Disease |
Canine Anal Furunculosis Ke, X., Kennedy, L. J., Short, A. D., Seppälä, E. H., Barnes, A., Clements, D. N., … Ollier, W. E. R. (2011). Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. Animal Genetics, 42(2), 181–190. https://doi.org/10.1111/j.1365-2052.2010.02132.x
Massey, J., Short, A. D., Catchpole, B., House, A., Day, M. J., Lohi, H., … Kennedy, L. J. (2014). Genetics of canine anal furunculosis in the German Shepherd Dog. Immunogenetics, 66(5), 311–324. https://doi.org/10.1007/s00251-014-0766-5 |
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Grant Number: 01364-A Research Program Area: Musculoskeletal Conditions and Disease |
Heat shock protein 72 (HSP72) as a biomarker for acclimation to, and performance in high level physical activity in pure-bred military working dogs Bruchim, Y., Aroch, I., Eliav, A., Abbas, A., Frank, I., Kelmer, E., … Horowitz, M. (2014). Two years of combined high-intensity physical training and heat acclimatization affect lymphocyte and serum HSP70 in purebred military working dogs. Journal of Applied Physiology, 117(2), 112–118. https://doi.org/10.1152/japplphysiol.00090.2014 |
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Grant Number: 01429 Research Program Area: Oncology - Hemangiosarcoma |
Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma Kim, J.-H., Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020
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Grant Number: 01840 Research Program Area: Reproductive Conditions |
Health Implications of Early Spay/Neuter on Canine Health Hart, B.L., L.A. Hart, A.P. Thigpen and N. H. Willits. 2014. Long-term health effects of neutering dogs: Comparison of Labrador Retrievers and Golden Retrievers. PLoS ONE 9(7): 10.1371/journal.pone.0102241. |
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Grant Number: 01505-A Research Program Area: Immunology and Infectious Disease |
Identification of Biological Marker of Idiopathic Immune-Mediated Polyarthropathy to Enable Non-Invasive Diagnosis and Prognosis Foster, J. D., Sample, S., Kohler, R., Watson, K., Muir, P., & Trepanier, L. A. (2014). Serum Biomarkers of Clinical and Cytologic Response in Dogs with Idiopathic Immune-Mediated Polyarthropathy. Journal of Veterinary Internal Medicine, 28(3), 905–911. https://doi.org/10.1111/jvim.12351 |
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Grant Number: 01495-A Research Program Area: Blood Disorders |
Comparison of cellular function in two canine platelet concentrates Hoareau, G. L., Jandrey, K. E., Burges, J., Bremer, D., & Tablin, F. (2014). Comparison of the platelet-rich plasma and buffy coat protocols for preparation of canine platelet concentrates. Veterinary Clinical Pathology, 43(4), 513–518.https://doi.org/10.1111/vcp.12195 |
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Grant Number: 821 Research Program Area: Neurology |
Phenotypic Characterization and Mapping Genes Associated with Canine Degenerative Myelopathy in the Boxer Dog Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106
Coates, J. R., March, P. A., Oglesbee, M., Ruaux, C. G., Olby, N. J., Berghaus, R. D., … Williams, D. A. (2007). Clinical Characterization of a Familial Degenerative Myelopathy in Pembroke Welsh Corgi Dogs. Journal of Veterinary Internal Medicine, 21, 1323–1331.
Crisp, M. J., Beckett, J., Coates, J. R., & Miller, T. M. (2013). Canine degenerative myelopathy: Biochemical characterization of superoxide dismutase 1 in the first naturally occurring non-human amyotrophic lateral sclerosis model. Experimental Neurology, 248, 1–9. https://doi.org/10.1016/j.expneurol.2013.05.009
March, P. A., Coates, J. R., Abyad, R. J., Williams, D. A., O’Brien, D. P., Olby, N. J., … Oglesbee, M. (2009). Degenerative Myelopathy in 18 Pembroke Welsh Corgi Dogs. Vet Pathol, 10.
Zeng, R., Coates, J. R., Johnson, G. C., Hansen, L., Awano, T., Kolicheski, A., … Johnson, G. S. (2014). Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy. Journal of Veterinary Internal Medicine, 28(2), 515–521. https://doi.org/10.1111/jvim.12317 |
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Grant Number: 945 Research Program Area: Gastrointestinal Disease |
Mucosal Gene Expression Profiles in Canine Inflammatory Bowel Disease Jergens, A., Young, J., Moore, D., Wang, C., Hostetter, J., Augustine, L., … Mosher, C. (2014). Bcl-2/Caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease. Veterinary Immunology and Immunopathology, 158(3–4), 167–174. https://doi.org/10.1016/j.vetimm.2014.01.004
Suchodolski, J. S., Dowd, S. E., Wilke, V., Steiner, J. M., & Jergens, A. E. (2012). 16S rRNA Gene Pyrosequencing Reveals Bacterial Dysbiosis in the Duodenum of Dogs with Idiopathic Inflammatory Bowel Disease. PLoS ONE, 7(6), e39333. https://doi.org/10.1371/journal.pone.0039333
Suchodolski, J. S., Xenoulis, P. G., Paddock, C. G., Steiner, J. M., & Jergens, A. E. (2010). Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease. Veterinary Microbiology, 142(3–4), 394–400. https://doi.org/10.1016/j.vetmic.2009.11.002
Wilke, V. L., Nettleton, D., Wymore, M. J., Gallup, J. M., Demirkale, C. Y., Ackermann, M. R., … Jergens, A. E. (2012). Gene expression in intestinal mucosal biopsy specimens obtained from dogs with chronic enteropathy. American Journal of Veterinary Research, 73(8), 1219–1229. https://doi.org/10.2460/ajvr.73.8.1219
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Grant Number: 01865-A Research Program Area: Neurology |
Defining the Genes That Cause Fatal Degeneration of the Nervous System Gilliam, D., O’Brien, D. P., Coates, J. R., Johnson, G. S., Johnson, G. C., Mhlanga-Mutangadura, T., … Schnabel, R. D. (2014). A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both. Journal of Veterinary Internal Medicine, 28(3), 871–877. https://doi.org/10.1111/jvim.12355
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Grant Number: 1601 Research Program Area: Hepatic Disease |
Identifying the Genetic Cause of Fatal Neonatal Liver Disease van Steenbeek, F. G., Spee, B., Penning, L. C., Kummeling, A., van Gils, I. H. M., Grinwis, G. C. M., … Leegwater, P. A. J. (2013). Altered Subcellular Localization of Heat Shock Protein 90 Is Associated with Impaired Expression of the Aryl Hydrocarbon Receptor Pathway in Dogs. PLoS ONE, 8(3), e57973. https://doi.org/10.1371/journal.pone.0057973
van Steenbeek, F. G., Van den Bossche, L., Grinwis, G. C. M., Kummeling, A., van Gils, I. H. M., Koerkamp, M. J. A. Groot., … Spee, B. (2013). Aberrant Gene Expression in Dogs with Portosystemic Shunts. PLoS ONE, 8(2), e57662. https://doi.org/10.1371/journal.pone.0057662
van Steenbeek, F. G., van den Bossche, L., Leegwater, P. A. J., & Rothuizen, J. (2012). Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein. Mammalian Genome, 23(1–2), 76–84. https://doi.org/10.1007/s00335-011-9364-0 |
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Grant Number: 00903-A Research Program Area: Ophthalmology |
Candidate Gene Investigation of Cairn Terrier Ocular Melanosis Winkler, P. A., Bartoe, J. T., Quinones, C. R., Venta, P. J., & Petersen-Jones, S. M. (2013). Exclusion of eleven candidate genes for ocular melanosis in Cairn Terriers. Journal of Negative Results in BioMedicine, 12(1). https://doi.org/10.1186/1477-5751-12-6 |
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Grant Number: 00369-A Research Program Area: Reproductive Conditions |
Analysis of the Ultrastructure of the Canine Zona Pellucida Lunn, M. O., & Wright, S. J. (2009). Imaging the Zona Pellucida of Canine and Feline Oocytes Using Scanning Electron Microscopy. Microscopy and Microanalysis, 15(01), 2–14. https://doi.org/10.1017/S1431927609090084
Lunn, M. O., & Wright, S. J. (2013). Distinct subtypes of zona pellucida morphology reflect canine oocyte viability and cumulus-oocyte complex quality. Theriogenology, 80(5), 498–506. https://doi.org/10.1016/j.theriogenology.2013.05.013
Lunn, M., & Wright, S. (2006). Analysis of the Ultrastructure of the Canine Zona Pellucida. Microscopy and Microanalysis, 12(S02), 270–271. https://doi.org/10.1017/S1431927606066281 |
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Grant Number: 02131 Research Program Area: Epilepsy Initiative |
Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy Milne, M. E., Anderson, G. A., Chow, K. E., O’Brien, T. J., Moffat, B. A., & Long, S. N. (2013). Description of technique and lower reference limit for magnetic resonance imaging of hippocampal volumetry in dogs. American Journal of Veterinary Research, 74(2), 224–231. https://doi.org/10.2460/ajvr.74.2.224 Milne, M. E., Steward, C., Firestone, S. M., Long, S. N., O’Brien, T. J., & Moffat, B. A. (2016). Development of representative magnetic resonance imaging–based atlases of the canine brain and evaluation of three methods for atlas-based segmentation. American Journal of Veterinary Research, 77(4), 395–403. https://doi.org/10.2460/ajvr.77.4.395 |
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Grant Number: 0276 Research Program Area: Cardiology |
Microarray Analysis for Cardiac Gene Expression in German Shepherd Dogs with Sudden Death Cruickshank, J., Quaas, R. L., Li, J., Hemsley, S., Gunn, T. M., & Moïse, N. S. (2009). Genetic Analysis of Ventricular Arrhythmia in Young German Shepherd Dogs. Journal of Veterinary Internal Medicine, 23(2), 264–270. https://doi.org/10.1111/j.1939-1676.2009.0265.x
Jesty, S. A., Jung, S. W., Cordeiro, J. M., Gunn, T. M., Di Diego, J. M., Hemsley, S., … Moïse, N. S. (2013). Cardiomyocyte calcium cycling in a naturally occurring German Shepherd Dog model of inherited ventricular arrhythmia and sudden cardiac death. Journal of Veterinary Cardiology, 15(1), 5–14. https://doi.org/10.1016/j.jvc.2012.07.005
Liu, W., Hackett, S. R., Cruickshank, J., Vikstrom, K. L., Moise, N. S., & Gunn, T. M. (2006). Canine microsatellites associated with genes implicated in cardiac development and function. Animal Genetics, 37(1), 87–88. https://doi.org/10.1111/j.1365-2052.2005.01410.x
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Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
