00294-A: Enhancement of Current Background Information and DNA Material Necessary for the Future Development of a Molecular Genetics Study in Collies and Shetland Sheepdogs with Dermatomyositis

Grant Status: Closed

Grant Amount: $6,993
Dr. Christine Rees, DVM, Texas A&M University
July 1, 2004 - June 30, 2005
Breed(s): Shetland Sheepdog, Collie
Research Program Area: Prevention

Abstract

Dermatomyostitis is a devastating disease of the skin and/or muscle in Collies and Shetland Sheepdogs. The genetics of this medical problem are not well characterized. The mode of inheritance is known in Collies with DM but not in Shetland Sheepdogs. Analyzing pedigrees of DM affected and DM non-affected dogs is necessary to try to determine the mode of inheritance in Shetland Sheepdogs. Sufficient numbers of pedigrees from DM affected and DM non-affected Shetland Sheepdogs need to be collected in order for us to be able to achieve this goal. In addition, the development of a blood test to determine whether a dog has DM or not would also be beneficial. In order to develop such a test, we need adequate amounts of extracted DNA from both DM affected and DM unaffected dogs. Only after an adequate sample size of DNA from these two groups of dogs is collected will we be able to move forward with our research to try to find the gene marker(s) that can be used to make a DM blood test.

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