01746-A: Discovery of the Genetic Cause of Lethal Acrodermatitis
Grant Status: Closed
AbstractLethal acrodermatitis (LAD) is a rare but significant disease of bull terrier dogs in the United States, Canada, and Europe. Affected dogs present with a highly arched palate and inflamed footpads that cause constant pain and predispose dogs to secondary illness. Earlier studies suggested that this disease is caused by a defect in zinc transport/metabolism but subsequent studies failed to replicate those results. Dr. Casal's laboratory, in collaboration with Dr. Catherine Andr�'s laboratory, have sequenced almost all of the genes currently known to participate in zinc metabolism but have not yet found a mutation. Drs. Casal and Andr� will conduct a genome wide association study to identify the gene(s) involved with this disease. Their goal is to develop a DNA test to assist breeders in identifying carriers of LAD to plan future breeding and also allow identification of a novel gene for a rare form of human acrodermatitis.
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