Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 00373A Research Program Area: Oncology - Osteosarcoma |
Mapping Genes Associated with Osteosarcoma in Large Dog Breeds Karlsson, E. K., Baranowska, I., Wade, C. M., Salmon Hillbertz, N. H. C., Zody, M. C., Anderson, N., … Lindblad-Toh, K. (2007). Efficient mapping of mendelian traits in dogs through genome-wide association. Nature Genetics, 39(11), 1321–1328. https://doi.org/10.1038/ng.2007.10 Karlsson, E. K., & Lindblad-Toh, K. (2008). Leader of the pack: Gene mapping in dogs and other model organisms. Nature Reviews Genetics, 9(9), 713–725.https://doi.org/10.1038/nrg2382 Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132 Salmon Hillbertz, N. H. C., Isaksson, M., Karlsson, E. K., Hellmén, E., Pielberg, G. R., Savolainen, P., … Andersson, G. (2007). Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback Dogs. Nature Genetics, 39(11), 1318–1320.https://doi.org/10.1038/ng.2007.4 |
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Grant Number: 00978-A Research Program Area: Oncology |
Isolation of the Canine Telomerase Reverse Transcriptase (TERT) Subunit and Generation of Dominant-Negative Mutants for Telomerase Inhibition Milne, M. E., Anderson, G. A., Chow, K. E., O’Brien, T. J., Moffat, B. A., & Long, S. N. (2013). Description of technique and lower reference limit for magnetic resonance imaging of hippocampal volumetry in dogs. American Journal of Veterinary Research, 74(2), 224–231. https://doi.org/10.2460/ajvr.74.2.224 |
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Grant Number: 01535-A Research Program Area: Kidney & Urological Disease |
DNA Sequence Examination of a Gene Region Associated with Mastiff Cystine Stone Formation Brons, A.-K., Henthorn, P. S., Raj, K., Fitzgerald, C. A., Liu, J., Sewell, A. C., & Giger, U. (2013). SLC3A1 and SLC7A9 Mutations in Autosomal Recessive or Dominant Canine Cystinuria: A New Classification System. Journal of Veterinary Internal Medicine, 27(6), 1400–1408. https://doi.org/10.1111/jvim.12176
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Grant Number: 01497-A Research Program Area: Oncology - Lymphoma |
Dog leukocyte antigen 88 typing in German Shepherd Dogs having pancreatic insufficiency Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y |
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Grant Number: 01052-A Research Program Area: Oncology |
Whole Genome Association Mapping of Squamous Cell Carcinoma (SCC) of the Digit in the Standard Poodle Karyadi, D. M., Karlins, E., Decker, B., vonHoldt, B. M., Carpintero-Ramirez, G., Parker, H. G., … Ostrander, E. A. (2013). A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit. PLoS Genetics, 9(3), e1003409. https://doi.org/10.1371/journal.pgen.1003409 |
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Grant Number: 01113 Research Program Area: Oncology - Lymphoma |
Canine Non-Hodgkin Lymphoma: Characterization and Prognostic Value of Cancer Stem Cells Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., … Modiano, J. F. (2013). Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma. Veterinary Pathology, 50(4), 693–703. https://doi.org/10.1177/0300985812465325 Ito, D., Endicott, M. M., Jubala, C. M., Helm, K. M., Burnett, R. C., Husbands, B. D., … Modiano, J. F. (2011). A Tumor-Related Lymphoid Progenitor Population Supports Hierarchical Tumor Organization in Canine B-Cell Lymphoma: Canine B-Cell Lymphoma. Journal of Veterinary Internal Medicine, 25(4), 890–896. https://doi.org/10.1111/j.1939-1676.2011.0756.x Ito, Daisuke, Frantz, A. M., Williams, C., Thomas, R., Burnett, R. C., Avery, A. C., … Modiano, J. F. (2012). CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies. Leukemia & Lymphoma, 53(7), 1390–1398. https://doi.org/10.3109/10428194.2011.654337 Ito, Daisuke, O’Brien, T. D., & Modiano, J. F. (2010). Exclusion of cytoplasmic fragments in flow cytometric analysis of lymph node samples from dogs with lymphoma using membrane-permeable violet laser-excitable DNA-binding fluorescent dye (DyeCycle Violet). Veterinary Clinical Pathology, 39(4), 494–498. https://doi.org/10.1111/j.1939-165X.2010.00252.x Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368 |
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Grant Number: 1873 Research Program Area: Gastrointestinal Disease |
Sequential Clinical Evaluation, Mode of Inheritance, and Therapeutic Trial of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers Vaden, S. L., Hammerberg, B., Davenport, D. J., Orton, S. M., Trogdon, M. M., Melgarejo, L. T., … Williams, D. A. (2000). Food Hypersensitivity Reactions in Soft Coated Wheaten Terriers with Protein-Losing Enteropathy or Protein-Losing Nephropathy or Both: Gastroscopic Food Sensitivity Testing, Dietary Provocation, and Fecal Immunoglobulin E. Journal of Veterinary Internal Medicine, 14, 60–67.
Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027
Vaden, S. L., Sellon, R. K., Melgarejo, L. T., Williams, D. A., Trogdon, M. M., VanCamp, S. D., & Argenzio, R. A. (2000). Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both. American Journal of Veterinary Research, 61(5), 518–524. https://doi.org/10.2460/ajvr.2000.61.518 |
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Grant Number: 01855-A Research Program Area: Gastrointestinal Disease |
Improving Diagnosis and Treatment of Inflammatory Bowel Disease Prakash, N., Stumbles, P., & Mansfield, C. (2013). Initial Validation of Cytokine Measurement by ELISA in Canine Feces. Open Journal of Veterinary Medicine, 03(06), 282–288. https://doi.org/10.4236/ojvm.2013.36046 |
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Grant Number: 01876-A Research Program Area: Oncology |
Ensuring That Emerging Stem Cell Treatments Do Not Activate or Exacerbate Cancer in Dogs Volk, S. W., & Theoret, C. (2013). Translating stem cell therapies: The role of companion animals in regenerative medicine: Stem cell therapies in veterinary medicine. Wound Repair and Regeneration, 21(3), 382–394. https://doi.org/10.1111/wrr.12044 |
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Grant Number: 01194-A Research Program Area: Oncology |
Role of Hypoxia-Related Factors in Dog Glioblastoma Invasion Stoica, G., Levine, J., Wolff, J., & Murphy, K. (2011). Canine Astrocytic Tumors: A Comparative Review. Veterinary Pathology, 48(1), 266–275. https://doi.org/10.1177/0300985810389543
Stoica, G., Lungu, G., Martini-STOICA, H., Waghela, S., Levine, J., & Smith, R. (2009). Identification of Cancer Stem Cells in Dog Glioblastoma. Veterinary Pathology, 46(3), 391–406. https://doi.org/10.1354/vp.08-VP-0218-S-FL |
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Grant Number: 00757A Research Program Area: Oncology - Osteosarcoma |
Hereditary Mutations in Genes Associated with Osteosarcoma in Large Dog Breeds Karlsson, E. K., Baranowska, I., Wade, C. M., Salmon Hillbertz, N. H. C., Zody, M. C., Anderson, N., … Lindblad-Toh, K. (2007). Efficient mapping of mendelian traits in dogs through genome-wide association. Nature Genetics, 39(11), 1321–1328. https://doi.org/10.1038/ng.2007.10
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
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Grant Number: 01105 Research Program Area: Immunology and Infectious Disease |
Understanding the Dynamics of Canine Influenza Virus Transmission in Dog Populations and Intervention Strategies for Reducing Transmission Anderson, T. C., Crawford, P. C., Dubovi, E. J., Gibbs, E. P. J., & Hernandez, J. A. (2013). Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with influenza-like illness in the United States. Journal of the American Veterinary Medical Association, 242(2), 209–216. https://doi.org/10.2460/javma.242.2.209
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Grant Number: 1262 Research Program Area: Reproductive Conditions |
Sequencing and Functional Analysis of the Canine Y Chromosome Li, G., Davis, B. W., Raudsepp, T., Pearks Wilkerson, A. J., Mason, V. C., Ferguson-Smith, M., … Murphy, W. J. (2013). Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution. Genome Research, 23(9), 1486–1495. https://doi.org/10.1101/gr.154286.112 |
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Grant Number: 01490-A Research Program Area: Oncology - Lymphoma |
Evaluation of Aurora kinase inhibitors in canine lymphoma in vitro Shiomitsu, K., Xia, X., Waite, K., Sehgal, I., & Li, S. (2013). Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in vitro. Open Journal of Veterinary Medicine, 03(01), 29–38. https://doi.org/10.4236/ojvm.2013.31006 |
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Grant Number: 01012-A Research Program Area: Ophthalmology |
Genetic Studies in Chronic Superficial Keratitis in German Shepherd Dogs Barrientos, L. S., Zapata, G., Crespi, J. A., Posik, D. M., Díaz, S., It, V., … Giovambattista, G. (2013). A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1. Veterinary Immunology and Immunopathology, 156(3–4), 205–210. https://doi.org/10.1016/j.vetimm.2013.10.009
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Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
