Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02458-A Research Program Area: Immunology and Infectious Disease |
A Laboratory Test for Detecting Drug Resistance in Canine Heartworm Disease Jesudoss Chelladurai, J. R. J., Martin, K. A., Chinchilla-Vargas, K., Jimenez Castro, P. D., Kaplan, R. M., & Brewer, M. T. (2020). Laboratory assays reveal diverse phenotypes among microfilariae of Dirofilaria immitis isolates with known macrocyclic lactone susceptibility status. PLOS ONE, 15(8), e0237150. https://doi.org/10.1371/journal.pone.0237150 |
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Grant Number: 02139-A Research Program Area: Neurology |
Development of a Neuromusculoskeletal Computer Simulation Gait Model to Characterize Functional Recovery in Dogs with Intervertebral Disk Herniation Brown, N. P., Bertocci, G. E., States, G. J. R., Levine, G. J., Levine, J. M., & Howland, D. R. (2020). Development of a Canine Rigid Body Musculoskeletal Computer Model to Evaluate Gait. Frontiers in Bioengineering and Biotechnology, 8. https://doi.org/10.3389/fbioe.2020.00150 |
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Grant Number: 01985 Research Program Area: Neurology |
Defining Novel Drug Targets to Treat Chronic and Neuropathic Pain in the Dog Sophocleous, R. A., Miles, N. A., Ooi, L., & Sluyter, R. (2020). P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells. International Journal of Molecular Sciences, 21(22), 8572. https://doi.org/10.3390/ijms21228572 Sophocleous, R. A., Berg, T., Finol‐Urdaneta, R. K., Sluyter, V., Keshiya, S., Bell, L., Curtis, S. J., Curtis, B. L., Seavers, A., Bartlett, R., Dowton, M., Stokes, L., Ooi, L., & Sluyter, R. (2020). Pharmacological and genetic characterisation of the canine P2X4 receptor. British Journal of Pharmacology, 177(12), 2812–2829. https://doi.org/10.1111/bph.15009 Bartlett, R., Stokes, L., & Sluyter, R. (2014). The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease. Pharmacological Reviews, 66(3), 638–675. https://doi.org/10.1124/pr.113.008003 Faulks, M., Kuit, T. A., Sophocleous, R. A., Curtis, B. L., Curtis, S. J., Jurak, L. M., & Sluyter, R. (2016). P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes. World Journal of Hematology, 5(4), 88. https://doi.org/10.5315/wjh.v5.i4.88 Pupovac, A., & Sluyter, R. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cellular and Molecular Life Sciences, 73(22), 4159–4173. https://doi.org/10.1007/s00018-016-2274-2 Sluyter, R. (2015). P2X and P2Y receptor signaling in red blood cells. Frontiers in Molecular Biosciences, 2(60), 1–7. https://doi.org/10.3389/fmolb.2015.00060 Sophocleous, R. A., Sluyter, V., Curtis, B. L., Curtis, S. J., Jurak, L. M., Faulks, M., … Sluyter, R. (2019). Association of a P2RX7 gene missense variant with brachycephalic dog breeds. Animal Genetics. https://doi.org/10.1111/age.12884 |
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Grant Number: 01336A Research Program Area: Oncology |
Finding the Mutations that Increase Susceptibility to Transitional Cell Carcinoma in the Scottish Terrier, West Highland Terrier, and Shetland Sheepdog Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0
Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010). Man’s Best Friend Becomes Biology’s Best in Show: Genome Analyses in the Domestic Dog. Annual Review of Genetics, 44(1), 309–336. https://doi.org/10.1146/annurev-genet-102808-115200 Shearin, A. L., & Ostrander, E. A. (2010). Leading the way: canine models of genomics and disease. Disease Models & Mechanisms, 3(1–2), 27–34. https://doi.org/10.1242/dmm.004358 |
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Grant Number: 02386-A Research Program Area: Tick-Borne Disease Initiative |
Surveillance of Hepatozoon americanum In Populations of the Gulf Coast Tick Vector Parkins, N. D., Stokes, J. V., Gavron, N. A., Frankovich, A. N., & Varela-Stokes, A. S. (2020). Scarcity of Hepatozoon americanum in Gulf Coast tick vectors and potential for cultivating the protozoan. Veterinary Parasitology: Regional Studies and Reports, 21, 100421. https://doi.org/10.1016/j.vprsr.2020.100421 |
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Grant Number: 02050 Research Program Area: Immunology and Infectious Disease |
Defining the Genetic Susceptibility to Granulomatous Colitis, a Severe Form of Inflammatory Bowel Disease Dogan, B., Zhang, S., Kalla, S. E., Dogan, E. I., Guo, C., Ang, C. R., & Simpson, K. W. (2020). Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs. Antibiotics, 9(9), 540. https://doi.org/10.3390/antibiotics9090540 Manchester, A. C., Dogan, B., Guo, Y., & Simpson, K. W. (2020). Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15995 |
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Grant Number: 02805-E Research Program Area: General Canine Health |
Review of the Current State of Canine Genetic Testing - A Living Resource Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x |
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Grant Number: 2336 Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Fitzgerald, S. D., Rumbeiha, W. K., Braselton, W. E., Downend, A. B., & Otto, C. M. (2008). Pathology and Toxicology Findings for Search-and-Rescue Dogs Deployed to the September 11, 2001, Terrorist Attack Sites: Initial Five-Year Surveillance. Journal of Veterinary Diagnostic Investigation, 20(4), 477–484. https://doi.org/10.1177/104063870802000410
Hare, E., Kelsey, K. M., Serpell, J. A., & Otto, C. M. (2018). Behavior Differences Between Search-and-Rescue and Pet Dogs. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00118
Jones, K. E., Dashfield, K., Downend, A. B., & Otto, C. M. (2004). Search-and-rescue dogs: an overview for veterinarians. Journal of the American Veterinary Medical Association, 225(6), 854–860. https://doi.org/10.2460/javma.2004.225.854
Otto, C. M., Downend, A. B., Serpell, J. A., Ziemer, L. S., & Saunders, H. M. (2004). Medical and behavioral surveillance of dogs deployed to the World Trade Center and the Pentagon from October 2001 to June 2002. Journal of the American Veterinary Medical Association, 225(6), 861–867. https://doi.org/10.2460/javma.2004.225.861
Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x
Slensky, K. A., Drobatz, K. J., Downend, A. B., & Otto, C. M. (2004). Deployment morbidity among search-and-rescue dogs used after the September 11, 2001, terrorist attacks. Journal of the American Veterinary Medical Association, 225(6), 868–873. https://doi.org/10.2460/javma.2004.225.868
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Grant Number: 02348 Research Program Area: Blood Disorders |
Whole Blood Transcriptome Profiling of Dogs with Immune-Mediated Hemolytic Anemia (IMHA) Borchert, C., Herman, A., Roth, M., Brooks, A. C., & Friedenberg, S. G. (2020). RNA sequencing of whole blood in dogs with primary immune-mediated hemolytic anemia (IMHA) reveals novel insights into disease pathogenesis. PLOS ONE, 15(10), e0240975. https://doi.org/10.1371/journal.pone.0240975 |
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Grant Number: 02569-MOU Research Program Area: Ophthalmology |
Development of a Polygenic Risk Model for Pigmentary Uveitis in Golden Retrievers Townsend, W. M., Huey, J. A., McCool, E., King, A., & Diehl, K. A. (2020). Golden retriever pigmentary uveitis: Challenges of diagnosis and treatment. Veterinary Ophthalmology, 0, 1–11. https://doi.org/10.1111/vop.12796 Jost, H. E., Townsend, W. M., Moore, G. E., & Liang, S. (2020). Golden retriever pigmentary uveitis: Vision loss, risk factors for glaucoma, and effect of treatment on disease progression. Veterinary Ophthalmology. https://doi.org/10.1111/vop.12841 |
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Grant Number: 00887-A Research Program Area: General Canine Health |
Extended Surveillance of Chest Radiographs and Bloodwork in Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 |
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Grant Number: 02663 Research Program Area: Oncology |
Comparative Brain Tumor Consortium (CBTC) Meningioma Pathology Board Why Dogs Now Play a Big Role in Human Cancer Research. (n.d.). Retrieved July 23, 2019, from WIRED website: https://www.wired.com/story/why-dogs-now-play-a-big-role-in-human-cancer-research/ Amin, S. B., Anderson, K. J., Boudreau, C. E., Martinez-Ledesma, E., Kocakavuk, E., Johnson, K. C., Barthel, F. P., Varn, F. S., Kassab, C., Ling, X., Kim, H., Barter, M., Lau, C. C., Ngan, C. Y., Chapman, M., Koehler, J. W., Long, J. P., Miller, A. D., Miller, C. R., … Verhaak, R. G. W. (2020). Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. Cancer Cell , 37(2), 243-257.e7. https://doi.org/10.1016/j.ccell.2020.01.004 |
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Grant Number: 02637-A Research Program Area: Blood Disorders |
Reducing Misdiagnosis of Immune-Mediated Hemolytic Anemia Sun, P. L., & Jeffery, U. (2020). Effect of dilution of canine blood samples on the specificity of saline agglutination tests for immune-mediated hemolysis. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15945 |
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Grant Number: 2242 Research Program Area: General Canine Health |
Understanding the Genetics of Adverse Drug Reactions in Sighthounds
Martinez, S. E., Jimenez, T. E. P., & Court, M. H. (2024). Validation of a bupropion, dextromethorphan, and omeprazole cocktail for simultaneous phenotyping of cytochrome P450 2B11, 2D15, and 3A12 activities in dogs. American Journal of Veterinary Research https://doi.org/10.2460/ajvr.24.02.0049 Martinez SE, Pandey AV, Perez Jimenez TE, Zhu Z, Court MH (2024) Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization. PLoS ONE 19(2): e0297191. https://doi.org/10.1371/journal.pone.0297191https://doi.org/10.1371/journal.pone.0297191 Martinez, S. E., Pandey, A. V., & Court, M. H. (2019). Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs. The FASEB Journal, 33(1_supplement), 506.9-506.9. https://doi.org/10.1096/fasebj.2019.33.1_supplement.506.9
Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070 Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z |
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Grant Number: 02461-A Research Program Area: Immunology and Infectious Disease |
Innate immune response to Leptospira in naturally exposed dogs Rajeev, S., Toka, F. N., & Shiokawa, K. (2020). Potential use of a canine whole blood culture system to evaluate the immune response to Leptospira. Comparative Immunology, Microbiology and Infectious Diseases, 101546. https://doi.org/10.1016/j.cimid.2020.101546 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
