Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02264-A Research Program Area: Reproductive Conditions |
Role of E. Coli Biofilm in Canine Pyometra Fiamengo, T. E., Runcan, E. E., Premanandan, C., Blawut, B., & Coutinho da Silva, M. A. (2020). Evaluation of biofilm production by Escherichia coli isolated from clinical cases of canine pyometra. Topics in Companion Animal Medicine, 100429. https://doi.org/10.1016/j.tcam.2020.100429 |
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Grant Number: 02643-A Research Program Area: Oncology |
Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity Henry, J. G., Shoemaker, G., Prieto, J. M., Hannon, M. B., & Wakshlag, J. J. (2020). The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis. Veterinary and Comparative Oncology, e12669, e12669. https://doi.org/10.1111/vco.12669 |
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Grant Number: 390 Research Program Area: General Canine Health |
Extended Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 |
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Grant Number: 02590-A Research Program Area: Ophthalmology |
Histologic characterization of Golden Retriever Pigmentary Uveitis Townsend, W. M., Huey, J. A., McCool, E., King, A., & Diehl, K. A. (2020). Golden retriever pigmentary uveitis: Challenges of diagnosis and treatment. Veterinary Ophthalmology, 0, 1–11. https://doi.org/10.1111/vop.12796 |
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Grant Number: 2287 Research Program Area: Tick-Borne Disease Initiative |
Enhanced Testing for the Diagnosis of Bartonellosis in Dogs Neupane, P., Hegarty, B. C., Marr, H. S., Maggi, R. G., Birkenheuer, A. J., & Breitschwerdt, E. B. (2018). Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15301 Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology.https://doi.org/10.1128/JCM.01335-19 |
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Grant Number: 02681-A Research Program Area: Immunology and Infectious Disease |
Analysis of Canine Herpesvirus Isolates Using Next-Generation Sequencing Lewin, A. C., Coghill, L. M., Mironovich, M., Liu, C.-C., Carter, R. T., & Ledbetter, E. C. (2020). Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1. Viruses, 12(12), 1421. https://doi.org/10.3390/v12121421 |
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Grant Number: 00568-A Research Program Area: General Canine Health |
Surveillance of Chest Radiographs and Bloodwork in Dogs Deployed to the World Trade Center, Pentagon and Staten Island Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 |
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Grant Number: 02139-A Research Program Area: Neurology |
Development of a Neuromusculoskeletal Computer Simulation Gait Model to Characterize Functional Recovery in Dogs with Intervertebral Disk Herniation Brown, N. P., Bertocci, G. E., States, G. J. R., Levine, G. J., Levine, J. M., & Howland, D. R. (2020). Development of a Canine Rigid Body Musculoskeletal Computer Model to Evaluate Gait. Frontiers in Bioengineering and Biotechnology, 8. https://doi.org/10.3389/fbioe.2020.00150 |
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Grant Number: 2242 Research Program Area: General Canine Health |
Understanding the Genetics of Adverse Drug Reactions in Sighthounds
Martinez, S. E., Jimenez, T. E. P., & Court, M. H. (2024). Validation of a bupropion, dextromethorphan, and omeprazole cocktail for simultaneous phenotyping of cytochrome P450 2B11, 2D15, and 3A12 activities in dogs. American Journal of Veterinary Research https://doi.org/10.2460/ajvr.24.02.0049 Martinez SE, Pandey AV, Perez Jimenez TE, Zhu Z, Court MH (2024) Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization. PLoS ONE 19(2): e0297191. https://doi.org/10.1371/journal.pone.0297191https://doi.org/10.1371/journal.pone.0297191 Martinez, S. E., Pandey, A. V., & Court, M. H. (2019). Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs. The FASEB Journal, 33(1_supplement), 506.9-506.9. https://doi.org/10.1096/fasebj.2019.33.1_supplement.506.9
Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070 Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z |
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Grant Number: 02461-A Research Program Area: Immunology and Infectious Disease |
Innate immune response to Leptospira in naturally exposed dogs Rajeev, S., Toka, F. N., & Shiokawa, K. (2020). Potential use of a canine whole blood culture system to evaluate the immune response to Leptospira. Comparative Immunology, Microbiology and Infectious Diseases, 101546. https://doi.org/10.1016/j.cimid.2020.101546 |
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Grant Number: 1445 Research Program Area: Gastrointestinal Disease |
Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing Manchester, A. C., Dogan, B., Guo, Y., & Simpson, K. W. (2020). Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15995 Dogan, B., Zhang, S., Kalla, S. E., Dogan, E. I., Guo, C., Ang, C. R., & Simpson, K. W. (2020). Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs. Antibiotics, 9(9), 540. https://doi.org/10.3390/antibiotics9090540 Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E., Balkman, C., Baxter, T. L., … Boyko, A. R. (2016). Complex disease and phenotype mapping in the domestic dog. Nature Communications, 7(1). https://doi.org/10.1038/ncomms10460 |
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Grant Number: 01943-A Research Program Area: General Canine Health |
In Support of Our Working Dogs: Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon 2013-2014 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Hunt, M., Otto, C. M., Serpell, J. A., & Alvarez, J. (2012). Interactions between Handler Well-Being and Canine Health and Behavior in Search and Rescue Teams. Anthrozoös, 25(3), 323–335. https://doi.org/10.2752/175303712X13403555186253 Jones, K. E., Dashfield, K., Downend, A. B., & Otto, C. M. (2004). Search-and-rescue dogs: An overview for veterinarians. Journal of the American Veterinary Medical Association, 225(6), 854–860. https://doi.org/10.2460/javma.2004.225.854 <>Otto, C. M., Downend, A. B., Moore, G. E., Daggy, J. K., Ranivand, D. L., Reetz, J. A., & Fitzgerald, S. D. (2009). Medical surveillance of search dogs deployed to the World Trade Center and Pentagon: 2001-2006. Journal of Veterinary Behavior, 4(6), 241. https://doi.org/10.1016/j.jveb.2009.04.002 Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: Lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x |
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Grant Number: 02436 Research Program Area: Cardiology |
Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease Adin, D., Atkins, C., Londoño, L., & Nero, B. D. (2020). Correction of serum chloride concentration in dogs with congestive heart failure. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15998 Adin, D., Kurtz, K., Atkins, C., Papich, M. G., & Vaden, S. (2019). Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease. Journal of Veterinary Internal Medicine, 1–12. https://doi.org/10.1111/jvim.15662 |
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Grant Number: 2336 Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Fitzgerald, S. D., Rumbeiha, W. K., Braselton, W. E., Downend, A. B., & Otto, C. M. (2008). Pathology and Toxicology Findings for Search-and-Rescue Dogs Deployed to the September 11, 2001, Terrorist Attack Sites: Initial Five-Year Surveillance. Journal of Veterinary Diagnostic Investigation, 20(4), 477–484. https://doi.org/10.1177/104063870802000410
Hare, E., Kelsey, K. M., Serpell, J. A., & Otto, C. M. (2018). Behavior Differences Between Search-and-Rescue and Pet Dogs. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00118
Jones, K. E., Dashfield, K., Downend, A. B., & Otto, C. M. (2004). Search-and-rescue dogs: an overview for veterinarians. Journal of the American Veterinary Medical Association, 225(6), 854–860. https://doi.org/10.2460/javma.2004.225.854
Otto, C. M., Downend, A. B., Serpell, J. A., Ziemer, L. S., & Saunders, H. M. (2004). Medical and behavioral surveillance of dogs deployed to the World Trade Center and the Pentagon from October 2001 to June 2002. Journal of the American Veterinary Medical Association, 225(6), 861–867. https://doi.org/10.2460/javma.2004.225.861
Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x
Slensky, K. A., Drobatz, K. J., Downend, A. B., & Otto, C. M. (2004). Deployment morbidity among search-and-rescue dogs used after the September 11, 2001, terrorist attacks. Journal of the American Veterinary Medical Association, 225(6), 868–873. https://doi.org/10.2460/javma.2004.225.868
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Grant Number: 02348 Research Program Area: Blood Disorders |
Whole Blood Transcriptome Profiling of Dogs with Immune-Mediated Hemolytic Anemia (IMHA) Borchert, C., Herman, A., Roth, M., Brooks, A. C., & Friedenberg, S. G. (2020). RNA sequencing of whole blood in dogs with primary immune-mediated hemolytic anemia (IMHA) reveals novel insights into disease pathogenesis. PLOS ONE, 15(10), e0240975. https://doi.org/10.1371/journal.pone.0240975 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
