Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01859-A Research Program Area: Cardiology |
Defining the Significance of Irregular Heartbeats through Early Monitoring Kurosawa, T. A., Sist, M. D., & Sanders, R. A. (2018). Echocardiographic variables in healthy North American Salukis. Journal of Veterinary Cardiology, 20(5), 301–306. https://doi.org/10.1016/j.jvc.2018.07.003
Sanders, R. A., Kurosawa, T. A., & Sist, M. D. (2018). Ambulatory electrocardiographic evaluation of the occurrence of arrhythmias in healthy Salukis. Journal of the American Veterinary Medical Association, 252(8), 966–969. https://doi.org/10.2460/javma.252.8.966 |
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Grant Number: 2248 Research Program Area: Neurology, Epilepsy Initiative |
Identification of a Novel Juvenile Myoclonic Epilepsy Gene and Its Underlying Disease Mechanism James, F. M. K., Cortez, M. A., Monteith, G., Jokinen, T. S., Sanders, S., Wielaender, F., … Lohi, H. (2017). Diagnostic Utility of Wireless Video-Electroencephalography in Unsedated Dogs. Journal of Veterinary Internal Medicine, 31(5), 1469–1476. https://doi.org/10.1111/jvim.14789
Wielaender, F., James, F. M. K., Cortez, M. A., Kluger, G., Neßler, J. N., Tipold, A., … Fischer, A. (2018). Absence Seizures as a Feature of Juvenile Myoclonic Epilepsy in Rhodesian Ridgeback Dogs. Journal of Veterinary Internal Medicine, 32(1), 428–432. https://doi.org/10.1111/jvim.14892
Wielaender, Franziska, Sarviaho, R., James, F., Hytönen, M. K., Cortez, M. A., Kluger, G., … Lohi, H. (2017). Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1. Proceedings of the National Academy of Sciences, 114(10), 2669–2674. https://doi.org/10.1073/pnas.1614478114 |
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Grant Number: 01849 Research Program Area: Cardiology |
Filling the Gaps in the Canine Genome Li, Y., Xu, J., Xiong, H., Ma, Z., Wang, Z., Kipreos, E. T., … Zhao, S. (2014). Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis. Oncoscience, 1, 854. https://doi.org/10.18632/oncoscience.107
Liu, D., Xiong, H., Ellis, A. E., Northrup, N. C., Rodriguez, C. O., O’Regan, R. M., … Zhao, S. (2014). Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer. Cancer Research, 74(18), 5045–5056. https://doi.org/10.1158/0008-5472.CAN-14-0392
Liu, Deli, Xiong, H., Ellis, A. E., Northrup, N. C., Dobbin, K. K., Shin, D. M., & Zhao, S. (2015). Canine Spontaneous Head and Neck Squamous Cell Carcinomas Represent Their Human Counterparts at the Molecular Level. PLOS Genetics, 11(6), e1005277. https://doi.org/10.1371/journal.pgen.1005277
Wang, J., Wang, T., Bishop, M. A., Edwards, J. F., Yin, H., Dalton, S., … Zhao, S. (2018). Collaborating genomic, transcriptomic and microbiomic alterations lead to canine extreme intestinal polyposis. Oncotarget, 9(49). https://doi.org/10.18632/oncotarget.25646
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Grant Number: 01746-A Research Program Area: Dermatology and Allergic Disease |
Discovery of the Genetic Cause of Lethal Acrodermatitis Bauer, A., Jagannathan, V., Högler, S., Richter, B., McEwan, N. A., Thomas, A., … Leeb, T. (2018). MKLN1 splicing defect in dogs with lethal acrodermatitis. PLOS Genetics, 14(3), e1007264. https://doi.org/10.1371/journal.pgen.1007264 |
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Grant Number: 01584 Research Program Area: Musculoskeletal Conditions and Disease |
Creation of a Conformation Score to Evaluate Susceptibility to Cranial Cruciate Ligament Disease Cunningham, D. P., Mostafa, A. A., Gordan-Evans, W. J., Boudrieau, R. J., & Griffon, D. J. (2017). Factors contributing to the variability of a predictive score for cranial cruciate ligament deficiency in Labrador Retrievers. BMC Veterinary Research, 13(1). https://doi.org/10.1186/s12917-017-1154-9 Griffon, D. J., Cunningham, D., Gordon-Evans, W. J., Tanaka, R., Bruecker, K. A., & Boudrieau, R. J. (2017). Evaluation of a scoring system based on conformation factors to predict cranial cruciate ligament disease in Labrador Retrievers. Veterinary Surgery, 46(2), 206–212. https://doi.org/10.1111/vsu.12593 Keebaugh, A. E., Redman-Bentley, D., & Griffon, D. J. (2015). Influence of leash side and handlers on pressure mat analysis of gait characteristics in small-breed dogs. Journal of the American Veterinary Medical Association, 246(11), 1215–1221. https://doi.org/10.2460/javma.246.11.1215 Mostafa, A. A., Cunningham, D. P., Boudrieau, R. J., Kowaleski, M. P., & Griffon, D. J. (2018). Influence of radiographic techniques on the measurement of femoral anteversion angles and a conformation score of pelvic limbs in Labrador Retrievers. Veterinary Surgery, 47(3), 421–430. https://doi.org/10.1111/vsu.12782 Ragetly, C. A., Griffon, D. J., Hsu, M. K. I., Klump, L. M., & Hsiao-Wecksler, E. T. (2012). Kinetic and kinematic analysis of the right hind limb during trotting on a treadmill in Labrador Retrievers presumed predisposed or not predisposed to cranial cruciate ligament disease. American Journal of Veterinary Research, 73(8), 1171–1177. https://doi.org/10.2460/ajvr.73.8.1171 Ragetly, C. A., Griffon, D. J., Klump, L. M., & Hsiao-Wecksler, E. T. (2012). Pelvic Limb Kinetic and Kinematic Analysis in Labrador Retrievers Predisposed or at a Low Risk for Cranial Cruciate Ligament Disease: Pelvic Limbs Kinetic and Kinematic Analysis in Labrador Retrievers. Veterinary Surgery, 41(8), 973–982. https://doi.org/10.1111/j.1532-950X.2012.01042.x |
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Grant Number: 822 Research Program Area: Oncology |
Canine Comparative Oncology and Genomics Consortium (CCOGC) Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Lindblad-Toh, K. (2018). SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma. Cancer Research, canres.3558.2017. https://doi.org/10.1158/0008-5472.CAN-17-3558
Webster, J. D., Simpson, E. R., Michalowski, A. M., Hoover, S. B., & Simpson, R. M. (2011). Quantifying Histological Features of Cancer Biospecimens for Biobanking Quality Assurance Using Automated Morphometric Pattern Recognition Image Analysis Algorithms. Journal of Biomolecular Techniques, 22(3), 11. |
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Grant Number: 01708-A Research Program Area: Oncology |
Validation of a general method for enrichment of canine cancer stem cells Frantz, A. M. (2013). Comparative and molecular approaches to improve identification, classification, and therapeutic approaches to cancer. Retrieved from http://conservancy.umn.edu/handle/11299/144793 Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368 Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020 |
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Grant Number: 02138 Research Program Area: Endocrinology |
Development of Accurate Diagnostic Tests for Canine Hypothyroidism Pijnacker, T., Kooistra, H. S., Vermeulen, C. F., van der Vinne, M., Prins, M., Galac, S., & Mol, J. A. (2018). Use of basal and TRH-stimulated plasma growth hormone concentrations to differentiate between primary hypothyroidism and nonthyroidal illness in dogs. Journal of Veterinary Internal Medicine, 32(4), 1319–1324. https://doi.org/10.1111/jvim.15139 |
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Grant Number: 02243-A Research Program Area: Ophthalmology |
Genomic Profiling of Canine Corneal Endothelial Dystrophy Shull, O. R., Reilly, C. M., Davis, L. B., Murphy, C. J., & Thomasy, S. M. (2018). Phenotypic Characterization of Corneal Endothelial Dystrophy in German Shorthaired and Wirehaired Pointers Using In Vivo Advanced Corneal Imaging and Histopathology: Cornea, 37(1), 88–94. https://doi.org/10.1097/ICO.0000000000001431
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Grant Number: 02078 Research Program Area: Musculoskeletal Conditions and Disease |
Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs Bearden, R. N., Huggins, S. S., Cummings, K. J., Smith, R., Gregory, C. A., & Saunders, W. B. (2017). In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study. Stem Cell Research & Therapy, 8(1). https://doi.org/10.1186/s13287-017-0639-6 Diaz‐Rodriguez, P., Erndt‐Marino, J. D., Gharat, T., Pinto, D. J. M., Samavedi, S., Bearden, R., … Hahn, M. S. (2018). Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 1–11. https://doi.org/10.1002/jbm.b.34293 Gacasan, E. G., Sehnert, R. M., Ehrhardt, D. A., & Grunlan, M. A. (2017). Templated, Macroporous PEG-DA Hydrogels and Their Potential Utility as Tissue Engineering Scaffolds. Macromolecular Materials and Engineering, 302(5), 1600512. https://doi.org/10.1002/mame.201600512 Gharat, T. P., Diaz-Rodriguez, P., Erndt-Marino, J. D., Jimenez Vergara, A. C., Munoz Pinto, D. J., Bearden, R. N., … Hahn, M. S. (2018). A canine in vitro model for evaluation of marrow‐derived mesenchymal stromal cell‐based bone scaffolds. Journal of Biomedical Materials Research Part A, 106(9), 2382–2393. https://doi.org/10.1002/jbm.a.36430 |
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Grant Number: 01421 Research Program Area: Dermatology and Allergic Disease |
Genomic Resources for the Control of Canine Pyoderma Moodley, A., Riley, M. C., Kania, S. A., & Guardabassi, L. (2013). Genome Sequence of Staphylococcus pseudintermedius Strain E140, an ST71 European-Associated Methicillin-Resistant Isolate. Genome Announcements, 1(2). https://doi.org/10.1128/genomeA.00207-12 Riley, M. C., Perreten, V., Bemis, D. A., & Kania, S. A. (2016). Complete Genome Sequences of Three Important Methicillin-Resistant Clinical Isolates of Staphylococcus pseudintermedius. Genome Announcements, 4(5). https://doi.org/10.1128/genomeA.01194-16 Solyman, S. M., Black, C. C., Duim, B., Perreten, V., van Duijkeren, E., Wagenaar, J. A., … Kania, S. A. (2013). Multilocus Sequence Typing for Characterization of Staphylococcus pseudintermedius. Journal of Clinical Microbiology, 51(1), 306–310. https://doi.org/10.1128/JCM.02421-12 Videla, R., Solyman, S. M., Brahmbhatt, A., Sadeghi, L., Bemis, D. A., & Kania, S. A. (2018). Clonal Complexes and Antimicrobial Susceptibility Profiles of Staphylococcus pseudintermedius Isolates from Dogs in the United States. Microbial Drug Resistance, 24(1), 83–88. https://doi.org/10.1089/mdr.2016.0250 |
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Grant Number: 02315-A Research Program Area: Oncology - Lymphoma |
Discovering Peptide Targets for Development of Adoptive Cell Therapy for Peripheral T-Cell Lymphoma Nemec, P. S., Kapatos, A., Holmes, J. C., & Hess, P. R. (2018). The prevalent Boxer MHC class Ia allotype dog leukocyte antigen (DLA)-88*034:01 preferentially binds nonamer peptides with a defined motif. HLA, 92(6), 403–407. https://doi.org/10.1111/tan.13398
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Grant Number: 01826 Research Program Area: Oncology |
A Novel Treatment for Brain Tumors Using a One Medicine Approach Freeman, A. C., Platt, S. R., Holmes, S., Kent, M., Robinson, K., Howerth, E., … Hadjipanayis, C. G. (2018). Convection-enhanced delivery of cetuximab conjugated iron-oxide nanoparticles for treatment of spontaneous canine intracranial gliomas. Journal of Neuro-Oncology, 137(3), 653–663. https://doi.org/10.1007/s11060-018-2764-1 |
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Grant Number: 02353-A Research Program Area: General Canine Health |
Characterization of Naturally-Occurring Neuropathic Pain in Dogs Ruel, H. L., Watanabe, R., Evangelista, M. C., Beauchamp, G., & Steagall, P. V. (2018). Feasibility and reliability of electrical, mechanical and thermal nociceptive testing and assessment of diffuse noxious inhibitory control in dogs. Journal of Pain Research, 11, 2491–2496. https://doi.org/10.2147/JPR.S164483 |
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Grant Number: 1658 Research Program Area: Kidney & Urological Disease |
Early Detection of Chronic Kidney Disease to Prevent Kidney Damage Hokamp, J. A., Cianciolo, R. E., Boggess, M., Lees, G. E., Benali, S. L., Kovarsky, M., & Nabity, M. B. (2016). Correlation of Urine and Serum Biomarkers with Renal Damage and Survival in Dogs with Naturally Occurring Proteinuric Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 30(2), 591–601. https://doi.org/10.1111/jvim.13832 Hokamp, J. A., Leidy, S. A., Gaynanova, I., Cianciolo, R. E., & Nabity, M. B. (2018). Correlation of electrophoretic urine protein banding patterns with severity of renal damage in dogs with proteinuric chronic kidney disease. Veterinary Clinical Pathology, 47(3), 425–434. https://doi.org/10.1111/vcp.12648 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
