2131: Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy

Grant Status: Open

Grant Amount: $116,000
Dr. Sam Nicholas Long, PhD, The University of Melbourne
October 1, 2014 - September 30, 2016
Sponsor(s): Alaskan Malamute Club of America, Inc., American Belgian Tervuren Club, Inc., American Brittany Club, American Cavalier King Charles Spaniel Club Charitable Trust, American German Shepherd Dog Charitable Foundation, Inc., American Pointer Club, Australian Shepherd Health & Genetics Institute, Collie Health Foundation, English Springer Spaniel Field Trial Association Foundation, Field Spaniel Society of America, German Shorthaired Pointer Club of America, Inc., Giant Schnauzer Club of America, Gordon Setter Club of America, Inc., Greater Swiss Mountain Dog Club of America, Inc., Greyhound Club of America, Irish Water Spaniel Club of America, Keeshond Club of America, Siberian Husky Club of America, Inc., St. Bernard Club of America, Toby's Foundation, United States Australian Shepherd Association, United States Australian Shepherd Foundation
Breed(s): -All Dogs
Research Program Area: Epilepsy

Abstract

Epilepsy is a debilitating condition that affects a large number of dogs, resulting in premature death and distress for their owners. For many dogs the underlying cause is unknown. In people, advances in some types of imaging have identified subtle abnormalities, including abnormal development and shrinkage of particular regions in the brain of some people with epilepsy that can be surgically removed to improve the control of seizures. This project will apply the same advanced techniques to the brains of dogs with epilepsy to determine whether those same abnormalities exist in dogs. In those dogs in which no abnormalities can be found, this project will investigate a new form of treatment, known as neurostimulation which has been shown to reduce the frequency of seizures dramatically in human clinical trials. This involves surgically implanting a new, highly sophisticated device called the Brain Radio that can provide controlled electrical stimulation to parts of the brain while simultaneously recording the brain's activity. This device is one of the very first that could potentially provide successful therapy only when needed to treat imminent seizures and if it proves successful in dogs it will enter clinical trials in people with epilepsy.

Publication(s)

Description of technique and lower reference limit for magnetic resonance imaging of hippocampal volumetry in dogs. Milne ME, Anderson GA, Chow KE, O'Brien TJ, Moffat BA, Long SN. Am J Vet Res. 2013 Feb;74(2):224-31. doi: 10.2460/ajvr.74.2.224.

Development of representative magnetic resonance imaging-based atlases of the canine brain and evaluation of three methods for atlas-based segmentation. Milne ME, Steward C, Firestone SM, Long SN, O'Brien TJ, Moffat BA. Am J Vet Res. 2016 Apr;77(4):395-403. doi: 10.2460/ajvr.77.4.395.

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