01077-A: Characterization of a P-Type ATPase, an Integral Membrane Protein in Dog Adipose Tissue: a Novel Target for Metabolic Diseases in Mammals
Grant Status: Closed
Project SummaryUsing molecular biology techniques, this pilot research study confirmed that a novel P-type ATPase, Atp10c is highly expressed in the visceral fat tissue in dogs. This project established reagents and cell culture techniques by which this gene can be studied further in dogs. Preliminary data suggests that this gene and its protein may have important roles in affecting body fat and insulin resistance in companion animals.
Publication(s)Roshwalb, S., Gorman, S., Hurst, S., Bartges, J., Agarwal, S., Sommardahl, C., Odoi, A., Dhar, M.S., 2010, mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score. The Veterinary Journal In Press, Corrected Proof.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.