Cardiology Grants
The Cardiology Research Program Area is designed to support integrated basic and clinical research to study normal and abnormal cardiovascular development. This program supports research in the general areas of:
- Heart Development
- Structural Disease
- Arrhythmias
- Diagnostics
- Therapeutics
- Surgery
- Enabling Technologies in research discovery
- Enabling Technologies in drug design and development
Active Grants:
| 03121 | Optimizing HITI CRISPR/Cas9 Gene Editing for Treating Defective Pyruvate Dehydrogenase Kinase 4 in Doberman Pinschers |
| 03101-A | Enhancing Autophagy to Control Canine Myxomatous Mitral Valve Disease |
| 03031 | Tolerability and Clinical Efficacy of Acetazolamide for Treatment of Hypochloremia in Canine Congestive Heart Failure |
| 02986 | Catechol O-Methyltransferase as a Molecular Drug Target in Heartworm |
| 02955 | Towards Precision Medicine for Canine Cardiac Disease: A Genomic and Machine-Learning Approach to Prediction of Risk and Outcomes in Canine Myxomatous Mitral Valve Disease |
| 02623 | Circulating Cortisol Concentrations in Canine Congestive Heart Failure |
| 02649 | Three-dimensional Echocardiographic Determinants of the Age of Onset of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels |
| 02661 | Investigation into Diet-Associated Dilated Cardiomyopathy in Dogs |
| 1760-T | Use of Gene Therapy to Treat Dilated Cardiomyopathy |
Previously Awarded Grants:
| 02632 | Canine Chagas Disease: Characterizing Cardiac Disease and Developing Screening Recommendations for Asymptomatic Dogs Seropositive for Trypanosoma cruzi |
| 02808-MOU | Identification of a Second Genetic Risk Allele(s) Associated with the Development of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog |
| 02550 | The Role of Bartonella spp. Exposure and Cardiac Genetic Variation on the Clinical Expression of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog |
| 02531 | Identification of Genetic Risk Allele(s) Associated with the Development of Tricuspid Valve Dysplasia in the Labrador Retriever |
| 02424 | Identification of Genetic Variants Associated with Pulmonary Valve Stenosis in Bulldogs through Whole-Genome Sequencing |
| 02388-MOU | Genetic Markers for Familial Subvalvular Aortic Stenosis in Newfoundlands |
| 02389-MOU | Characterization of Ventricular Arrhythmias in Rhodesian Ridgebacks |
| 02327-MOU | Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Bullmastiffs |
| 02520-MOU | Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Rottweilers |
| 02521-MOU | Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Golden Retrievers |
| 02368 | Identification of Mitral Valve Disease DNA variants in Miniature Schnauzers |
| 02631 | Genetic and Metabolic Determinants of Dilated Cardiomyopathy and their Relationship to Cardiac Arrhythmia in Doberman Pinschers |
| 02436 | Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease |
| 2046 | Using a Novel Combination of Drugs to Treat Arrhythmia and Heart Failure in Dogs |
| 02163 | Is Hypothyroidism a Contributor to Progression of Arrhythmogenic Right Ventricular Cardiomyopathy? |
| 02160 | Identification of Genetic Variants Associated with Myxomatous Mitral Valve Degeneration in the Whippet Dog through Whole-Genome Sequencing |
| 01982 | Personalized Medicine: The Intersection of Genotype and Drug Responsiveness in the Treatment of Canine Pulmonary Hypertension |
| 02227-MOU | Identification of Genetic Markers of Pulmonic Stenosis in Bulldogs |
| 02086-MOU | Defining the Genetic Basis of Myxomatous Mitral Valve Disease |
| 02147 | Use of MicroRNA Profiles in the Serum of Dogs for Early Diagnosis of Mitral Valve Disease and Dilated Cardiomyopathy |
| 02101 | Whole Genome Sequencing for Great Dane Dilated Cardiomyopathy |
| 01898-A | Enhancing Diagnosis and Treatment of Cardiomyopathy through Identification of Biological Markers of Disease |
| 01994 | Early and Accurate Prediction of Mitral Valve Disease Development |
| 01849 | Filling the Gaps in the Canine Genome |
| 01753 | Identification of Genetic Factors That Alter the Severity of Cardiomyopathy |
The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
