Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01265 Research Program Area: Immunology and Infectious Disease |
Understanding Mechanisms Involved in Canine Autoimmune and Inflammatory Disorders Jalilian I. (2011).The canine P2X7 receptor. http://ro.uow.edu.au/theses/3458/. - Peranec M. The P2X7 receptor in canine monocytes. BSc (Hons) Thesis, University of Wollongong, 2011. Bartlett, R., Stokes, L., & Sluyter, R. (2014). The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease. Pharmacological Reviews, 66(3), 638–675. https://doi.org/10.1124/pr.113.008003 Jalilian, I., Peranec, M., Curtis, B. L., Seavers, A., Spildrejorde, M., Sluyter, V., & Sluyter, R. (2012). Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes. Veterinary Immunology and Immunopathology, 149(1–2), 86–91. https://doi.org/10.1016/j.vetimm.2012.05.004 Jalilian, I., Spildrejorde, M., Seavers, A., Curtis, B. L., McArthur, J. D., & Sluyter, R. (2012). Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells. Veterinary Immunology and Immunopathology, 150(3–4), 228–233. https://doi.org/10.1016/j.vetimm.2012.09.040 Spildrejorde, M., Bartlett, R., Stokes, L., Jalilian, I., Peranec, M., Sluyter, V., … Sluyter, R. (2014). R270C polymorphism leads to loss of function of the canine P2X7 receptor. Physiological Genomics, 46(14), 512–522. https://doi.org/10.1152/physiolgenomics.00195.2013 Wiley, J. S., Sluyter, R., Gu, B. J., Stokes, L., & Fuller, S. J. (2011). The human P2X7 receptor and its role in innate immunity. Tissue Antigens, 78(5), 321–332. https://doi.org/10.1111/j.1399-0039.2011.01780.x Sophocleous, R. A., Sluyter, V., Curtis, B. L., Curtis, S. J., Jurak, L. M., Faulks, M., … Sluyter, R. (2019). Association of a P2RX7 gene missense variant with brachycephalic dog breeds. Animal Genetics. https://doi.org/10.1111/age.12884 |
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Grant Number: 02267-A Research Program Area: Reproductive Conditions |
An Epidemiological Study of Brucella canis
Whitten, T. V., Brayshaw, G., Patnayak, D., Alvarez, J., Larson, C. M., Root Kustritz, M., … Scheftel, J. M. (2019). Seroprevalence of Brucella canis Antibodies in Dogs Entering a Minnesota Humane Society, Minnesota, 2016–2017. Preventive Veterinary Medicine. https://doi.org/10.1016/j.prevetmed.2019.04.015 |
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Grant Number: 02192-A Research Program Area: Reproductive Conditions |
Advanced Semen Analysis in Labrador Retrievers Fuente-Lara, A. de la, Hesser, A., Christensen, B., Gonzales, K., & Meyers, S. (2019). Effects from aging on semen quality of fresh and cryopreserved semen in Labrador Retrievers. Theriogenology. https://doi.org/10.1016/j.theriogenology.2019.04.013 Hesser, A., Darr, C., Gonzales, K., Power, H., Scanlan, T., Thompson, J., … Meyers, S. (2017). Semen evaluation and fertility assessment in a purebred dog breeding facility. Theriogenology, 87, 115–123. https://doi.org/10.1016/j.theriogenology.2016.08.012
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Grant Number: 02343-A Research Program Area: Blood Disorders |
Recognizing and Removing Lipemic Interferences for Accurate Laboratory Testing Azevedo, C. N., Lidbury, J. A., & Jeffery, U. (2019). Effects of marked hypertriglyceridemia and lipid clearance techniques on canine biochemistry testing. Journal of Veterinary Diagnostic Investigation, 1040638719858690. https://doi.org/10.1177/1040638719858690 |
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Grant Number: 02233-A Research Program Area: Gastrointestinal Disease |
Evaluation of a Novel Technique for Gastric Decompression in Dogs with Gastric Dilatation and Volvulus Fox-Alvarez, W. A., Case, J. B., Lewis, D. D., Joyce, A. C., Cooke, K. L., & Toskich, B. (2019). Evaluation of a novel technique involving ultrasound-guided, temporary, percutaneous gastropexy and gastrostomy catheter placement for providing sustained gastric decompression in dogs with gastric dilatation-volvulus. Journal of the American Veterinary Medical Association, 255(9), 1027–1034. https://doi.org/10.2460/javma.255.9.1027
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Grant Number: 02424 Research Program Area: Cardiology |
Identification of Genetic Variants Associated with Pulmonary Valve Stenosis in Bulldogs through Whole-Genome Sequencing Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052 |
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Grant Number: 02228-MOU Research Program Area: General Canine Health |
Assessing the Genetic Diversity of North American Golden Retrievers Ontiveros, E. S., Hughes, S., Penedo, M. C. T., Grahn, R. A., & Stern, J. A. (2019). Genetic heterogeneity and diversity of North American golden retrievers using a low density STR marker panel. PLOS ONE, 14(2), e0212171. https://doi.org/10.1371/journal.pone.0212171 |
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Grant Number: 02161-A Research Program Area: General Canine Health |
Supporting the Evidence-Based Use of Antibiotic Gels after Extensive Dental Plaque Removal in Dogs Martel, D. P., Fox, P. R., Lamb, K. E., & Carmichael, D. T. (2019). Comparison of closed root planing with versus without concurrent doxycycline hyclate or clindamycin hydrochloride gel application for the treatment of periodontal disease in dogs. Journal of the American Veterinary Medical Association, 254(3), 373–379. https://doi.org/10.2460/javma.254.3.373 |
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Grant Number: 422 Research Program Area: Oncology - Hemangiosarcoma |
Tailored Antitumor Vaccines for Canine Hemangiosarcoma Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368
Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020
Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., … Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619
Tamburini, B. A., Trapp, S., Phang, T. L., Schappa, J. T., Hunter, L. E., & Modiano, J. F. (2009). Gene Expression Profiles of Sporadic Canine Hemangiosarcoma Are Uniquely Associated with Breed. PLoS ONE, 4(5), e5549. https://doi.org/10.1371/journal.pone.0005549
Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922
Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
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Grant Number: 01591 Research Program Area: Dermatology and Allergic Disease |
Identification of the Genes That Confer Risk for Atopic Dermatitis Tengvall, K., Sundström, E., Wang, C. et al. Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis. Commun Biol 5, 1348 (2022). https://doi.org/10.1038/s42003-022-04279-8
Agler, C. S., Friedenberg, S., Olivry, T., Meurs, K. M., & Olby, N. J. (2019). Genome-wide association analysis in West Highland White Terriers with atopic dermatitis. Veterinary Immunology and Immunopathology, 209, 1–6. https://doi.org/10.1016/j.vetimm.2019.01.004
Salzmann, C. A., Olivry, T. J., Nielsen, D. M., Paps, J. S., Harris, T. L., & Olby, N. J. (2011). Genome-wide linkage study of atopic dermatitis in West Highland White Terriers. BMC Genetics, 12(1), 37. https://doi.org/10.1186/1471-2156-12-37
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Grant Number: 02188-A Research Program Area: Reproductive Conditions |
Combined Anti-Mullerian Hormone and Progesterone Testing for the Diagnosis of Canine Ovarian Remnant Syndrome Place, N. J., Cheraskin, J.-L., & Hansen, B. S. (2019). Evaluation of combined assessments of serum anti-Müllerian hormone and progesterone concentrations for the diagnosis of ovarian remnant syndrome in dogs. Journal of the American Veterinary Medical Association, 254(9), 1067–1072. https://doi.org/10.2460/javma.254.9.1067 |
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Grant Number: 02182-A Research Program Area: Dermatology and Allergic Disease |
Is Defective Secretion of Antimicrobial Peptides Associated with Reduced Microbicidal Effects in Atopic Keratinocytes? Santoro, D., Archer, L., & Kelley, K. (2019). A defective release of host defense peptides is present in canine atopic skin - ScienceDirect. Comparative Immunology, Microbiology and Infectious Diseases. https://doi.org/Comparative Immunology, Microbiology and Infectious Diseases |
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Grant Number: 02171-MOU Research Program Area: Oncology |
Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment Ontiveros, E. S., Hughes, S., Penedo, M. C. T., Grahn, R. A., & Stern, J. A. (2019). Genetic heterogeneity and diversity of North American Golden Retrievers using a low density STR marker panel. PLOS ONE, 14(2), e0212171. https://doi.org/10.1371/journal.pone.0212171 |
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Grant Number: 2011 Research Program Area: Endocrinology |
Identification of Novel Drugs to Halt the Metastasis of Tumors That Cause Cushing's Syndrome Galac, S., Kool, M. M. J., van den Berg, M. F., Mol, J. A., & Kooistra, H. S. (2014). Expression of steroidogenic factor 1 in canine cortisol-secreting adrenocortical tumors and normal adrenals. Domestic Animal Endocrinology, 49, 1–5. https://doi.org/10.1016/j.domaniend.2014.04.002
Galac, Sara. (2016). Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine. Molecular and Cellular Endocrinology, 421, 34–39. https://doi.org/10.1016/j.mce.2015.06.026
Galac, Sara, & Wilson, D. B. (2015). Animal Models of Adrenocortical Tumorigenesis. Endocrinology and Metabolism Clinics of North America, 44(2), 297–310. https://doi.org/10.1016/j.ecl.2015.02.003
Sanders, K., Mol, J. A., Kooistra, H. S., Slob, A., & Galac, S. (2016). New Insights in the Functional Zonation of the Canine Adrenal Cortex. Journal of Veterinary Internal Medicine, 30(3), 741–750. https://doi.org/10.1111/jvim.13946
Sanders, K., Mol, J. A., Slob, A., Kooistra, H. S., & Galac, S. (2018a). Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: In vitro study. Domestic Animal Endocrinology, 63, 23–30. https://doi.org/10.1016/j.domaniend.2017.11.001
Sanders, K., Mol, J. A., Slob, A., Kooistra, H. S., & Galac, S. (2018b). Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: In vitro study. Domestic Animal Endocrinology, 63, 23–30. https://doi.org/10.1016/j.domaniend.2017.11.001
Sanders, R. A., Kurosawa, T. A., & Sist, M. D. (2018). Ambulatory electrocardiographic evaluation of the occurrence of arrhythmias in healthy Salukis. Journal of the American Veterinary Medical Association, 252(8), 966–969. https://doi.org/10.2460/javma.252.8.966 |
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Grant Number: 01869-A Research Program Area: Musculoskeletal Conditions and Disease |
Addendum to 1584: Creation of a Conformation Score To Evaluate Susceptibility to Cranial Cruciate Ligament Disease Cunningham, D. P., Mostafa, A. A., Gordan-Evans, W. J., Boudrieau, R. J., & Griffon, D. J. (2017). Factors contributing to the variability of a predictive score for cranial cruciate ligament deficiency in Labrador Retrievers. BMC Veterinary Research, 13(1). https://doi.org/10.1186/s12917-017-1154-9
Griffon, D. J., Cunningham, D., Gordon-Evans, W. J., Tanaka, R., Bruecker, K. A., & Boudrieau, R. J. (2017). Evaluation of a scoring system based on conformation factors to predict cranial cruciate ligament disease in Labrador Retrievers. Veterinary Surgery, 46(2), 206–212. https://doi.org/10.1111/vsu.12593
Mostafa, A. A., Cunningham, D. P., Boudrieau, R. J., Kowaleski, M. P., & Griffon, D. J. (2018). Influence of radiographic techniques on the measurement of femoral anteversion angles and a conformation score of pelvic limbs in Labrador Retrievers. Veterinary Surgery, 47(3), 421–430. https://doi.org/10.1111/vsu.12782 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
