Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 1445 Research Program Area: Gastrointestinal Disease |
Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing Manchester, A. C., Dogan, B., Guo, Y., & Simpson, K. W. (2020). Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15995 Dogan, B., Zhang, S., Kalla, S. E., Dogan, E. I., Guo, C., Ang, C. R., & Simpson, K. W. (2020). Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs. Antibiotics, 9(9), 540. https://doi.org/10.3390/antibiotics9090540 Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E., Balkman, C., Baxter, T. L., … Boyko, A. R. (2016). Complex disease and phenotype mapping in the domestic dog. Nature Communications, 7(1). https://doi.org/10.1038/ncomms10460 |
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Grant Number: 01943-A Research Program Area: General Canine Health |
In Support of Our Working Dogs: Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon 2013-2014 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Hunt, M., Otto, C. M., Serpell, J. A., & Alvarez, J. (2012). Interactions between Handler Well-Being and Canine Health and Behavior in Search and Rescue Teams. Anthrozoös, 25(3), 323–335. https://doi.org/10.2752/175303712X13403555186253 Jones, K. E., Dashfield, K., Downend, A. B., & Otto, C. M. (2004). Search-and-rescue dogs: An overview for veterinarians. Journal of the American Veterinary Medical Association, 225(6), 854–860. https://doi.org/10.2460/javma.2004.225.854 <>Otto, C. M., Downend, A. B., Moore, G. E., Daggy, J. K., Ranivand, D. L., Reetz, J. A., & Fitzgerald, S. D. (2009). Medical surveillance of search dogs deployed to the World Trade Center and Pentagon: 2001-2006. Journal of Veterinary Behavior, 4(6), 241. https://doi.org/10.1016/j.jveb.2009.04.002 Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: Lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x |
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Grant Number: 02436 Research Program Area: Cardiology |
Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease Adin, D., Atkins, C., Londoño, L., & Nero, B. D. (2020). Correction of serum chloride concentration in dogs with congestive heart failure. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15998 Adin, D., Kurtz, K., Atkins, C., Papich, M. G., & Vaden, S. (2019). Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease. Journal of Veterinary Internal Medicine, 1–12. https://doi.org/10.1111/jvim.15662 |
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Grant Number: 02235-A Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon on 9/11/01 Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
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Grant Number: 02590-A Research Program Area: Ophthalmology |
Histologic characterization of Golden Retriever Pigmentary Uveitis Townsend, W. M., Huey, J. A., McCool, E., King, A., & Diehl, K. A. (2020). Golden retriever pigmentary uveitis: Challenges of diagnosis and treatment. Veterinary Ophthalmology, 0, 1–11. https://doi.org/10.1111/vop.12796 |
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Grant Number: 2287 Research Program Area: Tick-Borne Disease Initiative |
Enhanced Testing for the Diagnosis of Bartonellosis in Dogs Neupane, P., Hegarty, B. C., Marr, H. S., Maggi, R. G., Birkenheuer, A. J., & Breitschwerdt, E. B. (2018). Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15301 Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology.https://doi.org/10.1128/JCM.01335-19 |
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Grant Number: 02681-A Research Program Area: Immunology and Infectious Disease |
Analysis of Canine Herpesvirus Isolates Using Next-Generation Sequencing Lewin, A. C., Coghill, L. M., Mironovich, M., Liu, C.-C., Carter, R. T., & Ledbetter, E. C. (2020). Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1. Viruses, 12(12), 1421. https://doi.org/10.3390/v12121421 |
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Grant Number: 00568-A Research Program Area: General Canine Health |
Surveillance of Chest Radiographs and Bloodwork in Dogs Deployed to the World Trade Center, Pentagon and Staten Island Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 |
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Grant Number: 2667 Research Program Area: Oncology |
Cellular Genomics - Molecular Cytogenetic Investigation of Canine Soft Tissue Sarcomas Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991
Breen, M. (2008). Canine cytogenetics - from band to basepair. Cytogenetic and Genome Research, 120(1–2), 50–60. https://doi.org/10.1159/000118740
Fosmire, S. P., Dickerson, E. B., Scott, A. M., Bianco, S. R., Pettengill, M. J., Meylemans, H., … Modiano, J. F. (2004). Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Laboratory Investigation, 84(5), 562–572. https://doi.org/10.1038/labinvest.3700080
Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-201
Kennerly, E., Thomson, S., Olby, N., Breen, M., & Gibson, G. (2004). Comparison of regional gene expression differences in the brains of the domestic dog and human. Human Genomics, 1(6), 435. https://doi.org/10.1186/1479-7364-1-6-435
Modiano, J F, Breen, M., Valli, V. E. O., Wojcieszyn, J. W., & Cutter, G. R. (2007). Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin’s lymphoma. Leukemia, 21(1), 184–187. https://doi.org/10.1038/sj.leu.2404392
Modiano, Jaime F, Breen, M., Lana, S. E., Ehrhart, N., Fosmire, S. P., Thomas, R., … Bellgrau, D. (2006). Naturally occurring translational models for development of cancer gene therapy. Gene Therapy and Molecular Biology, 10, 31–40.
Philipp, U., Quignon, P., Scott, A., Rak, S., André, C., Breen, M., & Leeb, T. (2003). Assignment of the canine myosin Va gene (MYO5A) to chromosome 30q14 by fluorescence in situ hybridization and radiation hybrid mapping. Cytogenetic and Genome Research, 101(1), 92C-92C. https://doi.org/10.1159/000073681
Philipp, U., Scott, A., Quignon, P., André, C., Breen, M., & Leeb, T. (2003). Assignment of the RAB27A gene to canine chromosome 30q15.1 by fluorescence in situ hybridization and radiation hybrid mapping. Cytogenetic and Genome Research, 101(1), 92E. https://doi.org/10.1159/000073683
Rak, S. G., Drogemuller, C., Leeb, T., Quignon, P., Andre, C., & Scott, A. (2003). Chromosomal assignment of 20 candidate genes for canine congenital sensorineural deafness by FISH and RH mapping. Cytogenetic and Genome Research, 101(2), 130–135.
Tiret, L., Blot, S., Kessler, J.-L., Gaillot, H., Breen, M., & Panthier, J.-J. (2003). The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome2. Human Genetics, 113(4), 297–306. https://doi.org/10.1007/s00439-003-0984-7
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Grant Number: 01557 Research Program Area: Oncology |
Narrowing the Search for the Genetic Basis of Histiocytic Malignancies Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991 Kennedy, K., Thomas, R., Durrant, J., Jiang, T., Motsinger-Reif, A., & Breen, M. (2019). Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome Research. https://doi.org/10.1007/s10577-019-09606-0 Kennedy, K., Thomas, R., & Breen, M. (2016). Canine Histiocytic Malignancies—Challenges and Opportunities. Veterinary Sciences, 3(1), 2. https://doi.org/10.3390/vetsci3010002 |
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Grant Number: 01577 Research Program Area: Oncology |
Identifying the Genes Conferring Risk for Transitional Cell Carcinoma Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors. BMC Cancer, 20(251). https://doi.org/10.1186/s12885-020-06737-0 Decker, B., Parker, H. G., Dhawan, D., Kwon, E. M., Karlins, E., Davis, B. W., … Ostrander, E. A. (2015). Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Molecular Cancer Research, 13(6), 993–1002. https://doi.org/10.1158/1541-7786.MCR-14-0689
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Grant Number: 02633 Research Program Area: Immunology and Infectious Disease |
Validation and Diagnostic Performance of a Novel Monoclonal Antibody based Histoplasma Urine Immunoassay in Dogs with Histoplasmosis Clark, K., & Hanzlicek, A. S. (2020). Evaluation of a novel monoclonal antibody-based enzyme immunoassay for detection of Histoplasma antigen in urine of dogs. Journal of Veterinary Internal Medicine, 1–20. https://doi.org/10.1111/jvim.16006 |
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Grant Number: 02264-A Research Program Area: Reproductive Conditions |
Role of E. Coli Biofilm in Canine Pyometra Fiamengo, T. E., Runcan, E. E., Premanandan, C., Blawut, B., & Coutinho da Silva, M. A. (2020). Evaluation of biofilm production by Escherichia coli isolated from clinical cases of canine pyometra. Topics in Companion Animal Medicine, 100429. https://doi.org/10.1016/j.tcam.2020.100429 |
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Grant Number: 02643-A Research Program Area: Oncology |
Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity Henry, J. G., Shoemaker, G., Prieto, J. M., Hannon, M. B., & Wakshlag, J. J. (2020). The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis. Veterinary and Comparative Oncology, e12669, e12669. https://doi.org/10.1111/vco.12669 |
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Grant Number: 390 Research Program Area: General Canine Health |
Extended Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
