2071: Development of a Therapeutic Brain Tumor Vaccine

Grant Status: Closed

Grant Amount: $130,572
Dr. Grace Elizabeth Pluhar, DVM, PhD, University of Minnesota
January 1, 2014 - December 31, 2015
Sponsor(s): Gordon Setter Club of America, Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Welsh Terrier Club of America, Inc.
Breed(s): -All Dogs
Research Program Area: Oncology

Abstract

Meningiomas are the most common primary brain tumor in dogs that affects more than 10,000 dogs in the U.S. annually. These tumors occur most frequently in older dogs and in certain breeds -- Golden Retrievers, Labrador Retrievers, Boxers, German Shepherd Dogs and Collies -- causing uncontrolled generalized grand mal seizures in most cases. Although the biological behavior of these tumors is generally considered benign, most meningiomas recur less than one year after either surgery or radiation therapy. Furthermore, radiation therapy is expensive, involves many, repeated episodes of general anesthesia, and cause severe adverse effects. Longer survival times can be achieved through special techniques, but most dogs treated undergo more standard surgical removal and/or radiation therapy. Clearly, there is an urgent need for novel therapies to prevent tumor recurrence and increase survival time after surgery. Dr. Pluhar has developed immunotherapy protocols for dogs with gliomas, and recently assessed this strategy in a pilot study treating meningiomas with tumor lysate vaccines. Her data for six dogs showed this approach was safe, feasible and effective. Dr. Pluhar now proposes a larger clinical trial treating 30 dogs with meningioma by surgery alone or surgery followed by vaccines. They expect to see a specific immune response to the vaccines that prevents tumor recurrence. The data from the proposed study will provide further proof of safety and efficacy of vaccine-based therapy to support: 1) more widespread use in dogs and 2) initiation of a Phase I trial for high grade and recurrent meningioma in humans.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software