2242: Understanding the Genetics of Adverse Drug Reactions in Sighthounds

Grant Status: Open

Grant Amount: $150,000
Dr. Michael H. Court, PhD, Washington State University
February 1, 2016 - January 31, 2018
Breed(s): Greyhound, -All Dogs
Research Program Area: All

Abstract

Life-threatening unanticipated reactions to drugs with a narrow margin of safety (such as those used for anesthesia and to treat cancer) are a common concern for dog owners and veterinarians. However, research conducted at Washington State University has enabled development of a simple cheek swab test (the MDR1 gene test) that is now being used by veterinarians to identify dogs that should either avoid or have reduced doses of certain drugs used to treat cancer and parasite infections. Using a similar strategy the investigators have been conducting research to identify the cause of extremely slow recovery from anesthesia (up to several days) in a high proportion of greyhounds, and also in other sighthound breed dogs (such as Scottish deerhound, Borzoi, Whippets, etc.). The investigators have recently discovered a mutation in a gene that is known to be essential for metabolism (breaking down) many commonly used anesthetic drugs (such as propofol), as well as many other drugs used in dogs. Interestingly in addition to sighthound breeds, this gene mutation is also found in some other breeds such as Border Collies. The purpose of this research project is to prove that this mutation can cause decreased drug metabolism, while also determining which drugs and which dog breeds are likely to be most impacted. The ultimate goal of this study is to develop a genetic test that could be used by veterinarians to guide the safe use of these drugs in dogs with the gene mutation.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software