Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01718-A Research Program Area: Musculoskeletal Conditions and Disease |
Preventing Osteoarthritis after Elbow Dysplasia Surgery McConkey, M. J., Valenzano, D. M., Wei, A., Li, T., Thompson, M. S., Mohammed, H. O., … Krotscheck, U. (2016). Effect of the Proximal Abducting Ulnar Osteotomy on Intra-Articular Pressure Distribution and Contact Mechanics of Congruent and Incongruent Canine Elbows Ex Vivo. Veterinary Surgery, 45(3), 347–355. https://doi.org/10.1111/vsu.12456 |
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Grant Number: 00993-A Research Program Area: Neurology |
Dynactin Mutations in Canine Idiopathic Laryngeal Paralysis Holt, D. E., Brown, D. C., & Henthorn, P. S. (2016). Evaluation of the dynactin 1 gene in Leonbergers and Labrador Retrievers with laryngeal paralysis. American Journal of Veterinary Research, 77(10), 1114–1120. https://doi.org/10.2460/ajvr.77.10.1114 |
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Grant Number: 01511-A Research Program Area: Neurology |
Basis of Exercise-Induced Border Collie Collapse Taylor, S., Minor, K., Shmon, C. L., Shelton, G. D., Patterson, E. E., & Mickelson, J. R. (2016). Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. Journal of the American Animal Hospital Association, 52(6), 364–370. http://doi.org/10.5326/JAAHA-MS-6436 |
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Grant Number: 1718 Research Program Area: Epilepsy Initiative |
Molecular Genetic Basis of Epilepsy in Standard Schnauzers and English Springer Spaniels McConkey, M. J., Valenzano, D. M., Wei, A., Li, T., Thompson, M. S., Mohammed, H. O., … Krotscheck, U. (2016). Effect of the Proximal Abducting Ulnar Osteotomy on Intra-Articular Pressure Distribution and Contact Mechanics of Congruent and Incongruent Canine Elbows Ex Vivo. Veterinary Surgery, 45(3), 347–355. https://doi.org/10.1111/vsu.12456 |
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Grant Number: 01975-A Research Program Area: Neurology |
Development of a Technique to Treat Nerve and Spinal Cord Damage Through Transplantation of Cells That Support the Repair of Damaged Neurons Lim, J.-H., & Olby, N. J. (2016). Generation of pure cultures of autologous Schwann cells by use of biopsy specimens of the dorsal cutaneous branches of the cervical nerves of young adult dogs. American Journal of Veterinary Research, 77(10), 1166–1174. https://doi.org/10.2460/ajvr.77.10.1166 |
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Grant Number: 2133 Research Program Area: Epilepsy Initiative |
Canine Epilepsy: Genetic Variants, Biomarkers, and New Therapies Vuu, I., Coles, L. D., Maglalang, P., Leppik, I. E., Worrell, G., Crepeau, D., … Patterson, E. E. (2016). Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy. Frontiers in Veterinary Science. 3. https://doi.org/10.3389/fvets.2016.00107 |
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Grant Number: 01271A Research Program Area: Neurology |
Mapping of Additional Genes Associated with Canine Degenerative Myelopathy Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., … Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794–2799. https://doi.org/10.1073/pnas.0812297106
Coates, J. R., & Wininger, F. A. (2010). Canine Degenerative Myelopathy. Veterinary Clinics of North America: Small Animal Practice, 40(5), 929–950. https://doi.org/10.1016/j.cvsm.2010.05.001
Ivansson, E. L., Megquier, K., Kozyrev, S. V., Murén, E., Körberg, I. B., Swofford, R., … Lindblad-Toh, K. (2016). Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy. Proceedings of the National Academy of Sciences, 113(22), E3091–E3100. https://doi.org/10.1073/pnas.1600084113
Shelton, G. D., Johnson, G. C., O’Brien, D. P., Katz, M. L., Pesayco, J. P., Chang, B. J., … Coates, J. R. (2012). Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and Boxers. Journal of the Neurological Sciences, 318(1–2), 55–64. https://doi.org/10.1016/j.jns.2012.04.003
Wininger, F. A., Zeng, R., Johnson, G. S., Katz, M. L., Johnson, G. C., Bush, W. W., … Coates, J. R. (2011). Degenerative Myelopathy in a Bernese Mountain Dog with a Novel SOD1 Missense Mutation. Journal of Veterinary Internal Medicine, 25(5), 1166–1170. https://doi.org/10.1111/j.1939-1676.2011.0760.x
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Grant Number: 02128-A Research Program Area: Immunology and Infectious Disease |
Redefining the Recommendations for Prevention of Infectious Disease at Dog Shows and Other Areas Where Dogs Meet and Compete Stull, J. W., Kasten, J. I., Evason, M. D., Sherding, R. G., Hoet, A. E., O’Quin, J., … Weese, J. S. (2016). Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings. Journal of the American Veterinary Medical Association, 249(6), 612–627. https://doi.org/10.2460/javma.249.6.612 |
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Grant Number: 01912-A Research Program Area: Oncology |
Enhancing the Safety and Efficacy of Anti-Cancer Drugs in Dogs Ferguson, D. C., Cheng, Q., & Blanco, J. G. (2015). Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218. Drug Metabolism and Disposition, 43(7), 922–927. https://doi.org/10.1124/dmd.115.064295 Quiñones-Lombraña, A., Cheng, Q., Ferguson, D. C., & Blanco, J. G. (2016). Transcriptional regulation of the canine carbonyl reductase 1 gene ( cbr1 ) by the specificity protein 1 (Sp1). Gene, 592(1), 209–214. https://doi.org/10.1016/j.gene.2016.08.005 |
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Grant Number: 01903-A Research Program Area: Oncology - Osteosarcoma |
Defining the Anti-Tumor Activity of Monocytes in Osteosarcoma Tuohy, J. L., Lascelles, B. D. X., Griffith, E. H., & Fogle, J. E. (2016). Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function. Journal of Veterinary Internal Medicine, 30(4), 1167–1178. https://doi.org/10.1111/jvim.13983
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Grant Number: 2109 Research Program Area: Musculoskeletal Conditions and Disease |
Studying Hypertrophic Osteodystrophy (HOD) In Irish Setter Dogs Safra, N., Hitchens, P. L., Maverakis, E., Mitra, A., Korff, C., Johnson, E., … Bannasch, D. L. (2016). Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission. Veterinary Immunology and Immunopathology, 179, 32–35. https://doi.org/10.1016/j.vetimm.2016.08.003 |
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Grant Number: 01925-A Research Program Area: Oncology - Hemangiosarcoma |
Discovery of Novel Micro-Ribonucleic Acids for Diagnosis and Prognosis of Canine Hemangiosarcoma Grimes, J. A., Prasad, N., Levy, S., Cattley, R., Lindley, S., Boothe, H. W., … Smith, B. F. (2016). A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs. BMC Veterinary Research, 12(1). https://doi.org/10.1186/s12917-016-0903-5
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Grant Number: 2120 Research Program Area: Musculoskeletal Conditions and Disease |
Investigating Hypertrophic Osteodystrophy in Weimaraner Dogs Safra, N., Hitchens, P. L., Maverakis, E., Mitra, A., Korff, C., Johnson, E., … Bannasch, D. L. (2016). Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission. Veterinary Immunology and Immunopathology, 179, 32–35. https://doi.org/10.1016/j.vetimm.2016.08.003 |
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Grant Number: 02110-A Research Program Area: Kidney & Urological Disease |
Investigating the Effects of an Infusion of Fenoldopam on Kidney Function to Improve Outcomes of Acute Kidney Injury Patients Kelly, K. L., Drobatz, K. J., & Foster, J. D. (2016). Effect of Fenoldopam Continuous Infusion on Glomerular Filtration Rate and Fractional Excretion of Sodium in Healthy Dogs. Journal of Veterinary Internal Medicine, 30(5), 1655–1660. http://doi.org/10.1111/jvim.14522 |
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Grant Number: 2083-A Research Program Area: Immunology and Infectious Disease |
Stemming the Growing Epidemic of Drug Resistant Bacteria Crawford, E. C., Singh, A., Gibson, T. W. G., & Weese, J. S. (2016). Biofilm-Associated Gene Expression in Staphylococcus pseudintermedius on a Variety of Implant Materials: Biofilm Gene Expression on Implant Surfaces. Veterinary Surgery, 45(4), 499–506. https://doi.org/10.1111/vsu.12471
Crawford, E. C., Singh, A., Metcalf, D., Gibson, T. W., & Weese, S. J. (2014). Identification of appropriate reference genes for qPCR studies in Staphylococcus pseudintermedius and preliminary assessment of icaA gene expression in biofilm-embedded bacteria. BMC Research Notes, 7(1), 451. https://doi.org/10.1186/1756-0500-7-451 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
