02637-A: Reducing Misdiagnosis of Immune-Mediated Hemolytic Anemia

Grant Status: Open

Grant Amount: $5,995
Unity Jeffery, VetMB, PhD; Texas A&M University
February 1, 2019 - July 31, 2020


Breed(s): Wirehaired Vizsla, Bichon Frise, Maltese, English Springer Spaniel, Shih Tzu, Miniature Schnauzer, Miniature Pinscher, Finnish Spitz, Doberman Pinscher, Vizsla
Research Program Area: Blood Disorders
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Immune-mediated hemolytic anemia (IMHA) is a common life-threatening disease requiring intensive and expensive therapy. Veterinarians often diagnose IMHA using a saline agglutination test. This test aims to distinguish red cell aggregates induced by antibodies from non-immune-mediated red cell interactions. However, this test can produce up to 20% false positives, thus requiring an improved test.  One reason for the high false positive rate may be the test’s use of a 1:1 ratio of saline to blood, which may not be sufficient to break apart non-immune-mediated red cell interactions. This study will determine if increasing the ratio of saline to blood will reduce false positive results. The results could improve the diagnostic test and prevent misdiagnosis of IMHA and unnecessary immunosuppressive therapy. 


None at this time.

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