Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02081-A Research Program Area: Oncology - Hemangiosarcoma |
Integrating Cutting Edge Science with Scientific Training to Defeat Hemangiosarcoma Rodriguez, A. M., Graef, A. J., LeVine, D. N., Cohen, I. R., Modiano, J. F., & Kim, J.-H. (2015). Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma. Journal of Veterinary Internal Medicine, 29(4), 1088–1097. https://doi.org/10.1111/jvim.13570
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Grant Number: 00593A Research Program Area: Oncology - Hemangiosarcoma |
Mapping Genes Associated with Canine Hemangiosarcoma Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 |
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Grant Number: 01840 Research Program Area: Reproductive Conditions |
Health Implications of Early Spay/Neuter on Canine Health Hart, B.L., L.A. Hart, A.P. Thigpen and N. H. Willits. 2014. Long-term health effects of neutering dogs: Comparison of Labrador Retrievers and Golden Retrievers. PLoS ONE 9(7): 10.1371/journal.pone.0102241. |
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Grant Number: 954 Research Program Area: Neurology |
Identification of Genes Causing Chiari I Malformation with Syringomelia in the Cavalier King Charles Spaniel Lemay, P., Knowler, S. P., Bouasker, S., Nédélec, Y., Platt, S., Freeman, C., … Kibar, Z. (2014). Quantitative Trait Loci (QTL) Study Identifies Novel Genomic Regions Associated to Chiari-Like Malformation in Griffon Bruxellois Dogs. PLoS ONE, 9(4), e89816. https://doi.org/10.1371/journal.pone.0089816 |
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Grant Number: 01651 Research Program Area: Oncology - Lymphoma |
Serum Antibody Reactivity Profiling for Canine Lymphoma Detection and Monitoring Johnston, S. A., Thamm, D. H., & Legutki, J. B. (2014). The immunosignature of canine lymphoma: characterization and diagnostic application. BMC Cancer, 14(1). https://doi.org/10.1186/1471-2407-14-657
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Grant Number: 580 Research Program Area: Musculoskeletal Conditions and Disease |
Patella Luxation in Dogs: A Molecular Approach Lavrijsen, I. C. M., Heuven, H. C. M., Breur, G. J., Leegwater, P. A. J., Meutstege, F. J., & Hazewinkel, H. A. W. (2013). Phenotypic and genetic trends of patellar luxation in Dutch Flat-Coated Retrievers. Animal Genetics, 44(6), 736–741. https://doi.org/10.1111/age.12077
Lavrijsen, Ineke C M, Leegwater, P. A. J., Wangdee, C., van Steenbeek, F. G., Schwencke, M., Breur, G. J., … Hazewinkel, H. A. W. (2014). Genome-wide survey indicates involvement of loci on canine chromosomes 7 and 31 in patellar luxation in Flat-Coated Retrievers. BMC Genetics, 15(1), 64. https://doi.org/10.1186/1471-2156-15-64
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Grant Number: 01390-A Research Program Area: Immunology and Infectious Disease |
The Use of Mycophenolate in the Treatment of Primary Immune Mediated Hemolytic Anemia West, L. D., & Hart, J. R. (2014). Treatment of idiopathic immune-mediated hemolytic anemia with mycophenolate mofetil in five dogs: Mycophenolate for treatment of IMHA in dogs. Journal of Veterinary Emergency and Critical Care, 24(2), 226–231. https://doi.org/10.1111/vec.12121
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Grant Number: 01545-A Research Program Area: Oncology - Lymphoma |
Pilot Study to Assess Folate Receptor Expression in Canine High-Grade Multicentric Lymphoma Childress, M. O., Dhawan, D., Leamon, C. P., Miller, M. A., Ramos-Vara, J. A., Naughton, J. F., … Knapp, D. W. (2014). Assessment of folate receptor expression and folate uptake in multicentric lymphomas in dogs. American Journal of Veterinary Research, 75(2), 187–194. https://doi.org/10.2460/ajvr.75.2.187
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Grant Number: 1455 Research Program Area: Neurology |
Identification of Genes That Confer Risk for Inflammation of the Brain Barber, Renee M., Schatzberg, S. J., Corneveaux, J. J., Allen, A. N., Porter, B. F., Pruzin, J. J., … Huentelman, M. J. (2011). Identification of Risk Loci for Necrotizing Meningoencephalitis in Pug Dogs. Journal of Heredity, 102(Suppl_1), S40–S46. https://doi.org/10.1093/jhered/esr048
Barber, R.M., Porter, B. F., Li, Q., May, M., Claiborne, M. K., Allison, A. B., … Schatzberg, S. J. (2012). Broadly Reactive Polymerase Chain Reaction for Pathogen Detection in Canine Granulomatous Meningoencephalomyelitis and Necrotizing Meningoencephalitis. Journal of Veterinary Internal Medicine, 26(4), 962–968. https://doi.org/10.1111/j.1939-1676.2012.00954.x
Schrauwen, I., Barber, R. M., Schatzberg, S. J., Siniard, A. L., Corneveaux, J. J., Porter, B. F., … Huentelman, M. J. (2014). Identification of Novel Genetic Risk Loci in Maltese Dogs with Necrotizing Meningoencephalitis and Evidence of a Shared Genetic Risk across Toy Dog Breeds. PLoS ONE, 9(11), e112755. https://doi.org/10.1371/journal.pone.0112755 |
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Grant Number: 01159-A Research Program Area: Immunology and Infectious Disease |
Detection of Brucellosis canis DNA in Canine Blood Via qPCR Analysis Kauffman, L. K., Bjork, J. K., Gallup, J. M., Boggiatto, P. M., Bellaire, B. H., & Petersen, C. A. (2014). Early detection of Brucella canis via quantitative polymerase chain reaction analysis. Zoonoses and Public Health, 61(1), 48–54. https://doi.org/10.1111/zph.12041
Petersen, C. A. (2009). New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown. Interdisciplinary Perspectives on Infectious Diseases, 2009, 1–5. https://doi.org/10.1155/2009/802712
Petersen, C. A., & Barr, S. C. (2009). Canine Leishmaniasis in North America: Emerging or Newly Recognized? Veterinary Clinics of North America: Small Animal Practice, 39(6), 1065–1074. https://doi.org/10.1016/j.cvsm.2009.06.008 |
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Grant Number: 01064-A Research Program Area: Oncology |
Immunocytochemical Detection and siRNA-Mediated Knockdown of Survivin in Canine Lymphoma Shoeneman, J. K., Ehrhart, E. J., Charles, J. B., & Thamm, D. H. (2014). Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma. Veterinary and Comparative Oncology, 14(2), e45–e57. https://doi.org/10.1111/vco.12104 Shoeneman, J. K., Ehrhart, E. J., Eickhoff, J. C., Charles, J. B., Powers, B. E., & Thamm, D. H. (2012). Expression and Function of Survivin in Canine Osteosarcoma. Cancer Research, 72(1), 249–259. https://doi.org/10.1158/0008-5472.CAN-11-2315 |
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Grant Number: 01480 Research Program Area: Immunology and Infectious Disease |
Leptospirosis: An Emerging Health Concern for Field Trial and Hunting Dogs Hennebelle, J. H., Sykes, J. E., Carpenter, T. E., & Foley, J. (2013). Spatial and temporal patterns of Leptospira infection in dogs from northern California: 67 cases (2001–2010). Journal of the American Veterinary Medical Association, 242(7), 941–947. https://doi.org/10.2460/javma.242.7.941 Hennebelle, J. H., Sykes, J. E., & Foley, J. (2014). Risk Factors Associated with Leptospirosis in Dogs from Northern California: 2001–2010. Vector-Borne and Zoonotic Diseases, 14(10), 733–739. https://doi.org/10.1089/vbz.2014.1624 |
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Grant Number: 01569 Research Program Area: Oncology - Lymphoma |
Evaluation of a Novel Drug to Treat Canine Cutaneous Lymphoma Morges, M. A., Burton, J. H., Saba, C. F., Vail, D. M., Burgess, K. E., & Thamm, D. H. (2014). Phase II Evaluation of VDC-1101 in Canine Cutaneous T-Cell Lymphoma. Journal of Veterinary Internal Medicine, 28(5), 1569–1574. https://doi.org/10.1111/jvim.12429
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Grant Number: 925 Research Program Area: Neurology |
Identification of Mutations Causing Hereditary Cerebellar Cortical Degeneration in American Staffordshire Terriers and Old English Sheepdogs Abitbol, M., Thibaud, J.-L., Olby, N. J., Hitte, C., Puech, J.-P., Maurer, M., … Tiret, L. (2010). A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis. Proceedings of the National Academy of Sciences, 107(33), 14775–14780. https://doi.org/10.1073/pnas.0914206107
Agler, C., Nielsen, D. M., Urkasemsin, G., Singleton, A., Tonomura, N., Sigurdsson, S., … Olby, N. J. (2014). Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24. PLoS Genetics, 10(2), e1003991. https://doi.org/10.1371/journal.pgen.1003991 |
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Grant Number: 01248 Research Program Area: Reproductive Conditions |
Whole Genome Association Analyses for Cryptorchidism in Dogs Zhao, X., Onteru, S., Saatchi, M., Garrick, D., & Rothschild, M. (2014). A genome-wide association study for canine cryptorchidism in Siberian Huskies. Journal of Animal Breeding and Genetics, 131(3), 202–209. https://doi.org/10.1111/jbg.12064 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
