1985: Defining Novel Drug Targets to Treat Chronic and Neuropathic Pain in the Dog

Grant Status: Open

Grant Amount: $69,128
Dr. Ronald Sluyter, Ph.D., University of Wollongong
January 1, 2014 - December 31, 2015
Breed(s): -All Dogs
Research Program Area: Canine Athlete Initiative

Abstract

Through previous funding by the AKC Canine Health Foundation, Dr. Ronald Sluyter discovered a novel canine protein named the P2X Receptor. This receptor is responsible for movement of positively charged ions into cells and has been implicated in a wide range of cellular function in humans. Due to its ubiquitous expression and broad-based function, the P2X receptor is thought to play a decisive role in multiple diseases including chronic neuropathic and inflammatory pain, dry eye, irritable bowel syndrome, interstitial cystitis, dysfunctional urinary bladder, and cancer. In this grant Dr. Sluyter will focus on the role of the P2X receptor in pain in the dog. Chronic or long-lasting pain is a major health problem and welfare issue in dogs. Improved understanding of the mechanisms that define chronic pain will greatly aid in the development of new approaches and drugs to alleviate or treat chronic pain in dogs.

Publication(s)

Pupovac, A., & Sluyter, R. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cellular and Molecular Life Sciences, 73(22), 4159–4173. http://doi.org/10.1007/s00018-016-2274-2

Sluyter, R. (2015). P2X and P2Y receptor signaling in red blood cells. Frontiers in Molecular Biosciences.

Spildrejorde, M., Bartlett, R., Stokes, L., Jalilian, I., Peranec, M., Sluyter, V., … Sluyter, R. (2014). R270C polymorphism leads to loss of function of the canine P2X7 receptor. Physiological Genomics, 46(14), 512 LP-522. Retrieved from http://physiolgenomics.physiology.org/content/46/14/512.abstract

Bartlett, R., Stokes, L., & Sluyter, R. (2014). The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease. Pharmacological Reviews, 66(3), 638 LP-675. Retrieved from http://pharmrev.aspetjournals.org/content/66/3/638.abstract

Sluyter, R., Stokes, L. (2014). Polymorphic variants of the P2X7 receptor in the domestic dog. Jacobs Journal of Veterinary Science and Research, 7–9.

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