01180-A: The Prognostic Value of Various Cerebrospinal Fluid Biomarkers in Dogs with Acute Thoracolumbar Disk Herniation

Grant Status: Closed

Grant Amount: $8,293
Gwendolyn J. Levine, DVM; Texas A&M University
July 1, 2008 - December 31, 2009

Sponsor(s): LEAP Agility

Breed(s): -All Dogs
Research Program Area: Neurology
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Project Summary

The researchers have completed project enrollment and all aspects of data analysis. It appears that CSF levels of 3 biomarkers, CK, lactate, and MBP are significantly higher in dogs with poor long-term outcome. The MBP data are particularly interesting as this biomarker appears to offer information that is independent of initial neurologic dysfunction as graded by MFS. In dogs with MRI identified changes within the spinal cord, CK concentrations are also significantly higher. These data are very promising as they may offer alternative means to predict outcome in addition to traditional physical examination-based parameters. They may also act as a means to stratify patient populations for the purposes of clinical trials.


Jeffery, N. D., Levine, J. M., Olby, N. J., & Stein, V. M. (2013). Intervertebral Disk Degeneration in Dogs: Consequences, Diagnosis, Treatment, and Future Directions. Journal of Veterinary Internal Medicine, 27(6), 1318–1333. https://doi.org/10.1111/jvim.12183

Levine, G. J., Levine, J. M., Witsberger, T. H., Kerwin, S. C., Russell, K. E., Suchodolski, J., … Fosgate, G. T. (2010). Cerebrospinal Fluid Myelin Basic Protein as a Prognostic Biomarker in Dogs with Thoracolumbar Intervertebral Disk Herniation. Journal of Veterinary Internal Medicine, 24(4), 890–896. https://doi.org/10.1111/j.1939-1676.2010.0531.x

Witsberger, T. H., Levine, J. M., Fosgate, G. T., Slater, M. R., Kerwin, S. C., Russell, K. E., & Levine, G. J. (2012). Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation. Journal of the American Veterinary Medical Association, 240(5), 555–562. https://doi.org/10.2460/javma.240.5.555

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