1421: Genomic Resources for the Control of Canine Pyoderma

Grant Status: Closed

Grant Amount: $42,466
Dr. Stephen A. Kania, PhD, University of Tennessee
January 1, 2011 - June 30, 2013
Sponsor(s): American Bouvier des Flandres Club - Bouvier Health Foundation, American Sealyham Terrier Club, Bichon Frise Club of America, Inc., Briard Club of America Health & Education Trust, Bulldog Club of America Charitable Health Fund, Inc., Forsyth Kennel Club, French Bulldog Club of America, Golden Retriever Foundation, Great Pyrenees Club of America, Labrador Retriever Club, National Beagle Club, National Beagle Performace Pack Association, Newfoundland Club of America Charitable Trust, Old English Sheepdog Club of America, PK St. John French Bulldog Fund, Poodle Club of America Foundation, Rhodesian Ridgeback Club of the United States, Samoyed Club of America Education & Research Foundation, The K9 College, Versatility in Poodles, Inc., Welsh Terrier Club of America, Inc., Westie Foundation of America, Inc.
Breed(s): -All Dogs
Research Program Area: Dermatology and Allergic Disease

Project Summary

The emergence of methicillin-resistant staphylococci has made the treatment of canine skin infections with Staphylococcus pseudintermedius a difficult challenge. In fact some of these bacteria are resistant to all available antibiotics. There are many unanswered questions regarding antibiotic resistance and the underlying causes of skin infections. In addition, new strategies are needed to prevent and/or treat infections from these organisms such as vaccines or bacteriophage therapy. The foundation of these approaches rests on identification of the major strains of the bacterial species. To attain this goal we developed a new method of genetic tying and hundreds of bacterial isolates were obtained from all regions of the United States. Each sample was studied with regard to spectrum of antibiotic resistance and genetic background and we have made significant progress toward identifying the entire genome of the major strains of the bacterium. Using the latest technology, genomes have been assembled from two isolates representing the major clonal populations of S.pseudintermedius. We have nearly completed assembling the genomes of three additional genomes and plan to assemble a total of seven genomes. This project has provided important new information by identifying all of the thousands of genes contained within two isolates representing the most frequently occurring type of the bacterium. This information is being used to determine the role of the gene products in infection, to identify new targets for vaccine development, and to better understand the spread of antibiotic resistance between bacteria.

Publication(s)

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