2078: Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs

Grant Status: Closed

Grant Amount: $120,872
Dr. William Brian Saunders, DVM, PhD, Texas A&M AgriLife Research
January 1, 2014 - December 31, 2016
Sponsor(s): American Belgian Tervuren Club, Inc., , English Setter Association of America, Inc., German Shorthaired Pointer Club of America, Inc., Great Pyrenees Club of America, Labrador Retriever Club, Inc., Mastiff Club of America Charitable Trust, Rottweiler Health Foundation, United States Australian Shepherd Association, United States Australian Shepherd Foundation
Breed(s): -All Dogs
Research Program Area: Musculoskeletal Conditions and Disease

Abstract

Osteochondrosis is a common and debilitating disease affecting large, athletic dogs. Osteochondrosis is caused by abnormal endochondral ossification, the process by which growth plate cartilage adjacent to joint surfaces transitions from cartilage to bone. The result is excessively thickened cartilage that partially or completely separates from surrounding bone. Cartilage separation exposes the joint to underlying bone and creates a large loose body, termed a joint mouse, within the joint. Surgical or medical treatment results vary widely based on the affected joint, size of the osteochondrosisdefect, and intended purpose for each dog. Treatment options for osteochondrosishave remained essentially unchanged for decades. Tissue engineering represents a promising treatment alternative for dogs suffering from OC. Dr. Saunders believes the key to successful tissue engineering involves generation of regenerative osteochondral plugs, or ROPs. ROPs are tri-layered cylindrical plugs composed of hydrogels seeded with adult mesenchymal stem cells (MSCs). Each ROP layer is composed of materials that closely mimic specific zones of the joint and adjacent bone. ROP layers are bioactive, directing encapsulated MSCs to differentiate into specific tissues to more efficiently restore normal joint anatomy. Dr. Saunders will optimize the materials used to generate ROP layers and will determine if MSCs from tissue lining the joint (synovium) or inner cavity of bones (bone marrow) more effectively reconstruct native cartilage, transitional tissue, or bone. This work represents an important advance in canine regenerative medicine and is highly applicable to dogs with osteochondrosisor other common joint ailments such as osteoarthritis.

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