Peer-Reviewed Publications Resulting from CHF-funded Grants

Grant Number: 02575-MOU

Research Program Area: Neurology

Norton, E. M., Minor, K. M., Taylor, S. M., McCue, M. E., & Mickelson, J. R. (2021). Heritability and Genomic Architecture of Episodic Exercise-Induced Collapse in Border Collies. Genes, 12(12), 1927. https://doi.org/10.3390/genes12121927

Grant Number: 01236-A

Research Program Area: Endocrinology

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2021). Whole Genome Sequencing Reveals Multiple Linked Genetic Variants on Canine Chromosome 12 Associated with Risk for Symmetrical Lupoid Onychodystrophy (SLO) in the Bearded Collie. Genes, 12(8), 1265. https://doi.org/10.3390/genes12081265

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., Famula, T. R., & Oberbauer, A. M. (2020). Genetic characterization of Addison’s disease in Bearded Collies. BMC Genomics, 21(1), 833. https://doi.org/10.1186/s12864-020-07243-0

Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the Bearded Collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635

Rincon, G., Tengvall, K., Belanger, J. M., Lagoutte,L., Medrano, J. F., André, C., … Oberbauer, A. M. (2011). Comparison of buccaland blood-derived canine DNA, either native or whole genome amplified, forarray-based genome-wide association studies. BMC Research Notes, 4(1),226. https://doi.org/10.1186/1756-0500-4-226

Grant Number: 01609

Research Program Area: Gastrointestinal Disease

White, R., Atherly, T., Guard, B., Rossi, G., Wang, C., Mosher, C., Webb, C., Hill, S., Ackermann, M., Sciabarra, P., Allenspach, K., Suchodolski, J., & Jergens, A. E. (2017). Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease. Gut Microbes, 8(5), 451–466. https://doi.org/10.1080/19490976.2017.1334754

Pilla, R., Guard, B.C., Blake, A.B., Ackermann, M., Webb, C.; Hill, S., Lidbury, J.A., Steiner, J.M., Jergens, A.E., Suchodolski, J.S. (2021). Long-Term Recovery of the Fecal Microbiome and Metabolome of Dogs with Steroid-Responsive Enteropathy. Animals. 11 (6), 2498. https://doi.org/10.3390/ani11092498

Minamoto, Y., Otoni, C. C., Steelman, S. M., Büyükleblebici, O., Steiner, J. M., Jergens, A. E., & Suchodolski, J. S. (2015). Alteration of the fecal microbiota and serum metabolite profiles in dogs with idiopathic inflammatory bowel disease. Gut Microbes, 6(1), 33–47. https://doi.org/10.1080/19490976.2014.997612

Otoni, C. C., Heilmann, R. M., García‐Sancho, M., Sainz, A., Ackermann, M. R., Suchodolski, J. S., … Jergens, A. E. (2018). Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease. Journal of Veterinary Internal Medicine, 32(3), 999–1008. https://doi.org/10.1111/jvim.15123

Rossi, G., Pengo, G., Caldin, M., Palumbo Piccionello, A., Steiner, J. M., Cohen, N. D., … Suchodolski, J. S. (2014). Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease. PLoS ONE, 9(4), e94699. https://doi.org/10.1371/journal.pone.0094699

Grant Number: 02520-MOU

Research Program Area: Cardiology

Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02417-A

Research Program Area: Endocrinology

Nivy, R., Kuzi, S., Yochai, A., Aroch, I., & Bruchim, Y. (2021). Evaluation of serum histone concentrations and their associations with hemostasis, markers of inflammation, and outcome in dogs with naturally occurring acute pancreatitis. American Journal of Veterinary Research, 82(9), 701–711. https://doi.org/10.2460/ajvr.82.9.701

Grant Number: 02488

Research Program Area: Endocrinology

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2021). Whole Genome Sequencing Reveals Multiple Linked Genetic Variants on Canine Chromosome 12 Associated with Risk for Symmetrical Lupoid Onychodystrophy (SLO) in the Bearded Collie. Genes, 12(8), 1265. https://doi.org/10.3390/genes12081265

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., Famula, T. R., & Oberbauer, A. M. (2020). Genetic characterization of Addison’s disease in Bearded Collies. BMC Genomics, 21(1), 833. https://doi.org/10.1186/s12864-020-07243-0

Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635

Grant Number: 02162-MOU

Research Program Area: Neurology

Sparks, C. R., Woelfel, C., Robertson, I., & Olby, N. J. (2021). Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16023

Sparks, C. R., Cerda‐Gonzalez, S., Griffith, E. H., Lascelles, B. D. X., & Olby, N. J. (2018). Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia. Journal of Veterinary Internal Medicine, 32(1), 331–339. https://doi.org/10.1111/jvim.14856

Sparks, C. R., Robertson, I., & Olby, N. J. (2019). Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 1–9. https://doi.org/10.1111/jvim.15437

Sparks, Courtney R., Gorney, A., Williams, K., Griffith, E. H., Cerda‐Gonzalez, S., Lascelles, B. D. X., & Olby, N. J. (2018). Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia. Journal of Veterinary Internal Medicine, 32(6), 2021–2028. https://doi.org/10.1111/jvim.15297

Grant Number: 02446

Research Program Area: Oncology

Hédan, B., Cadieu, É., Rimbault, M., Vaysse, A., Citres, C. D. de, Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., Derrien, T., & André, C. (2021). Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLOS Genetics, 17(4), e1009395. https://doi.org/10.1371/journal.pgen.1009395

Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y

Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991

Grant Number: 02502

Research Program Area: Oncology - Lymphoma

Wang, G., Wu, M., Durham, A. C., Mason, N. J., & Roth, D. B. (2021). Canine Oncopanel: A capture-based, NGS platform for evaluating the mutational landscape and detecting putative driver mutations in canine cancers. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12746

Grant Number: 02651

Research Program Area: Dermatology and Allergic Disease

Franco, J., Rajwa, B., Gomes, P., & HogenEsch, H. (2021). Local and Systemic Changes in Lipid Profile as Potential Biomarkers for Canine Atopic Dermatitis. Metabolites, 11(10), 670. https://doi.org/10.3390/metabo11100670

Grant Number: 02318

Research Program Area: Oncology - Lymphoma

Smith, N., Luethcke, K. R., Craun, K., & Trepanier, L. (2021). Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12771

Craun, K., Ekena, J., Sacco, J., Jiang, T., Motsinger‐Reif, A., & Trepanier, L. A. (2020). Genetic and environmental risk for lymphoma in boxer dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15849

Grant Number: 02782

Research Program Area: Oncology - Osteosarcoma

Momen, M., Kohler, N. L., Binversie, E. E., Dentino, M., & Sample, S. J. (2021). Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information. Canine Medicine and Genetics, 8(1), 9. https://doi.org/10.1186/s40575-021-00109-y

Grant Number: 2292

Research Program Area: Tick-Borne Disease Initiative

Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163

Vasconcelos, E. J. R., Roy, C., Geiger, J. A., Oney, K. M., Koo, M., Ren, S., Oakley, B. B., & Diniz, P. P. V. P. (2021). Data analysis workflow for the detection of canine vector-borne pathogens using 16 S rRNA Next-Generation Sequencing. BMC Veterinary Research, 17(1), 262. https://doi.org/10.1186/s12917-021-02969-9

Grant Number: 02165-MOU

Research Program Area: Neurology

Lewis, M. J., Shomper, J. L., Williamson, B. G., Vansteenkiste, D. P., Bibi, K. F., Lim, S. H. Y., Kowal, J. B., & Coates, J. R. (2021). Brain diffusion tensor imaging in dogs with degenerative myelopathy. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16248

Toedebusch, C. M., Garcia, V. B., Snyder, J. C., Jones, M. R., Schulz, D. J., Johnson, G. C., Villalón, E., Coates, J. R., & Garcia, M. L. (2019). Lumbar spinal cord microglia exhibited increased activation in aging dogs compared with young adult dogs. GeroScience. https://doi.org/10.1007/s11357-019-00133-8

Toedebusch, C. M., Bachrach, M. D., Garcia, V. B., Johnson, G. C., Katz, M. L., Shaw, G., … Garcia, M. L. (2017). Cerebrospinal Fluid Levels of Phosphorylated Neurofilament Heavy as a Diagnostic Marker of Canine Degenerative Myelopathy. Journal of Veterinary Internal Medicine, 31(2), 513–520. https://doi.org/10.1111/jvim.14659

Toedebusch, Christine M., Snyder, J. C., Jones, M. R., Garcia, V. B., Johnson, G. C., Villalón, E. L., … Garcia, M. L. (2018). Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis. Molecular and Cellular Neuroscience, 88, 148–157. https://doi.org/10.1016/j.mcn.2018.01.009

Grant Number: 02521-MOU

Research Program Area: Cardiology

Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052