2222: Molecular Control of Prostaglandin Synthesis in Canine Mammary Tumors

Grant Status: Closed

Grant Amount: $89,110
Dr. Monique Dore, DVM PhD, University of Montreal
March 20, 2002 - March 31, 2004
Sponsor(s): Mid-Kentucky Kennel Club, Nestle Purina PetCare Company, Skye Terrier Foundation
Breed(s): Skye Terrier
Research Program Area: Treatment

Abstract

Tumors originating from the mammary gland represent the most frequent form of cancer in female dogs. However, very little information is known of the mechanisms involved in the development of this cancer. In dogs, the growth of mammary gland tumors is dependent on the age of the animal and on its hormones. Malignant mammary tumors can recur following surgical excision or can send cancerous cells to distant organs. Cyclooxygenase-2, an enzyme that is essential in the production of prostaglandins, has recently been implicated in various forms of cancer in humans, including breast cancer. However, the possible implication of this enzyme in canine mammary cancer has never been addressed. The objective of this proposal is to study the mechanisms involved in the synthesis of prostaglandins in mammary tumors in the dog. We first plan to study the expression of the enzyme COX-2 in benign and malignant mammary tumors in dogs. We then want to characterize the regulation of the enzyme COX-2 in cultures of cells derived from canine mammary tumors. It is expected that a better comprehension of the mechanisms involved in COX-2 expression in canine mammary cancer will help design new strategies for cancer therapy and prevention in the canine species.

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