Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
Grant Number: 02232-MOU Research Program Area: Lung and Respiratory Disease |
Characterization of Upper Airway Syndrome in Norwich Terriers Johnson, L. R., Mayhew, P. D., Culp, W. T. N., & Stanley, B. J. (2021). Results of owner questionnaires describing long-term outcome in Norwich terriers with upper airway syndrome: 2011-2018. Journal of Veterinary Internal Medicine, (1-7). https://doi.org/10.1111/jvim.16180 |
Grant Number: 01986 Research Program Area: Hepatic Disease |
Profiling the Metabolic and Lipid Imbalances that are Causative of Gallbladder Disease in Dogs Lindaberry, C., Vaden, S., Aicher, K. M., Seiler, G., Robertson, J., Cianciolo, R., Yang, C., & Gookin, J. L. (2021). Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16051 Aicher, K., Cullen, J., Gookin, J., Seiler, G., Lunn, K., Mathews, K., & Correa, M. (2016). HP02 Association of gallbladder mucocele formation with occult hypothyroidism in dogs: A matched case-controlled study. Journal of Veterinary Internal Medicine. 40(4), 1407-1519. https://doi.org/10.1111/jvim.13952 Aicher, K. M., Cullen, J. M., Seiler, G. S., Lunn, K. F., Mathews, K. G., & Gookin, J. L. (2019). Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation. PLOS ONE, 14(2), e0212638. https://doi.org/10.1371/journal.pone.0212638 Gookin, J. L., Correa, M. T., Peters, A., Malueg, A., Mathews, K. G., Cullen, J., & Seiler, G. (2015). Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. Journal of Veterinary Internal Medicine, 29(6), 1464-1472. https://doi.org/10.1111/jvim.13649 Gookin, J. L., Mathews, K. G., Cullen, J., & Seiler, G. (2018). Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation. PLOS ONE, 13(1), e0191076. https://doi.org/10.1371/journal.pone.0191076 |
Grant Number: 02164-MOU Research Program Area: Ophthalmology |
Determining the Genetic Contribution to Boxer Corneal Ulcers Meurs, K. M., Montgomery, K., Friedenberg, S. G., Williams, B., & Gilger, B. C. (2021). A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs. BMC Veterinary Research, 17(1), 254. https://doi.org/10.1186/s12917-021-02955-1 |
Grant Number: 02321 Research Program Area: Oncology |
Clinical Trial of Procaspase-3 Activator (PAC-1) in Combination with Hydroxyurea for Treatment of Canine Meningioma Tonogai, E. J., Huang, S., Botham, R. C., Berry, M. R., Joslyn, S. K., Daniel, G. B., Chen, Z., Rao, J., Zhang, X., Basuli, F., Rossmeisl, J. H., Riggins, G. J., LeBlanc, A. K., Fan, T. M., & Hergenrother, P. J. (2021). Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients. Neuro-Oncology, noab161. https://doi.org/10.1093/neuonc/noab161 Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., … Fan, T. M. (2019). Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers. Frontiers in Oncology, 9 (96). https://doi.org/10.3389/fonc.2019.00096 |
Grant Number: 02590-A Research Program Area: Ophthalmology |
Histologic characterization of Golden Retriever Pigmentary Uveitis Townsend, W. M., Huey, J. A., McCool, E., King, A., & Diehl, K. A. (2020). Golden retriever pigmentary uveitis: Challenges of diagnosis and treatment. Veterinary Ophthalmology, 0, 1–11. https://doi.org/10.1111/vop.12796 |
Grant Number: 02235-A Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon on 9/11/01 Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
Grant Number: 02681-A Research Program Area: Immunology and Infectious Disease |
Analysis of Canine Herpesvirus Isolates Using Next-Generation Sequencing Lewin, A. C., Coghill, L. M., Mironovich, M., Liu, C.-C., Carter, R. T., & Ledbetter, E. C. (2020). Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1. Viruses, 12(12), 1421. https://doi.org/10.3390/v12121421 |
Grant Number: 00568-A Research Program Area: General Canine Health |
Surveillance of Chest Radiographs and Bloodwork in Dogs Deployed to the World Trade Center, Pentagon and Staten Island Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 |
Grant Number: 01488-A Research Program Area: Reproductive Conditions |
Health Implications of Spay and Neuter: Golden Retriever and Labrador Retriever Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2020). Assisting Decision-Making on Age of Neutering for 35 Breeds of Dogs: Associated Joint Disorders, Cancers, and Urinary Incontinence. Frontiers in Veterinary Science, 7. https://doi.org/10.3389/fvets.2020.00388 Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2014). Long-Term Health Effects of Neutering Dogs: Comparison of Labrador Retrievers with Golden Retrievers. PLoS ONE, 9(7), e102241. https://doi.org/10.1371/journal.pone.0102241 Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2016). Neutering of German Shepherd Dogs: associated joint disorders, cancers and urinary incontinence. Veterinary Medicine and Science, 2(3), 191–199. https://doi.org/10.1002/vms3.34 Torres de la Riva, G., Hart, B. L., Farver, T. B., Oberbauer, A. M., Messam, L. L. McV., Willits, N., & Hart, L. A. (2013). Neutering Dogs: Effects on Joint Disorders and Cancers in Golden Retrievers. PLoS ONE, 8(2), e55937. https://doi.org/10.1371/journal.pone.0055937 |
Grant Number: 01982 Research Program Area: Cardiology |
Personalized Medicine: The Intersection of Genotype and Drug Responsiveness in the Treatment of Canine Pulmonary Hypertension Visser, L. C., Wood, J. E., & Johnson, L. R. (2020). Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15826
Visser, L. C., Im, M. K., Johnson, L. R., & Stern, J. A. (2016). Diagnostic Value of Right Pulmonary Artery Distensibility Index in Dogs with Pulmonary Hypertension: Comparison with Doppler Echocardiographic Estimates of Pulmonary Arterial Pressure. Journal of Veterinary Internal Medicine, 30(2), 543–552. https://doi.org/10.1111/jvim.13911
Ueda, Y., Johnson, L. R., Ontiveros, E. S., Visser, L. C., Gunther-Harrington, C. T., & Stern, J. A. (2019). Effect of a phosphodiesterase-5A ( PDE5A ) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension. Scientific Reports, 9(1), 6899. https://doi.org/10.1038/s41598-019-43318-z
Johnson, L. R., & Stern, J. A. (2019). Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15679
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Grant Number: 02322 Research Program Area: General Canine Health |
Analysis of the Health, Behavioral, and Longevity Data Collected in the 9/11 Medical Surveillance Longitudinal Study Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Hare, E., Kelsey, K. M., Serpell, J. A., & Otto, C. M. (2018). Behavior Differences Between Search-and-Rescue and Pet Dogs. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00118 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Article: Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
Grant Number: 02340 Research Program Area: Ophthalmology |
Clinical and Genetic Background of Progressive Retinal Atrophy in Miniature Schnauzers Kaukonen, M., Quintero, I., Mukarram, A., Hytönen, M. K., Holopainen, S., Wickstrom, K., Kyostila, K., Arumilli, M., Jalomaki, S., Daub, C., Kere, J., Lohi, H., & The DoGA Consortium. (2020). A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PLOS Genetics, 16(3), e1008659. doi.org/10.1371/journal.pgen.1008659 |
Grant Number: 2242 Research Program Area: General Canine Health |
Understanding the Genetics of Adverse Drug Reactions in Sighthounds
Martinez SE, Pandey AV, Perez Jimenez TE, Zhu Z, Court MH (2024) Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization. PLoS ONE 19(2): e0297191. https://doi.org/10.1371/journal.pone.0297191https://doi.org/10.1371/journal.pone.0297191 Martinez, S. E., Pandey, A. V., & Court, M. H. (2019). Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs. The FASEB Journal, 33(1_supplement), 506.9-506.9. https://doi.org/10.1096/fasebj.2019.33.1_supplement.506.9
Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070 Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z |
Grant Number: 02461-A Research Program Area: Immunology and Infectious Disease |
Innate immune response to Leptospira in naturally exposed dogs Rajeev, S., Toka, F. N., & Shiokawa, K. (2020). Potential use of a canine whole blood culture system to evaluate the immune response to Leptospira. Comparative Immunology, Microbiology and Infectious Diseases, 101546. https://doi.org/10.1016/j.cimid.2020.101546 |
Grant Number: 1445 Research Program Area: Gastrointestinal Disease |
Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing Manchester, A. C., Dogan, B., Guo, Y., & Simpson, K. W. (2020). Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15995 Dogan, B., Zhang, S., Kalla, S. E., Dogan, E. I., Guo, C., Ang, C. R., & Simpson, K. W. (2020). Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs. Antibiotics, 9(9), 540. https://doi.org/10.3390/antibiotics9090540 Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E., Balkman, C., Baxter, T. L., … Boyko, A. R. (2016). Complex disease and phenotype mapping in the domestic dog. Nature Communications, 7(1). https://doi.org/10.1038/ncomms10460 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.