Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02152 Research Program Area: Kidney & Urological Disease |
Translation of MicroRNA into an Early Diagnostic Test for Chronic Kidney Disease Chu, C. P., & Nabity, M. B. (2019). Comparison of RNA isolation and library preparation methods for small RNA sequencing of canine biofluids. Veterinary Clinical Pathology, 0(0). https://doi.org/10.1111/vcp.12743 |
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Grant Number: 422 Research Program Area: Oncology - Hemangiosarcoma |
Tailored Antitumor Vaccines for Canine Hemangiosarcoma Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368
Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020
Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., … Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619
Tamburini, B. A., Trapp, S., Phang, T. L., Schappa, J. T., Hunter, L. E., & Modiano, J. F. (2009). Gene Expression Profiles of Sporadic Canine Hemangiosarcoma Are Uniquely Associated with Breed. PLoS ONE, 4(5), e5549. https://doi.org/10.1371/journal.pone.0005549
Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922
Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
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Grant Number: 02161-A Research Program Area: General Canine Health |
Supporting the Evidence-Based Use of Antibiotic Gels after Extensive Dental Plaque Removal in Dogs Martel, D. P., Fox, P. R., Lamb, K. E., & Carmichael, D. T. (2019). Comparison of closed root planing with versus without concurrent doxycycline hyclate or clindamycin hydrochloride gel application for the treatment of periodontal disease in dogs. Journal of the American Veterinary Medical Association, 254(3), 373–379. https://doi.org/10.2460/javma.254.3.373 |
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Grant Number: 02522-A Research Program Area: Oncology |
The Investigation of Lypoxigenase-5 Expression in Canine Normal, Hyperplastic and Neoplastic Urinary Bladder Epithelium Finotello, R., Schiavo, L., Ressel, L., Frohmader, A., Silvestrini, P., & Verin, R. (2019). Lipoxygenase-5 Expression in Canine Urinary Bladder: Normal Urothelium, Cystitis and Transitional Cell Carcinoma. Journal of Comparative Pathology, 170, 1–9. https://doi.org/10.1016/j.jcpa.2019.05.001
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Grant Number: 02192-A Research Program Area: Reproductive Conditions |
Advanced Semen Analysis in Labrador Retrievers Fuente-Lara, A. de la, Hesser, A., Christensen, B., Gonzales, K., & Meyers, S. (2019). Effects from aging on semen quality of fresh and cryopreserved semen in Labrador Retrievers. Theriogenology. https://doi.org/10.1016/j.theriogenology.2019.04.013 Hesser, A., Darr, C., Gonzales, K., Power, H., Scanlan, T., Thompson, J., … Meyers, S. (2017). Semen evaluation and fertility assessment in a purebred dog breeding facility. Theriogenology, 87, 115–123. https://doi.org/10.1016/j.theriogenology.2016.08.012
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Grant Number: 01131 Research Program Area: Oncology - Hemangiosarcoma |
Genetic Background and the Angiogenic Phenotype in Cancer Borgatti, A. (2014). Binding of VEGF-A to canine cancer cells with preferential expression of VEGFR1. Veterinary World, 7(1), 1–6. https://doi.org/10.14202/vetworld.2014.1-6 Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025 Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368 Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020 Koopmeiners, J. S., & Modiano, J. (2014). A Bayesian adaptive Phase I-II clinical trial for evaluating efficacy and toxicity with delayed outcomes. Clinical Trials (London, England), 11(1), 38–48. https://doi.org/10.1177/1740774513500589 Rinz, C. J., Levine, J., Minor, K. M., Humphries, H. D., Lara, R., Starr-Moss, A. N., … Clark, L. A. (2014). A COLQ Missense Mutation in Labrador Retrievers Having Congenital Myasthenic Syndrome. PLoS ONE, 9(8), e106425. https://doi.org/10.1371/journal.pone.0106425 Schappa, J. T., Frantz, A. M., Gorden, B. H., Dickerson, E. B., Vallera, D. A., & Modiano, J. F. (2013). Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors: Bispecific ligand-targeted toxins. International Journal of Cancer, 133(8), 1936–1944. https://doi.org/10.1002/ijc.28187 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922 Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
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Grant Number: 01896-A Research Program Area: Epilepsy Initiative |
A Pilot Study: Establishing the Role of Melatonin in the Occurrence of Seizures in Dogs Thomovsky, S. A., Chen, A. V., Deavila, D. M., & Kiszonas, A. M. (2019). Serum Melatonin Values in Normal Dogs and Dogs with Seizures. Journal of the American Animal Hospital Association. https://doi.org/10.5326/JAAHA-MS-6669 |
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Grant Number: 02171-MOU Research Program Area: Oncology |
Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment Ontiveros, E. S., Hughes, S., Penedo, M. C. T., Grahn, R. A., & Stern, J. A. (2019). Genetic heterogeneity and diversity of North American Golden Retrievers using a low density STR marker panel. PLOS ONE, 14(2), e0212171. https://doi.org/10.1371/journal.pone.0212171 |
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Grant Number: 01426 Research Program Area: Oncology |
Personalized Medicine for the Treatment of Canine Mast Cell Tumors Halsey, C. H. C., Thamm, D. H., Weishaar, K. M., Burton, J. H., Charles, J. B., Gustafson, D. L., … Ehrhart, E. J. (2017). Expression of Phosphorylated KIT in Canine Mast Cell Tumor. Veterinary Pathology, 54(3), 387–394. https://doi.org/10.1177/0300985816688943
Thamm, D. H., Weishaar, K. M., Charles, J. B., & Ehrhart, E. J. (2019, July 31). Phosphorylated KIT as a Predictor of Outcome in Canine Mast Cell Tumours Treated with Toceranib Phosphate or Vinblastine. https://doi.org/10.1111/vco.12525
Weishaar, K. M., Ehrhart, E. J., Avery, A. C., Charles, J. B., Elmslie, R. E., Vail, D. M., … Thamm, D. H. (2018). c-Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated with Prednisone and Toceranib or Vinblastine. Journal of Veterinary Internal Medicine, 32(1), 394–405. https://doi.org/10.1111/jvim.14889
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Grant Number: 00572-A Research Program Area: Dermatology and Allergic Disease |
Heritability of Atopic Dermatitis in West Highland White Terriers Agler, C. S., Friedenberg, S., Olivry, T., Meurs, K. M., & Olby, N. J. (2019). Genome-wide association analysis in West Highland White Terriers with atopic dermatitis. Veterinary Immunology and Immunopathology, 209, 1–6. https://doi.org/10.1016/j.vetimm.2019.01.004
Wong, A. K., Ruhe, A. L., Dumont, B. L., Robertson, K. R., Guerrero, G., Shull, S. M., … Neff, M. W. (2010). A Comprehensive Linkage Map of the Dog Genome. Genetics, 184(2), 595–605. https://doi.org/10.1534/genetics.109.106831 |
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Grant Number: 02241 Research Program Area: Dermatology and Allergic Disease |
The City Dog Study: Dermatologic and Respiratory Disease among Inner-City Dogs Living in the Homes of Children with Asthma Exum NG, Olórtegui MP, Yori PP, et al. (2016). Floors and Toilets: Association of Floors and Sanitation Practices with Fecal Contamination in Peruvian Amazon Peri-Urban Households. Environ Sci Technol. 50 (14):7373-7381. doi:10.1021/acs.est.6b01283. Tsou, P.-Y., McCormack, M. C., Matsui, E. C., Peng, R. D., Diette, G. B., Hansel, N. N., & Davis, M. F. (2019). The Effect of Dog Allergen Exposure on Asthma Morbidity among Inner-city Children with Asthma. Pediatric Allergy and Immunology, 0(ja). https://doi.org/10.1111/pai.13144
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Grant Number: 01746-A Research Program Area: Dermatology and Allergic Disease |
Discovery of the Genetic Cause of Lethal Acrodermatitis Bauer, A., Jagannathan, V., Högler, S., Richter, B., McEwan, N. A., Thomas, A., … Leeb, T. (2018). MKLN1 splicing defect in dogs with lethal acrodermatitis. PLOS Genetics, 14(3), e1007264. https://doi.org/10.1371/journal.pgen.1007264 |
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Grant Number: 02455-A Research Program Area: Oncology |
Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels
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Grant Number: 02078 Research Program Area: Musculoskeletal Conditions and Disease |
Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs Bearden, R. N., Huggins, S. S., Cummings, K. J., Smith, R., Gregory, C. A., & Saunders, W. B. (2017). In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study. Stem Cell Research & Therapy, 8(1). https://doi.org/10.1186/s13287-017-0639-6 Diaz‐Rodriguez, P., Erndt‐Marino, J. D., Gharat, T., Pinto, D. J. M., Samavedi, S., Bearden, R., … Hahn, M. S. (2018). Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 1–11. https://doi.org/10.1002/jbm.b.34293 Gacasan, E. G., Sehnert, R. M., Ehrhardt, D. A., & Grunlan, M. A. (2017). Templated, Macroporous PEG-DA Hydrogels and Their Potential Utility as Tissue Engineering Scaffolds. Macromolecular Materials and Engineering, 302(5), 1600512. https://doi.org/10.1002/mame.201600512 Gharat, T. P., Diaz-Rodriguez, P., Erndt-Marino, J. D., Jimenez Vergara, A. C., Munoz Pinto, D. J., Bearden, R. N., … Hahn, M. S. (2018). A canine in vitro model for evaluation of marrow‐derived mesenchymal stromal cell‐based bone scaffolds. Journal of Biomedical Materials Research Part A, 106(9), 2382–2393. https://doi.org/10.1002/jbm.a.36430 |
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Grant Number: 02231-A Research Program Area: General Canine Health |
Bioavailability of Suppository Acetaminophen for Treatment of Pain in Healthy and Critically Ill Dogs Sikina, E. R., Bach, J. F., Lin, Z., Gehring, R., & KuKanich, B. (2018). Bioavailability of suppository acetaminophen in healthy and hospitalized ill dogs. Journal of Veterinary Pharmacology and Therapeutics, 41(5), 652–658. https://doi.org/10.1111/jvp.12664 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
