1985: Defining Novel Drug Targets to Treat Chronic and Neuropathic Pain in the Dog
Grant Status: Closed
Chronic or long-lasting pain is a major health problem and welfare issue in dogs. Chronic pain results from disease, injury or aging. Evidence from humans and rodents strongly implicates an important role for a group of molecules (termed P2X receptors) on white blood cells (within the bone joints, spinal cord and other body parts) in chronic pain. The roles of P2X receptors in dogs however remain poorly understood. Therefore, the proposed project aims to determine the roles of these receptors and how they contribute to chronic pain in dogs. Improved understanding of the factors that contribute to chronic pain will greatly aid in the development of new approaches and drugs to alleviate or treat chronic pain in dogs. We have determined that dogs express P2X4 receptors and that the gene coding this receptor is highly conserved between dogs, suggesting it may be a potential drug target to treat chronic pain in these animals.
Pupovac, A., & Sluyter, R. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cellular and Molecular Life Sciences, 73(22), 4159–4173. http://doi.org/10.1007/s00018-016-2274-2
Sluyter, R. (2015). P2X and P2Y receptor signaling in red blood cells. Frontiers in Molecular Biosciences.
Spildrejorde, M., Bartlett, R., Stokes, L., Jalilian, I., Peranec, M., Sluyter, V., … Sluyter, R. (2014). R270C polymorphism leads to loss of function of the canine P2X7 receptor. Physiological Genomics, 46(14), 512 LP-522. Retrieved from http://physiolgenomics.physiology.org/content/46/14/512.abstract
Bartlett, R., Stokes, L., & Sluyter, R. (2014). The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease. Pharmacological Reviews, 66(3), 638 LP-675. Retrieved from http://pharmrev.aspetjournals.org/content/66/3/638.abstract
Sluyter, R., Stokes, L. (2014). Polymorphic variants of the P2X7 receptor in the domestic dog. Jacobs Journal of Veterinary Science and Research, 7–9.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.