00859-A: Canine Immune-Mediated Hemolytic Anemia

Grant Status: Closed

Grant Amount: $12,960
Dr. Lorna J. Kennedy, PhD, University of Manchester
January 1, 2007 - December 31, 2008
Sponsor(s): American Cavalier King Charles Spaniel Club Charitable Trust
Breed(s): -All Dogs
Research Program Area: Prevention

Project Summary

We have previously identified a set of genes associated with Immune Mediated Haemolytic Anaemia (IMHA) in a region of the genome that is rich in immune genes. We have now performed a whole genome scan comparing 35 Cocker and Springer Spaniels having IMHA with 49 unaffected control dogs, which has revealed 91 SNPs that are significantly associated with IMHA, and are spread over 33 different canine chromosomes. Eight of these SNP associations are highly significant and give us great hope that we will be able to identify other genes/loci associated with this disease. If we can identify such genes, it may be possible to start selective breeding to reduce the risk of Cocker and Springer Spaniels developing IMHA.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software