02110-A: Investigating the Effects of an Infusion of Fenoldopam on Kidney Function to Improve Outcomes of Acute Kidney Injury Patients

Grant Status: Open

Grant Amount: $11,493.36
Dr. Jonathan D Foster, VMD, University of Pennsylvania
November 1, 2014 - October 31, 2015
Sponsor(s): Havanese Club of America, Hoffman Miniature Schnauzer Donor Advised Fund
Breed(s): -All Dogs
Research Program Area: Renal Disease

Abstract

Acute kidney injury (AKI) is a devastating disease in canine patients. AKI represents a spectrum of disease characterized by a rapid loss of kidney function, resulting in impaired kidney filtration of metabolic waste products. Regardless of the inciting injury, the resulting kidney dysfunction causes increased serum kidney values and often decreased urine production. The resulting retention of metabolic waste products causes the clinical illness of AKI. Decreased urine production (oliguria) or complete cessation of urine production (anuria) may indicate a more severe kidney injury and are associated with increased mortality. Patients with decreased urine production are more difficult to manage when hospitalized and have higher morbidity than patients with normal urine output. Therapeutic intervention with diuretics has historically been performed in an attempt to induce urine production and thus facilitate the filtration and excretion of metabolic wastes. Unfortunately these therapies are often ineffective and are not without risk of unwanted side effects. Fenoldopam (a selective dopamine DA-1 receptor agonist that induces renal vasodilation) has recently been shown to increase urine production in people with minimal side effects. Little is known regarding the effect of the drug on kidney filtration and whether there is potential for its use in dogs. The purpose of this study is to determine the effect of fenoldopam on kidney filtration by measuring glomerular filtration rate during fenoldopam administration. If fenoldopam increases filtration rate it may in turn facilitate removal of metabolic waste products, potentially leading to improved outcome in patients with AKI and decreased urine production.

Publication(s)

Kelly, K. L., Drobatz, K. J., & Foster, J. D. (2016). Effect of Fenoldopam Continuous Infusion on Glomerular Filtration Rate and Fractional Excretion of Sodium in Healthy Dogs. Journal of Veterinary Internal Medicine, 30(5), 1655–1660. http://doi.org/10.1111/jvim.14522

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