Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01190-A Research Program Area: Neurology |
Frequency of the Exercise-Induced Collapse Gene in Diverse Breeds Furrow, E., Minor, K. M., Taylor, S. M., Mickelson, J. R., & Patterson, E. E. (2013). Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. Journal of the American Veterinary Medical Association, 242(6), 786–791. https://doi.org/10.2460/javma.242.6.786
Minor, K. M., Patterson, E. E., Keating, M. K., Gross, S. D., Ekenstedt, K. J., Taylor, S. M., & Mickelson, J. R. (2011). Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador Retrievers and other breeds. The Veterinary Journal, 189(2), 214–219. https://doi.org/10.1016/j.tvjl.2011.06.022
Patterson, E. E., Minor, K. M., Tchernatynskaia, A. V., Taylor, S. M., Shelton, G. D., Ekenstedt, K. J., & Mickelson, J. R. (2008). A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nature Genetics, 40(10), 1235–1239. https://doi.org/10.1038/ng.224 |
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Grant Number: 0002254A Research Program Area: Oncology |
Heritable and Sporadic Genetic Lesions in Canine Lymphoma and Osteosarcoma Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., … Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Veterinary Pathology, 42(5), 618–632. https://doi.org/10.1354/vp.42-5-618 Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467 Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … Modiano, J. F. (2013). Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma. Veterinary Pathology, 50(4), 693–703. https://doi.org/10.1177/0300985812465325 Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., Fosmire, S. P., Coffey, D., … Modiano, J. F. (2005). CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Veterinary Pathology, 42(4), 468–476. https://doi.org/10.1354/vp.42-4-468 Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132 Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613 Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A.-M., Hogendoorn, P. C., Modiano, J. F., & Subramanian, S. (2013). MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. Orphanet Journal of Rare Diseases, 8(1), 7. https://doi.org/10.1186/1750-1172-8-7 Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., … Modiano, J. F. (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone, 49(3), 356–367. https://doi.org/10.1016/j.bone.2011.05.008 Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., … Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619 Thayanithy, V., Park, C., Sarver, A. L., Kartha, R. V., Korpela, D. M., Graef, A. J., … Subramanian, S. (2012). Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines. PLoS ONE, 7(9), e43720. https://doi.org/10.1371/journal.pone.0043720 Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., … Subramanian, S. (2012). Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. Bone, 50(1), 171–181. https://doi.org/10.1016/j.bone.2011.10.012 Thomas, R., Wang, H. J., Tsai, P.-C., Langford, C. F., Fosmire, S. P., Jubala, C. M., … Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research, 17(3), 365–377. https://doi.org/10.1007/s10577-009-9028-z |
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Grant Number: 1485 Research Program Area: Gastrointestinal Disease |
Study of PLE/PLN (Protein-losing Enteropathy/Nephropathy) in Soft-Coated Wheaten Terriers Littman, M. P., Wiley, C. A., Raducha, M. G., & Henthorn, P. S. (2013). Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mammalian Genome, 24(3–4), 119–126. https://doi.org/10.1007/s00335-012-9445-8
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Grant Number: 00779 Research Program Area: Reproductive Conditions |
Characterization of the Canine Y Chromosome: Identifying Genes that Cause Male Infertility Li, G., Davis, B. W., Raudsepp, T., Pearks Wilkerson, A. J., Mason, V. C., Ferguson-Smith, M., … Murphy, W. J. (2013). Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution. Genome Research, 23(9), 1486–1495. https://doi.org/10.1101/gr.154286.112 |
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Grant Number: 01105 Research Program Area: Immunology and Infectious Disease |
Understanding the Dynamics of Canine Influenza Virus Transmission in Dog Populations and Intervention Strategies for Reducing Transmission Anderson, T. C., Crawford, P. C., Dubovi, E. J., Gibbs, E. P. J., & Hernandez, J. A. (2013). Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with influenza-like illness in the United States. Journal of the American Veterinary Medical Association, 242(2), 209–216. https://doi.org/10.2460/javma.242.2.209
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Grant Number: 1262 Research Program Area: Reproductive Conditions |
Sequencing and Functional Analysis of the Canine Y Chromosome Li, G., Davis, B. W., Raudsepp, T., Pearks Wilkerson, A. J., Mason, V. C., Ferguson-Smith, M., … Murphy, W. J. (2013). Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution. Genome Research, 23(9), 1486–1495. https://doi.org/10.1101/gr.154286.112 |
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Grant Number: 01490-A Research Program Area: Oncology - Lymphoma |
Evaluation of Aurora kinase inhibitors in canine lymphoma in vitro Shiomitsu, K., Xia, X., Waite, K., Sehgal, I., & Li, S. (2013). Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in vitro. Open Journal of Veterinary Medicine, 03(01), 29–38. https://doi.org/10.4236/ojvm.2013.31006 |
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Grant Number: 01012-A Research Program Area: Ophthalmology |
Genetic Studies in Chronic Superficial Keratitis in German Shepherd Dogs Barrientos, L. S., Zapata, G., Crespi, J. A., Posik, D. M., Díaz, S., It, V., … Giovambattista, G. (2013). A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1. Veterinary Immunology and Immunopathology, 156(3–4), 205–210. https://doi.org/10.1016/j.vetimm.2013.10.009
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Grant Number: 2219 Research Program Area: Gastrointestinal Disease |
Longitudinal Clinical Study, Mode of Inheritance and Therapeutic Trial of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers Allenspach, K., Vaden, S. L., Harris, T. S., Gröne, A., Doherr, M. G., Griot-Wenk, M. E., … Gaschen, F. (2006). Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions. Journal of Small Animal Practice, 47(1), 21–26. https://doi.org/10.1111/j.1748-5827.2006.00007.x
Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027 |
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Grant Number: 1285 Research Program Area: Gastrointestinal Disease |
Mode of Inheritance and Method for Early Detection of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027 |
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Grant Number: 01317 Research Program Area: Oncology - Osteosarcoma |
Mutation Detection and Functional Analysis of Multiple Loci for Osteosarcoma Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
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Grant Number: 0002254B Research Program Area: Oncology |
Heritable and Sporadic Genetic Lesions in Canine Lymphoma and Osteosarcoma Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., … Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Veterinary Pathology, 42(5), 618–632. https://doi.org/10.1354/vp.42-5-618
Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467
Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … Modiano, J. F. (2013). Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma. Veterinary Pathology, 50(4), 693–703. https://doi.org/10.1177/0300985812465325
Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., Fosmire, S. P., Coffey, D., … Modiano, J. F. (2005). CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Veterinary Pathology, 42(4), 468–476. https://doi.org/10.1354/vp.42-4-468
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613
Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A.-M., Hogendoorn, P. C., Modiano, J. F., & Subramanian, S. (2013). MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. Orphanet Journal of Rare Diseases, 8(1), 7. https://doi.org/10.1186/1750-1172-8-7
Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., … Modiano, J. F. (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone, 49(3), 356–367. https://doi.org/10.1016/j.bone.2011.05.008
Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., … Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619
Thayanithy, V., Park, C., Sarver, A. L., Kartha, R. V., Korpela, D. M., Graef, A. J., … Subramanian, S. (2012). Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines. PLoS ONE, 7(9), e43720. https://doi.org/10.1371/journal.pone.0043720
Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., … Subramanian, S. (2012). Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. Bone, 50(1), 171–181. https://doi.org/10.1016/j.bone.2011.10.012
Thomas, R., Wang, H. J., Tsai, P.-C., Langford, C. F., Fosmire, S. P., Jubala, C. M., … Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research, 17(3), 365–377. https://doi.org/10.1007/s10577-009-9028-z |
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Grant Number: 01113 Research Program Area: Oncology - Lymphoma |
Canine Non-Hodgkin Lymphoma: Characterization and Prognostic Value of Cancer Stem Cells Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … Modiano, J. F. (2013). Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma. Veterinary Pathology, 50(4), 693–703. https://doi.org/10.1177/0300985812465325 Ito, D., Endicott, M. M., Jubala, C. M., Helm, K. M., Burnett, R. C., Husbands, B. D., … Modiano, J. F. (2011). A Tumor-Related Lymphoid Progenitor Population Supports Hierarchical Tumor Organization in Canine B-Cell Lymphoma: Canine B-Cell Lymphoma. Journal of Veterinary Internal Medicine, 25(4), 890–896. https://doi.org/10.1111/j.1939-1676.2011.0756.x Ito, Daisuke, Frantz, A. M., Williams, C., Thomas, R., Burnett, R. C., Avery, A. C., … Modiano, J. F. (2012). CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies. Leukemia & Lymphoma, 53(7), 1390–1398. https://doi.org/10.3109/10428194.2011.654337 Ito, Daisuke, O’Brien, T. D., & Modiano, J. F. (2010). Exclusion of cytoplasmic fragments in flow cytometric analysis of lymph node samples from dogs with lymphoma using membrane-permeable violet laser-excitable DNA-binding fluorescent dye (DyeCycle Violet). Veterinary Clinical Pathology, 39(4), 494–498. https://doi.org/10.1111/j.1939-165X.2010.00252.x Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368 |
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Grant Number: 1873 Research Program Area: Gastrointestinal Disease |
Sequential Clinical Evaluation, Mode of Inheritance, and Therapeutic Trial of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers Vaden, S. L., Hammerberg, B., Davenport, D. J., Orton, S. M., Trogdon, M. M., Melgarejo, L. T., … Williams, D. A. (2000). Food Hypersensitivity Reactions in Soft Coated Wheaten Terriers with Protein-Losing Enteropathy or Protein-Losing Nephropathy or Both: Gastroscopic Food Sensitivity Testing, Dietary Provocation, and Fecal Immunoglobulin E. Journal of Veterinary Internal Medicine, 14, 60–67.
Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027
Vaden, S. L., Sellon, R. K., Melgarejo, L. T., Williams, D. A., Trogdon, M. M., VanCamp, S. D., & Argenzio, R. A. (2000). Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both. American Journal of Veterinary Research, 61(5), 518–524. https://doi.org/10.2460/ajvr.2000.61.518 |
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Grant Number: 01855-A Research Program Area: Gastrointestinal Disease |
Improving Diagnosis and Treatment of Inflammatory Bowel Disease Prakash, N., Stumbles, P., & Mansfield, C. (2013). Initial Validation of Cytokine Measurement by ELISA in Canine Feces. Open Journal of Veterinary Medicine, 03(06), 282–288. https://doi.org/10.4236/ojvm.2013.36046 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
