Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01701-A Research Program Area: Immunology and Infectious Disease |
Determining the Effect of Pain Medication on Immune Function: Part 1 DeClue, A. E., Yu, D.-H., Prochnow, S., Axiak-Bechtel, S., Amorim, J., Tsuruta, K., … Dodam, J. (2014). Effects of opioids on phagocytic function, oxidative burst capacity, cytokine production and apoptosis in canine leukocytes. The Veterinary Journal, 200(2), 270–275. https://doi.org/10.1016/j.tvjl.2014.02.019 |
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Grant Number: 01352-A Research Program Area: Immunology and Infectious Disease |
Detection of Brucella canis DNA in canine urine, semen and vaginal cells via qPCR Analysis Kauffman, L. K., Bjork, J. K., Gallup, J. M., Boggiatto, P. M., Bellaire, B. H., & Petersen, C. A. (2014). Early detection of Brucella canis via quantitative polymerase chain reaction analysis. Zoonoses and Public Health, 61(1), 48–54. https://doi.org/10.1111/zph.12041 |
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Grant Number: 323 Research Program Area: Neurology |
Mapping the Gene Responsible for Hypomyelination in Weimaraner Dogs Pemberton, T. J., Choi, S., Mayer, J. A., Li, F.-Y., Gokey, N., Svaren, J., … Duncan, I. D. (2014). A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination: A Mutation in FNIP2 Disrupts Myelination. Glia, 62(1), 39–51. https://doi.org/10.1002/glia.22582 |
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Grant Number: 01472 Research Program Area: Oncology |
Enhanced Killing of Malignant Histiocytosis with a Novel Combination of Anti-Tumor Drugs Hafeman, S. D., Varland, D., & Dow, S. W. (2012). Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Veterinary and Comparative Oncology, 10(1), 44–56. https://doi.org/10.1111/j.1476-5829.2011.00274.x
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Grant Number: 407 Research Program Area: Neurology |
The Genetics of Canine Cerebellar Degeneration Agler, C., Nielsen, D. M., Urkasemsin, G., Singleton, A., Tonomura, N., Sigurdsson, S., … Olby, N. J. (2014). Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24. PLoS Genetics, 10(2), e1003991. https://doi.org/10.1371/journal.pgen.1003991 |
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Grant Number: 00841-A Research Program Area: Oncology |
Pharmacokinetics and Phase I Clinical Trial of High-Dose Intermittent Oral Artemisinin in Dogs with Spontaneous Tumors Hosoya, K., Couto, C. G., London, C. A., Kisseberth, W. C., Phelps, M. A., & Dalton, J. T. (2014). Comparison of High-Dose Intermittent and Low-Dose Continuous Oral Artemisinin in Dogs With Naturally Occurring Tumors. Journal of the American Animal Hospital Association, 50(6), 390–395. https://doi.org/10.5326/JAAHA-MS-6145 |
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Grant Number: 01529-A Research Program Area: Cardiology |
Platelet, myocardial, and valvular serotonin concentrations in healthy dogs and dogs with mitral valve disease Cremer, S. E., Singletary, G. E., Olsen, L. H., Wallace, K., Häggström, J., Ljungvall, I., … Oyama, M. A. (2014). Serotonin Concentrations in Platelets, Plasma, Mitral Valve Leaflet, and Left Ventricular Myocardial Tissue in Dogs with Myxomatous Mitral Valve Disease. Journal of Veterinary Internal Medicine, 28(5), 1534–1540. https://doi.org/10.1111/jvim.12420 |
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Grant Number: 01753 Research Program Area: Cardiology |
Identification of Genetic Factors That Alter the Severity of Cardiomyopathy Meurs, K. M., Stern, J. A., Reina-Doreste, Y., Spier, A. W., Koplitz, S. L., & Baumwart, R. D. (2014). Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study. Journal of Veterinary Internal Medicine, 28(4), 1214–1220. https://doi.org/10.1111/jvim.12385 |
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Grant Number: 00970 Research Program Area: General Canine Health |
Tissue Regeneration Using Canine Mesenchymal Stem Cells: Effects of Donor Characteristics and ex vivo Expansion on Cell Pluripotency Volk, S. W., & Theoret, C. (2013). Translating stem cell therapies: The role of companion animals in regenerative medicine. Wound Repair and Regeneration, 21(3), 382–394. https://doi.org/10.1111/wrr.12044 Volk, S. W., Wang, Y., & Hankenson, K. D. (2012). Effects of Donor Characteristics and Ex Vivo Expansion on Canine Mesenchymal Stem Cell Properties: Implications for MSC-Based Therapies. Cell Transplantation, 21(10), 2189–2200. https://doi.org/10.3727/096368912X636821 |
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Grant Number: 1272 Research Program Area: General Canine Health |
Isolation and Characterization of Canine Induced Pluripotential Stem Cells (iPS)
Koh, S., Thomas, R., Tsai, S., Bischoff, S., Lim, J.-H., Breen, M., … Piedrahita, J. A. (2013). Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts. Stem Cells and Development, 22(6), 951–963. https://doi.org/10.1089/scd.2012.0393 |
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Grant Number: 934 Research Program Area: Neurology |
Investigation of Inherited Diseases of the German Shepherd Dog Using the SNP Array Tsai, K. L., Noorai, R. E., Starr-Moss, A. N., Quignon, P., Rinz, C. J., Ostrander, E. A., … Clark, L. A. (2012). Genome-wide association studies for multiple diseases of the German Shepherd Dog. Mammalian Genome, 23(1–2), 203–211. https://doi.org/10.1007/s00335-011-9376-9
Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y
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Grant Number: 00947A Research Program Area: Oncology |
Heritable and Sporadic Genetic Lesions in Canine Osteosarcoma Angstadt, A. Y., Motsinger-Reif, A., Thomas, R., Kisseberth, W. C., Guillermo Couto, C., Duval, D. L., … Breen, M. (2011). Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: Signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart. Genes, Chromosomes and Cancer, 50(11), 859–874. https://doi.org/10.1002/gcc.20908
Angstadt, A. Y., Thayanithy, V., Subramanian, S., Modiano, J. F., & Breen, M. (2012). A genome-wide approach to comparative oncology: High-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. Cancer Genetics, 205(11), 572–587. https://doi.org/10.1016/j.cancergen.2012.09.005
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A.-M., Hogendoorn, P. C., Modiano, J. F., & Subramanian, S. (2013). MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. Orphanet Journal of Rare Diseases, 8(1), 7. https://doi.org/10.1186/1750-1172-8-7
Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., … Modiano, J. F. (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone, 49(3), 356–367. https://doi.org/10.1016/j.bone.2011.05.008 |
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Grant Number: 00613 Research Program Area: Oncology - Lymphoma |
The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma Seiser, E. L., Thomas, R., Richards, K. L., Kathryn Kelley, M., Moore, P., Suter, S. E., & Breen, M. (2013). Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines. Veterinary and Comparative Oncology, 11(1), 30–50. https://doi.org/10.1111/j.1476-5829.2011.00299.x Thomas, R., Seiser, E. L., Motsinger-Reif, A., Borst, L., Valli, V. E., Kelley, K., … Breen, M. (2011). Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leukemia & Lymphoma, 52(7), 1321–1335. https://doi.org/10.3109/10428194.2011.559802 |
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Grant Number: 01531-A Research Program Area: Immunology and Infectious Disease |
Potential Role of Pericytes in Bartonella-induced Vasoproliferation Varanat, M., Maggi, R. G., Linder, K. E., & Breitschwerdt, E. B. (2013). Infection of human brain vascular pericytes (HBVPs) by Bartonella henselae. Medical Microbiology and Immunology, 202(2), 143–151. https://doi.org/10.1007/s00430-012-0279-5 |
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Grant Number: 00768 Research Program Area: Oncology - Lymphoma |
A Collaborative Study by Veterinary Oncologists, Pathologists and Diagnostic Laboratories to Enhance the Detection, Diagnosis and Treatment of Canine Lymphoma Valli, V. E., Kass, P. H., Myint, M. S., & Scott, F. (2013). Canine Lymphomas: Association of Classification Type, Disease Stage, Tumor Subtype, Mitotic Rate, and Treatment With Survival. Veterinary Pathology, 50(5), 738–748. https://doi.org/10.1177/0300985813478210 Valli, V. E., Myint, M. S., Barthel, A., Bienzle, D., Caswell, J., Colbatzky, F., … Vernau, W. (2011). Classification of Canine Malignant Lymphomas According to the World Health Organization Criteria. Veterinary Pathology, 48(1), 198–211. https://doi.org/10.1177/0300985810379428 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
