00373A: Mapping Genes Associated with Osteosarcoma in Large Dog Breeds

Grant Status: Closed

Grant Amount: $105,592
Dr. Kerstin Lindblad-Toh, PhD, Broad Institute
January 1, 2005 - December 31, 2006
Sponsor(s): Gordon Setter Club of America, Old English Sheepdog Club of America, Scottish Terrier Club of America, Staffordshire Terrier Club of America, TarTan Gordon Setter Club
Breed(s): Newfoundland, Greyhound, Rottweiler, Saint Bernard, Borzoi, Great Pyrenees, Irish Wolfhound, Golden Retriever, Irish Setter
Research Program Area: Prevention

Abstract

Eight thousand to ten thousand cases of osteosarcoma, a malignant bone tumor, are reported in dogs in the United States annually, representing a significant health concern. In the majority of cases, spread of the tumor throughout the body and death follows within a few years. Osteosarcoma affects all dogs, but the disease frequency is considerably higher in large and giant breeds, including the long-limbed hounds (Irish Wolfhound, Great Dane, Greyhound, Scottish Deerhound, Rhodesian Ridgeback, Great Pyrenees and Borzoi) and Mastiff-type breeds (Rottweiler, Labrador Retriever, Flat-Coated Retriever, Golden Retriever, Mastiff, Bullmastiff, Saint Bernard, Irish Setter, and Newfoundland). It is clear the genetics play an important role. We propose to identify the genetic risk factors for osteosarcoma in two breeds: Greyhound and Rottweiler. While certain characteristics of these two breeds make them ideal to study, we expect that the genes identified in these breeds may also be associated with osteosarcoma in related breeds. This study should lead to the development of genetic tests for osteosarcoma that could be used to eliminate carriers from breeding populations, eventually reducing the frequency of this devastating cancer. Ultimately, it could also lead to improvements in treatment of osteosarcoma.

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