01495-A: Comparison of cellular function in two canine platelet concentrates

Grant Status: Closed

Grant Amount: $9,448.8
Dr. Karl E. Jandrey, DVM, University of California, Davis
July 1, 2010 - June 30, 2011
Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., Bernese Mountain Dog Club of America, Golden Retriever Foundation, Samoyed Club of America Education & Research Foundation, Schooley's Mountain Kennel Club
Breed(s): -All Dogs
Research Program Area: Treatment

Project Summary

Platelets are small cells present in blood that play a major role in clot formation in order to stop bleeding. In human medicine, platelets are transfused to patients with multiple bleeding disorders: either because they have a low number of platelets in their blood stream or because their platelets do not function properly. These conditions place them at risk for severe and uncontrolled bleeding. Platelet transfusion has recently become possible in veterinary medicine for the same indications. Fresh platelet concentrates can be produced by two different methods of centrifugation; one is favored in Europe and the other in the United States of America. Little is known about the function of canine platelets in either of these fresh platelet products. Data from human literature suggests that the preparation method influences the function of platelets. It is therefore important for the clinician to know the quality of the platelet function and the ability to form a clot in a blood product prior to administration to a patient in need. The primary goal of this study was to compare the function of platelets and to assess the sterility of the platelet concentrate from canine platelet concentrates obtained via two different methods of preparation. The two methods of preparation of platelet concentrates have been compared according to the initial description. Statistical analysis has yielded interesting information proving the overall superiority of one of the two methods. The results should both influence platelet transfusion and open new research horizons aiming to improve the care of dogs in need of platelet transfusion.

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