Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
|
Grant Number: 961 Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Hunt, M., Otto, C. M., Serpell, J. A., & Alvarez, J. (2012). Interactions between Handler Well-Being and Canine Health and Behavior in Search and Rescue Teams. Anthrozoös, 25(3), 323–335. https://doi.org/10.2752/175303712X13403555186253 Otto, C. M., Downend, A. B., Moore, G. E., Daggy, J. K., Ranivand, D. L., Reetz, J. A., & Fitzgerald, S. D. (2009). Medical surveillance of search dogs deployed to the World Trade Center and Pentagon: 2001-2006. Journal of Veterinary Behavior, 4(6), 241. https://doi.org/10.1016/j.jveb.2009.04.002 Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: Lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x New article: Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
|
Grant Number: 02245-MOU Research Program Area: Immunology and Infectious Disease |
Genetic Predisposition to Avian Tuberculosis in Miniature Schnauzers and Bassets Hounds Ghielmetti, G., & Giger, U. (2020). Mycobacterium avium: An Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies. Current Clinical Microbiology Reports, 7(3), 67–80. https://doi.org/10.1007/s40588-020-00145-5 |
|
Grant Number: 01488-A Research Program Area: Reproductive Conditions |
Health Implications of Spay and Neuter: Golden Retriever and Labrador Retriever Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2020). Assisting Decision-Making on Age of Neutering for 35 Breeds of Dogs: Associated Joint Disorders, Cancers, and Urinary Incontinence. Frontiers in Veterinary Science, 7. https://doi.org/10.3389/fvets.2020.00388 Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2014). Long-Term Health Effects of Neutering Dogs: Comparison of Labrador Retrievers with Golden Retrievers. PLoS ONE, 9(7), e102241. https://doi.org/10.1371/journal.pone.0102241 Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2016). Neutering of German Shepherd Dogs: associated joint disorders, cancers and urinary incontinence. Veterinary Medicine and Science, 2(3), 191–199. https://doi.org/10.1002/vms3.34 Torres de la Riva, G., Hart, B. L., Farver, T. B., Oberbauer, A. M., Messam, L. L. McV., Willits, N., & Hart, L. A. (2013). Neutering Dogs: Effects on Joint Disorders and Cancers in Golden Retrievers. PLoS ONE, 8(2), e55937. https://doi.org/10.1371/journal.pone.0055937 |
|
Grant Number: 01982 Research Program Area: Cardiology |
Personalized Medicine: The Intersection of Genotype and Drug Responsiveness in the Treatment of Canine Pulmonary Hypertension Visser, L. C., Wood, J. E., & Johnson, L. R. (2020). Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15826
Visser, L. C., Im, M. K., Johnson, L. R., & Stern, J. A. (2016). Diagnostic Value of Right Pulmonary Artery Distensibility Index in Dogs with Pulmonary Hypertension: Comparison with Doppler Echocardiographic Estimates of Pulmonary Arterial Pressure. Journal of Veterinary Internal Medicine, 30(2), 543–552. https://doi.org/10.1111/jvim.13911
Ueda, Y., Johnson, L. R., Ontiveros, E. S., Visser, L. C., Gunther-Harrington, C. T., & Stern, J. A. (2019). Effect of a phosphodiesterase-5A ( PDE5A ) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension. Scientific Reports, 9(1), 6899. https://doi.org/10.1038/s41598-019-43318-z
Johnson, L. R., & Stern, J. A. (2019). Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15679
|
|
Grant Number: 02322 Research Program Area: General Canine Health |
Analysis of the Health, Behavioral, and Longevity Data Collected in the 9/11 Medical Surveillance Longitudinal Study Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Hare, E., Kelsey, K. M., Serpell, J. A., & Otto, C. M. (2018). Behavior Differences Between Search-and-Rescue and Pet Dogs. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00118 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Article: Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
|
Grant Number: 610 Research Program Area: Endocrinology |
Evaluation of Genetic Markers for Diabetes Mellitus in Samoyed and Australian Terrier Dogs Mui, M. L., Famula, T. R., Henthorn, P. S., & Hess, R. S. (2020). Heritability and complex segregation analysis of naturally-occurring diabetes in Australian Terrier Dogs. PLOS ONE, 15(9), e0239542. https://doi.org/10.1371/journal.pone.0239542 Hess, R., Henthorn, P., Devoto, M., Wang, F., & Feng, R. (2019). An exploratory association analysis of the insulin gene region with diabetes mellitus in two dog breeds. The Journal of Heredity. https://doi.org/10.1093/jhered/esz059 |
|
Grant Number: 02522-A Research Program Area: Oncology |
The Investigation of Lypoxigenase-5 Expression in Canine Normal, Hyperplastic and Neoplastic Urinary Bladder Epithelium Finotello, R., Schiavo, L., Ressel, L., Frohmader, A., Silvestrini, P., & Verin, R. (2019). Lipoxygenase-5 Expression in Canine Urinary Bladder: Normal Urothelium, Cystitis and Transitional Cell Carcinoma. Journal of Comparative Pathology, 170, 1–9. https://doi.org/10.1016/j.jcpa.2019.05.001
|
|
Grant Number: 01075-A Research Program Area: Dermatology and Allergic Disease |
Description and Characterization of a Hair Coat Disorder in Schipperkes May, E. R., Frank, L. A., & Sula, M.-J. M. (2019). Description and characterization of a hair coat disorder in schipperkes. Veterinary Dermatology, 30(1), 36-e10. https://doi.org/10.1111/vde.12711 |
|
Grant Number: 01896-A Research Program Area: Epilepsy Initiative |
A Pilot Study: Establishing the Role of Melatonin in the Occurrence of Seizures in Dogs Thomovsky, S. A., Chen, A. V., Deavila, D. M., & Kiszonas, A. M. (2019). Serum Melatonin Values in Normal Dogs and Dogs with Seizures. Journal of the American Animal Hospital Association. https://doi.org/10.5326/JAAHA-MS-6669 |
|
Grant Number: 01131 Research Program Area: Oncology - Hemangiosarcoma |
Genetic Background and the Angiogenic Phenotype in Cancer Borgatti, A. (2014). Binding of VEGF-A to canine cancer cells with preferential expression of VEGFR1. Veterinary World, 7(1), 1–6. https://doi.org/10.14202/vetworld.2014.1-6 Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025 Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368 Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020 Koopmeiners, J. S., & Modiano, J. (2014). A Bayesian adaptive Phase I-II clinical trial for evaluating efficacy and toxicity with delayed outcomes. Clinical Trials (London, England), 11(1), 38–48. https://doi.org/10.1177/1740774513500589 Rinz, C. J., Levine, J., Minor, K. M., Humphries, H. D., Lara, R., Starr-Moss, A. N., … Clark, L. A. (2014). A COLQ Missense Mutation in Labrador Retrievers Having Congenital Myasthenic Syndrome. PLoS ONE, 9(8), e106425. https://doi.org/10.1371/journal.pone.0106425 Schappa, J. T., Frantz, A. M., Gorden, B. H., Dickerson, E. B., Vallera, D. A., & Modiano, J. F. (2013). Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors: Bispecific ligand-targeted toxins. International Journal of Cancer, 133(8), 1936–1944. https://doi.org/10.1002/ijc.28187 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
|
Grant Number: 02152 Research Program Area: Kidney & Urological Disease |
Translation of MicroRNA into an Early Diagnostic Test for Chronic Kidney Disease Chu, C. P., & Nabity, M. B. (2019). Comparison of RNA isolation and library preparation methods for small RNA sequencing of canine biofluids. Veterinary Clinical Pathology, 0(0). https://doi.org/10.1111/vcp.12743 |
|
Grant Number: 01828 Research Program Area: Musculoskeletal Conditions and Disease |
Mapping of Genetic Risk Factors for Canine Hip Dysplasia Mikkola, L., Kyöstilä, K., Donner, J., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2021). An across-breed validation study of 46 genetic markers in canine hip dysplasia. BMC Genomics, 22(1), 68. https://doi.org/10.1186/s12864-021-07375-x Mikkola, L. I., Holopainen, S., Lappalainen, A. K., Pessa-Morikawa, T., Augustine, T. J. P., Arumilli, M., & Hyt, M. K. (2019). Novel protective and risk loci in hip dysplasia in German Shepherds. PLoS Genetics, 15(7), e1008197. https://doi.org/10.1371/journal.pgen.1008197 Mikkola, L., Holopainen, S., Pessa-Morikawa, T., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2019). Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci BMC Genomics, 20(1027), 1–13. doi.org/10.1186/s12864-019-6422-6 |
|
Grant Number: 02241 Research Program Area: Dermatology and Allergic Disease |
The City Dog Study: Dermatologic and Respiratory Disease among Inner-City Dogs Living in the Homes of Children with Asthma Exum NG, Olórtegui MP, Yori PP, et al. (2016). Floors and Toilets: Association of Floors and Sanitation Practices with Fecal Contamination in Peruvian Amazon Peri-Urban Households. Environ Sci Technol. 50 (14):7373-7381. doi:10.1021/acs.est.6b01283. Tsou, P.-Y., McCormack, M. C., Matsui, E. C., Peng, R. D., Diette, G. B., Hansel, N. N., & Davis, M. F. (2019). The Effect of Dog Allergen Exposure on Asthma Morbidity among Inner-city Children with Asthma. Pediatric Allergy and Immunology, 0(ja). https://doi.org/10.1111/pai.13144
|
|
Grant Number: 00572-A Research Program Area: Dermatology and Allergic Disease |
Heritability of Atopic Dermatitis in West Highland White Terriers Agler, C. S., Friedenberg, S., Olivry, T., Meurs, K. M., & Olby, N. J. (2019). Genome-wide association analysis in West Highland White Terriers with atopic dermatitis. Veterinary Immunology and Immunopathology, 209, 1–6. https://doi.org/10.1016/j.vetimm.2019.01.004
Wong, A. K., Ruhe, A. L., Dumont, B. L., Robertson, K. R., Guerrero, G., Shull, S. M., … Neff, M. W. (2010). A Comprehensive Linkage Map of the Dog Genome. Genetics, 184(2), 595–605. https://doi.org/10.1534/genetics.109.106831 |
|
Grant Number: 01426 Research Program Area: Oncology |
Personalized Medicine for the Treatment of Canine Mast Cell Tumors Halsey, C. H. C., Thamm, D. H., Weishaar, K. M., Burton, J. H., Charles, J. B., Gustafson, D. L., … Ehrhart, E. J. (2017). Expression of Phosphorylated KIT in Canine Mast Cell Tumor. Veterinary Pathology, 54(3), 387–394. https://doi.org/10.1177/0300985816688943
Thamm, D. H., Weishaar, K. M., Charles, J. B., & Ehrhart, E. J. (2019, July 31). Phosphorylated KIT as a Predictor of Outcome in Canine Mast Cell Tumours Treated with Toceranib Phosphate or Vinblastine. https://doi.org/10.1111/vco.12525
Weishaar, K. M., Ehrhart, E. J., Avery, A. C., Charles, J. B., Elmslie, R. E., Vail, D. M., … Thamm, D. H. (2018). c-Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated with Prednisone and Toceranib or Vinblastine. Journal of Veterinary Internal Medicine, 32(1), 394–405. https://doi.org/10.1111/jvim.14889
|
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
