01180-A: The Prognostic Value of Various Cerebrospinal Fluid Biomarkers in Dogs with Acute Thoracolumbar Disk Herniation

Grant Status: Closed

Grant Amount: $8,293.45
Dr. Gwendolyn J. Levine, DVM, Texas A&M University
July 1, 2008 - December 31, 2009
Sponsor(s): LEAP Agility
Breed(s): -All Dogs
Research Program Area: Treatment

Project Summary

The researchers have completed project enrollment and all aspects of data analysis. It appears that CSF levels of 3 biomarkers, CK, lactate, and MBP are significantly higher in dogs with poor long-term outcome. The MBP data are particularly interesting as this biomarker appears to offer information that is independent of initial neurologic dysfunction as graded by MFS. In dogs with MRI identified changes within the spinal cord, CK concentrations are also significantly higher. These data are very promising as they may offer alternative means to predict outcome in addition to traditional physical examination-based parameters. They may also act as a means to stratify patient populations for the purposes of clinical trials.

Publication(s)

- A manuscript has been submitted to Veterinary Surgery "Cerebrospinal fluid analysis and neurologic outcome at discharge after surgical treatment of thoracolumbar disc herniation"

- A second manuscript will be submitted to the Journal of Veterina

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